| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Harry Potter and the Deathly Hallows: Part 2 | - | - | - | $6,487,988 | 173 | $6,487,988 | Jul 14 | Warner Bros. | false |
| 2 | Cars 2 | - | - | - | $5,399,990 | 133 | $5,424,295 | Jul 7 | Walt Disney Pictures | false |
| 3 | Pirates of the Caribbean: On Stranger Tides | - | - | - | $5,226,363 | 136 | $5,234,148 | May 19 | Walt Disney Pictures | false |
| 4 | Kung Fu Panda 2 | - | - | - | $4,651,631 | 134 | $4,682,918 | Jun 9 | United International Pictures | false |
| 5 | Transformers: Dark of the Moon | - | - | - | $4,463,201 | 152 | $4,512,095 | Jun 30 | United International Pictures | false |
| 6 | The Smurfs | - | - | - | $4,260,769 | 114 | $4,260,769 | Aug 4 | Sony Pictures Releasing | false |
| 7 | Fast Five | - | - | - | $2,097,536 | 61 | $2,097,536 | May 5 | United International Pictures | false |
| 8 | Captain America: The First Avenger | - | - | - | $1,619,307 | 98 | $1,619,307 | Jul 28 | United International Pictures | false |
| 9 | Tangled | - | - | - | $1,438,871 | 82 | $4,380,606 | Dec 30 | Walt Disney Pictures | false |
| 10 | The Hangover Part II | - | - | - | $1,401,308 | 54 | $1,401,308 | May 26 | Warner Bros. | false |
| 11 | Mr. Popper's Penguins | - | - | - | $1,231,948 | 46 | $1,235,462 | Jun 23 | 20th Century Fox International | false |
| 12 | Violeta Went to Heaven | - | - | - | $1,190,077 | 41 | $1,190,077 | Aug 11 | - | false |
| 13 | Green Lantern | - | - | - | $1,121,215 | 135 | $1,121,215 | Aug 11 | Warner Bros. | false |
| 14 | Zookeeper | - | - | - | $1,008,536 | 36 | $1,008,536 | Jul 21 | Sony Pictures Releasing | false |
| 15 | Battle Los Angeles | - | - | - | $1,002,152 | 29 | $1,002,152 | Mar 10 | Sony Pictures Releasing | false |
| 16 | X-Men: First Class | - | - | - | $779,126 | 70 | $992,642 | Jun 2 | 20th Century Fox International | false |
| 17 | Rio | - | - | - | $646,216 | 88 | $1,378,695 | Apr 7 | 20th Century Fox International | false |
| 18 | Thor | - | - | - | $612,267 | 95 | $1,249,402 | Apr 28 | United International Pictures | false |
| 19 | Super 8 | - | - | - | $562,930 | 48 | $562,930 | Aug 4 | United International Pictures | false |
| 20 | The Tourist | - | - | - | $562,391 | 36 | $562,391 | Feb 10 | Sony Pictures Releasing | false |
| 21 | The Green Hornet | - | - | - | $551,640 | 82 | $551,640 | Jan 20 | Sony Pictures Releasing | false |
| 22 | Just Go with It | - | - | - | $435,619 | 30 | $435,619 | Apr 14 | Sony Pictures Releasing | false |
| 23 | Horrible Bosses | - | - | - | $371,353 | 20 | $372,527 | Jul 21 | Warner Bros. | false |
| 24 | The Rite | - | - | - | $278,047 | 53 | $1,019,423 | Feb 17 | Warner Bros. | false |
| 25 | Friends with Benefits | - | - | - | $273,256 | 22 | $274,444 | Sep 29 | Sony Pictures Releasing | false |
| 26 | Bad Teacher | - | - | - | $244,837 | 20 | $244,837 | Sep 8 | Sony Pictures Releasing | false |
| 27 | Priest | - | - | - | $234,867 | 80 | $234,867 | May 12 | Sony Pictures Releasing | false |
| 28 | Gnomeo & Juliet | - | - | - | $215,559 | 43 | $215,559 | May 5 | - | false |
| 29 | Crazy, Stupid, Love. | - | - | - | $177,668 | 17 | $177,668 | Aug 18 | Warner Bros. | false |
| 30 | Source Code | - | - | - | $150,073 | 20 | $150,073 | Aug 18 | - | false |
| 31 | Scream 4 | - | - | - | $144,680 | 28 | $144,680 | Jun 16 | - | false |
| 32 | Season of the Witch | - | - | - | $143,393 | 16 | $143,393 | Jul 7 | - | false |
| 33 | Yogi Bear | - | - | - | $126,334 | 45 | $1,327,106 | Feb 3 | Warner Bros. | false |
| 34 | Cowboys & Aliens | - | - | - | $126,318 | 43 | $126,318 | Aug 25 | United International Pictures | false |
| 35 | The King's Speech | - | - | - | $102,958 | 25 | $347,653 | Feb 17 | - | false |
| 36 | Burlesque | - | - | - | $100,640 | 20 | $106,385 | Feb 3 | Sony Pictures Releasing | false |
| 37 | Midnight in Paris | - | - | - | $97,832 | 19 | $97,832 | Aug 25 | - | false |
| 38 | Black Swan | - | - | - | $84,650 | 30 | $1,122,992 | Jan 27 | 20th Century Fox International | false |
| 39 | I Am Number Four | - | - | - | $77,921 | 28 | $120,327 | Feb 24 | Walt Disney Pictures | false |
| 40 | Big Mommas: Like Father, Like Son | - | - | - | $66,836 | 20 | $66,836 | May 12 | 20th Century Fox International | false |
| 41 | The Beaver | - | - | - | $65,034 | 10 | $65,034 | Aug 4 | - | false |
| 42 | Jackass 3D | - | - | - | $54,196 | 26 | $94,721 | Feb 24 | United International Pictures | false |
| 43 | No Strings Attached | - | - | - | $47,527 | 26 | $186,069 | Feb 17 | United International Pictures | false |
| 44 | Winnie the Pooh | - | - | - | $44,862 | 15 | $44,862 | Jun 23 | Walt Disney Pictures | false |
| 45 | Water for Elephants | - | - | - | $44,515 | 21 | $132,678 | Apr 28 | 20th Century Fox International | false |
| 46 | The Next Three Days | - | - | - | $34,948 | 15 | $34,948 | May 12 | - | false |
| 47 | The Crazies | - | - | - | $31,190 | 18 | $53,057 | Feb 24 | - | false |
| 48 | The Collector | - | - | - | $29,473 | 16 | $29,473 | Aug 25 | - | false |
| 49 | The Social Network | - | - | - | $26,688 | 27 | $331,704 | Oct 28 | Sony Pictures Releasing | false |
| 50 | 127 Hours | - | - | - | $23,455 | 20 | $318,318 | Feb 3 | 20th Century Fox International | false |
| 51 | The Greatest | - | - | - | $17,218 | 2 | $17,218 | Jul 21 | - | false |
| 52 | Mother and Child | - | - | - | $13,742 | 9 | $13,742 | May 5 | - | false |
| 53 | Love & Other Drugs | - | - | - | $12,409 | 17 | $183,305 | Feb 10 | 20th Century Fox International | false |
| 54 | Torrente 4: Lethal Crisis | - | - | - | $7,694 | 18 | $7,694 | Aug 25 | - | false |
| 55 | Eat Pray Love | - | - | - | $812 | 17 | $437,918 | Oct 14 | Sony Pictures Releasing | false |
| 56 | The Other Guys | - | - | - | $417 | 27 | $74,302 | Dec 2 | Sony Pictures Releasing | false |
