| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Harry Potter and the Deathly Hallows: Part 1 | - | - | - | $6,134,213 | 115 | $6,149,448 | Nov 19 | Warner Bros. | false |
| 2 | Iron Man 2 | - | - | - | $4,487,383 | 99 | $4,487,383 | Apr 30 | United International Pictures | false |
| 3 | Prince of Persia: The Sands of Time | - | - | - | $3,657,048 | 80 | $4,105,296 | May 26 | Walt Disney Pictures | false |
| 4 | The Karate Kid | - | - | - | $3,346,220 | 50 | $3,346,220 | Jun 10 | Sony Pictures Releasing | false |
| 5 | The Last Airbender | - | - | - | $3,184,805 | 60 | $3,185,064 | Aug 4 | United International Pictures | false |
| 6 | Clash of the Titans | - | - | - | $2,936,796 | 116 | $3,164,699 | Apr 1 | Warner Bros. | false |
| 7 | Salt | - | - | - | $2,612,235 | 60 | $2,612,235 | Jul 28 | Sony Pictures Releasing | false |
| 8 | Avatar | - | - | - | $2,471,296 | 87 | $5,809,653 | Dec 17 | 20th Century Fox International | false |
| 9 | Inception | - | - | - | $2,381,245 | 70 | $2,439,468 | Jul 16 | Warner Bros. | false |
| 10 | Toy Story 3 | - | - | - | $2,328,606 | 81 | $2,433,492 | Jun 17 | Walt Disney Pictures | false |
| 11 | Tron: Legacy | - | - | - | $2,024,197 | 110 | $2,467,545 | Dec 17 | Walt Disney Pictures | false |
| 12 | Alice in Wonderland | - | - | - | $1,984,401 | 70 | $2,047,959 | Mar 4 | Walt Disney Pictures | false |
| 13 | Sherlock Holmes | - | - | - | $1,948,941 | 45 | $2,163,216 | Dec 30 | Warner Bros. | false |
| 14 | The Sorcerer's Apprentice | - | - | - | $1,804,555 | 60 | $2,007,847 | Jul 21 | Walt Disney Pictures | false |
| 15 | Shrek Forever After | - | - | - | $1,621,226 | 63 | $1,621,226 | May 21 | United International Pictures | false |
| 16 | How to Train Your Dragon | - | - | - | $1,560,733 | 68 | $1,560,733 | Mar 26 | United International Pictures | false |
| 17 | Despicable Me | - | - | - | $1,493,972 | 71 | $1,494,925 | Jul 9 | United International Pictures | false |
| 18 | Eat Pray Love | - | - | - | $1,476,834 | 40 | $1,530,403 | Oct 13 | Sony Pictures Releasing | false |
| 19 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $1,459,654 | 58 | $1,554,109 | Feb 10 | 20th Century Fox International | false |
| 20 | Robin Hood | - | - | - | $1,457,624 | 50 | $1,880,555 | May 12 | United International Pictures | false |
| 21 | Tangled | - | - | - | $1,325,179 | 70 | $1,894,079 | Dec 1 | Walt Disney Pictures | false |
| 22 | Megamind | - | - | - | $1,260,778 | 65 | $1,260,778 | Nov 5 | United International Pictures | false |
| 23 | The Wolfman | - | - | - | $1,101,085 | 63 | $1,101,085 | Feb 17 | United International Pictures | false |
| 24 | Green Zone | - | - | - | $905,152 | 44 | $1,032,116 | Mar 12 | United International Pictures | false |
| 25 | Sex and the City 2 | - | - | - | $788,217 | 50 | $919,926 | Jun 2 | Warner Bros. | false |
| 26 | Takers 2010 Re-release | - | - | - | $719,530 | 50 | $758,427 | Oct 27 | Sony Pictures Releasing | false |
| 27 | Legion | - | - | - | $635,820 | 35 | $723,331 | Jan 27 | Sony Pictures Releasing | false |
| 28 | Cats & Dogs: The Revenge of Kitty Galore | - | - | - | $632,353 | 46 | $632,353 | Aug 21 | Warner Bros. | false |
| 29 | Resident Evil: Afterlife | - | - | - | $588,583 | 53 | $588,583 | Sep 21 | Independent Films | false |
| 30 | The Book of Eli | - | - | - | $580,221 | 20 | $630,714 | Apr 14 | Sony Pictures Releasing | false |
| 31 | Shutter Island | - | - | - | $573,782 | 34 | $772,735 | Mar 3 | United International Pictures | false |
| 32 | Legend of the Guardians: The Owls of Ga'Hoole | - | - | - | $565,379 | 50 | $632,062 | Sep 29 | Warner Bros. | false |
| 33 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $501,100 | 30 | $1,117,869 | Dec 23 | 20th Century Fox International | false |
| 34 | Grown Ups | - | - | - | $453,889 | 15 | $488,409 | Aug 25 | Sony Pictures Releasing | false |
| 35 | Tooth Fairy | - | - | - | $451,197 | 25 | $451,197 | Jan 22 | 20th Century Fox International | false |
| 36 | Valentine's Day | - | - | - | $407,486 | 33 | $428,149 | Feb 11 | Warner Bros. | false |
| 37 | A Nightmare on Elm Street | - | - | - | $399,654 | 27 | $427,591 | May 12 | Warner Bros. | false |
| 38 | Date Night | - | - | - | $364,047 | 25 | $394,137 | Apr 21 | 20th Century Fox International | false |
| 39 | The Princess and the Frog | - | - | - | $338,069 | 32 | $338,069 | Jan 6 | Walt Disney Pictures | false |
| 40 | The Other Guys | - | - | - | $331,347 | 30 | $369,620 | Oct 6 | Sony Pictures Releasing | false |
| 41 | The Social Network | - | - | - | $321,856 | 30 | $366,544 | Nov 3 | Sony Pictures Releasing | false |
| 42 | When in Rome | - | - | - | $317,776 | 31 | $317,776 | Apr 7 | Walt Disney Pictures | false |
| 43 | Due Date | - | - | - | $281,334 | 30 | $368,517 | Dec 10 | Warner Bros. | false |
| 44 | Life as We Know It | - | - | - | $280,442 | 29 | $330,729 | Oct 22 | Warner Bros. | false |
| 45 | Paranormal Activity 2 | - | - | - | $258,509 | 18 | $415,949 | Dec 3 | United International Pictures | false |
| 46 | Cop Out | - | - | - | $225,146 | 26 | $318,420 | Apr 21 | Warner Bros. | false |
| 47 | Ninja Assassin | - | - | - | $225,112 | 50 | $1,862,728 | Nov 26 | Warner Bros. | false |
| 48 | The Bounty Hunter | - | - | - | $216,533 | 20 | $242,605 | May 5 | Sony Pictures Releasing | false |
| 49 | Devil | - | - | - | $151,694 | 24 | $303,702 | Dec 15 | United International Pictures | false |
| 50 | Did You Hear About the Morgans? | - | - | - | $142,627 | 25 | $157,376 | Jan 13 | Sony Pictures Releasing | false |
| 51 | Up in the Air | - | - | - | $135,632 | 13 | $154,220 | Feb 24 | United International Pictures | false |
| 52 | The Losers | - | - | - | $131,892 | 25 | $170,810 | May 28 | Warner Bros. | false |
| 53 | You Again | - | - | - | $129,158 | 25 | $173,656 | Nov 10 | Walt Disney Pictures | false |
| 54 | It's Complicated | - | - | - | $115,818 | 23 | $115,818 | Mar 24 | United International Pictures | false |
| 55 | Case 39 | - | - | - | $104,662 | 13 | $119,057 | Jan 27 | United International Pictures | false |
| 56 | The Back-up Plan | - | - | - | $104,109 | 16 | $119,377 | Aug 11 | Sony Pictures Releasing | false |
| 57 | Going the Distance | - | - | - | $78,298 | 18 | $97,943 | Oct 8 | Warner Bros. | false |
| 58 | Toy Story 2009 Re-release | - | - | - | $65,049 | 18 | $65,049 | Apr 23 | Walt Disney Pictures | false |
| 59 | The Lovely Bones | - | - | - | $60,902 | 15 | $65,710 | Apr 9 | United International Pictures | false |
| 60 | Old Dogs | - | - | - | $39,591 | 30 | $437,868 | Dec 2 | Walt Disney Pictures | false |
| 61 | Zombieland | - | - | - | $38,834 | 30 | $231,555 | Dec 9 | Sony Pictures Releasing | false |
| 62 | 2012 | - | - | - | $8,923 | 75 | $6,640,261 | Nov 13 | Sony Pictures Releasing | false |
| 63 | Predators | - | - | - | $7,184 | 3 | $789,793 | Jul 7 | 20th Century Fox International | false |
| 64 | Cloudy with a Chance of Meatballs | - | - | - | $3,467 | 41 | $667,890 | Oct 14 | Sony Pictures Releasing | false |
