| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Harry Potter and the Deathly Hallows: Part 2 | - | - | - | $8,229,311 | 427 | $8,229,311 | Jul 29 | Warner Bros. | false |
| 2 | Transformers: Dark of the Moon | - | - | - | $6,880,457 | 306 | $6,880,457 | Aug 5 | United International Pictures | false |
| 3 | Mission: Impossible - Ghost Protocol | - | - | - | $4,455,670 | 208 | $6,142,288 | Dec 16 | United International Pictures | false |
| 4 | Kung Fu Panda 2 | - | - | - | $4,419,909 | 216 | $5,568,530 | Aug 16 | United International Pictures | false |
| 5 | Fast Five | - | - | - | $3,167,381 | 157 | $3,167,381 | Aug 12 | United International Pictures | false |
| 6 | Final Destination 5 | - | - | - | $2,511,970 | 132 | $2,814,779 | Sep 21 | Warner Bros. | false |
| 7 | Johnny English Reborn | - | - | - | $2,258,381 | 115 | $2,458,666 | Oct 26 | United International Pictures | false |
| 8 | Sherlock Holmes: A Game of Shadows | - | - | - | $2,166,542 | 142 | $3,432,887 | Dec 23 | Warner Bros. | false |
| 9 | Real Steel | - | - | - | $2,154,893 | 104 | $2,154,893 | Oct 28 | Walt Disney Pictures | false |
| 10 | Captain America: The First Avenger | - | - | - | $2,046,208 | 190 | $2,046,208 | Sep 9 | United International Pictures | false |
| 11 | The Adventures of Tintin | - | - | - | $1,952,330 | 120 | $1,981,881 | Nov 11 | Paramount Pictures International | false |
| 12 | The Tourist | - | - | - | $1,679,299 | 60 | $2,480,033 | Dec 29 | Sony Pictures Releasing | false |
| 13 | The Green Hornet | - | - | - | $1,452,702 | 80 | $1,513,920 | Feb 2 | Sony Pictures Releasing | false |
| 14 | Pirates of the Caribbean: On Stranger Tides | - | - | - | $1,195,898 | 102 | $1,309,600 | Sep 28 | Walt Disney Pictures | false |
| 15 | The Smurfs | - | - | - | $1,172,893 | 102 | $1,172,893 | Oct 7 | Sony Pictures Releasing | false |
| 16 | Puss in Boots | - | - | - | $993,944 | 81 | $993,944 | Nov 25 | United International Pictures | false |
| 17 | No Strings Attached | - | - | - | $897,762 | 33 | $957,560 | Feb 9 | United International Pictures | false |
| 18 | Faster | - | - | - | $869,180 | 40 | $902,981 | Jan 12 | Sony Pictures Releasing | false |
| 19 | Cars 2 | - | - | - | $620,905 | 82 | $670,199 | Oct 12 | Walt Disney Pictures | false |
| 20 | Happy Feet Two | - | - | - | $575,708 | 71 | $582,401 | Dec 9 | Warner Bros. | false |
| 21 | The Hangover Part II | - | - | - | $567,408 | 60 | $567,408 | Sep 16 | Warner Bros. | false |
| 22 | Little Fockers | - | - | - | $459,957 | 30 | $530,811 | Jan 5 | United International Pictures | false |
| 23 | Green Lantern | - | - | - | $451,022 | 78 | $451,022 | Oct 5 | Warner Bros. | false |
| 24 | Yogi Bear | - | - | - | $396,416 | 60 | $448,468 | Jan 19 | Warner Bros. | false |
| 25 | Burlesque | - | - | - | $300,665 | 30 | $312,480 | Jan 21 | Sony Pictures Releasing | false |
| 26 | Thor | - | - | - | $258,552 | 38 | $273,076 | Nov 3 | United International Pictures | false |
| 27 | Arthur Christmas | - | - | - | $246,263 | 71 | $246,263 | Dec 2 | Sony Pictures Releasing | false |
| 28 | Tron: Legacy | - | - | - | $228,079 | 110 | $2,467,545 | Dec 17 | Walt Disney Pictures | false |
| 29 | Super 8 | - | - | - | $216,826 | 50 | $286,789 | Oct 19 | United International Pictures | false |
| 30 | Contagion | - | - | - | $192,736 | 55 | $233,916 | Nov 16 | Warner Bros. | false |
| 31 | Jack and Jill | - | - | - | $161,772 | 37 | $450,648 | Dec 28 | Sony Pictures Releasing | false |
| 32 | Paranormal Activity 2 | - | - | - | $106,302 | 18 | $415,949 | Dec 3 | United International Pictures | false |
| 33 | Devil | - | - | - | $102,842 | 24 | $303,702 | Dec 15 | United International Pictures | false |
| 34 | Due Date | - | - | - | $59,414 | 30 | $368,517 | Dec 10 | Warner Bros. | false |
| 35 | Eat Pray Love | - | - | - | $53,569 | 40 | $1,530,403 | Oct 13 | Sony Pictures Releasing | false |
| 36 | Tangled | - | - | - | $50,865 | 70 | $1,894,079 | Dec 1 | Walt Disney Pictures | false |
| 37 | Cop Out | - | - | - | $50,328 | 26 | $318,420 | Apr 21 | Warner Bros. | false |
| 38 | Life as We Know It | - | - | - | $49,885 | 29 | $330,729 | Oct 22 | Warner Bros. | false |
| 39 | The Social Network | - | - | - | $27,252 | 30 | $366,544 | Nov 3 | Sony Pictures Releasing | false |
| 40 | Grown Ups | - | - | - | $22,054 | 15 | $488,409 | Aug 25 | Sony Pictures Releasing | false |
| 41 | The Book of Eli | - | - | - | $20,390 | 20 | $630,714 | Apr 14 | Sony Pictures Releasing | false |
| 42 | The Other Guys | - | - | - | $18,431 | 30 | $369,620 | Oct 6 | Sony Pictures Releasing | false |
| 43 | The Bounty Hunter | - | - | - | $16,589 | 20 | $242,605 | May 5 | Sony Pictures Releasing | false |
| 44 | You Again | - | - | - | $15,731 | 25 | $173,656 | Nov 10 | Walt Disney Pictures | false |
| 45 | Going the Distance | - | - | - | $12,875 | 18 | $97,943 | Oct 8 | Warner Bros. | false |
| 46 | Legion | - | - | - | $11,561 | 35 | $723,331 | Jan 27 | Sony Pictures Releasing | false |
| 47 | Harry Potter and the Deathly Hallows: Part 1 | - | - | - | $9,296 | 115 | $6,149,448 | Nov 19 | Warner Bros. | false |
| 48 | The Back-up Plan | - | - | - | $8,089 | 16 | $119,377 | Aug 11 | Sony Pictures Releasing | false |
| 49 | Underworld: Rise of the Lycans | - | - | - | $7,773 | 7 | $672,678 | Feb 4 | Sony Pictures Releasing | false |
| 50 | G-Force | - | - | - | $7,155 | 33 | $1,380,947 | Sep 16 | Walt Disney Pictures | false |
| 51 | Takers 2010 Re-release | - | - | - | $5,284 | 50 | $758,427 | Oct 27 | Sony Pictures Releasing | false |
| 52 | The Taking of Pelham 123 | - | - | - | $2,703 | 25 | $505,763 | Aug 12 | Sony Pictures Releasing | false |
| 53 | Green Zone | - | - | - | $1,859 | 44 | $1,032,116 | Mar 12 | United International Pictures | false |
| 54 | Shutter Island | - | - | - | $1,181 | 34 | $772,735 | Mar 3 | United International Pictures | false |
| 55 | The Losers | - | - | - | $1,118 | 25 | $170,810 | May 28 | Warner Bros. | false |
| 56 | Zombieland | - | - | - | $845 | 30 | $231,555 | Dec 9 | Sony Pictures Releasing | false |
| 57 | Unstoppable | - | - | - | $778 | 1 | $1,380,127 | Nov 24 | 20th Century Fox International | false |
| 58 | Inception | - | - | - | $512 | 70 | $2,439,468 | Jul 16 | Warner Bros. | false |
| 59 | Date Night | - | - | - | $102 | 25 | $394,137 | Apr 21 | 20th Century Fox International | false |
