| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Harry Potter and the Half-Blood Prince | - | - | - | $137,703 | 7 | $154,854 | Jul 17 | Warner Bros. | false |
| 2 | 2012 | - | - | - | $136,373 | 6 | $138,829 | Nov 13 | Sony Pictures Releasing | false |
| 3 | Ice Age: Dawn of the Dinosaurs | - | - | - | $123,730 | 7 | $130,628 | Jul 1 | 20th Century Fox International | false |
| 4 | This Is It | - | - | - | $114,398 | 7 | $118,159 | Oct 29 | Sony Pictures Releasing | false |
| 5 | Transformers: Revenge of the Fallen | - | - | - | $113,928 | 8 | $118,566 | Jun 25 | United International Pictures | false |
| 6 | Angels & Demons | - | - | - | $111,688 | 9 | $113,159 | May 15 | Sony Pictures Releasing | false |
| 7 | The Proposal | - | - | - | $98,735 | 7 | $98,735 | Aug 7 | Walt Disney Pictures | false |
| 8 | The Taking of Pelham 123 | - | - | - | $89,406 | 7 | $89,406 | Jul 31 | Sony Pictures Releasing | false |
| 9 | The Pink Panther 2 | - | - | - | $86,210 | 8 | $86,210 | Feb 27 | Sony Pictures Releasing | false |
| 10 | X-Men Origins: Wolverine | - | - | - | $80,517 | 8 | $89,017 | May 1 | 20th Century Fox International | false |
| 11 | The Twilight Saga: New Moon | - | - | - | $79,293 | 4 | $94,115 | Nov 27 | NuMetro Distribution | false |
| 12 | Terminator Salvation | - | - | - | $75,566 | 9 | $75,566 | Jun 5 | Sony Pictures Releasing | false |
| 13 | Night at the Museum: Battle of the Smithsonian | - | - | - | $73,834 | 6 | $73,834 | May 22 | 20th Century Fox International | false |
| 14 | The International | - | - | - | $62,421 | 6 | $62,421 | Mar 20 | Sony Pictures Releasing | false |
| 15 | Yes Man | - | - | - | $54,240 | 4 | $58,446 | Jan 2 | - | false |
| 16 | Public Enemies | - | - | - | $52,493 | 6 | $52,493 | Aug 14 | United International Pictures | false |
| 17 | Valkyrie | - | - | - | $50,255 | 5 | $50,255 | Jan 30 | - | false |
| 18 | Marley & Me | - | - | - | $49,543 | 6 | $49,543 | Mar 20 | 20th Century Fox International | false |
| 19 | Bride Wars | - | - | - | $49,279 | 4 | $49,279 | Jan 23 | - | false |
| 20 | G.I. Joe: The Rise of Cobra | - | - | - | $48,307 | 6 | $48,307 | Sep 25 | United International Pictures | false |
| 21 | Up | - | - | - | $46,939 | 5 | $46,939 | Jul 31 | Walt Disney Pictures | false |
| 22 | Avatar | - | - | - | $44,215 | 8 | $749,852 | Dec 18 | 20th Century Fox International | false |
| 23 | Race to Witch Mountain | - | - | - | $42,809 | 6 | $44,059 | Apr 24 | Walt Disney Pictures | false |
| 24 | Fast & Furious | - | - | - | $39,943 | 7 | $80,518 | Apr 10 | United International Pictures | false |
| 25 | Inglourious Basterds | - | - | - | $38,598 | 6 | $38,598 | Oct 9 | United International Pictures | false |
| 26 | Bedtime Stories | - | - | - | $37,958 | 6 | $37,958 | Feb 13 | - | false |
| 27 | State of Play | - | - | - | $37,018 | 5 | $37,018 | Jun 19 | United International Pictures | false |
| 28 | Australia | - | - | - | $36,740 | 6 | $57,909 | Dec 26 | - | false |
| 29 | Seven Pounds | - | - | - | $36,481 | 7 | $36,481 | Feb 13 | - | false |
| 30 | Couples Retreat | - | - | - | $35,939 | 6 | $49,279 | Nov 27 | United International Pictures | false |
| 31 | The Ugly Truth | - | - | - | $35,842 | 7 | $40,655 | Oct 16 | Sony Pictures Releasing | false |
| 32 | Monsters vs. Aliens | - | - | - | $35,783 | 4 | $35,783 | Apr 3 | United International Pictures | false |
| 33 | Duplicity | - | - | - | $34,568 | 4 | $34,568 | May 1 | United International Pictures | false |
| 34 | The Curious Case of Benjamin Button | - | - | - | $32,452 | 2 | $32,452 | Feb 6 | Warner Bros. | false |
| 35 | Ninja Assassin | - | - | - | $31,930 | 6 | $31,930 | Nov 27 | Warner Bros. | false |
| 36 | The Hangover | - | - | - | $31,781 | 5 | $57,872 | Aug 21 | Warner Bros. | false |
| 37 | Slumdog Millionaire | - | - | - | $31,722 | 2 | $47,052 | Mar 20 | - | false |
| 38 | Cloudy with a Chance of Meatballs | - | - | - | $31,650 | 5 | $33,146 | Sep 18 | Sony Pictures Releasing | false |
| 39 | Underworld: Rise of the Lycans | - | - | - | $30,266 | 7 | $30,266 | Jan 23 | - | false |
| 40 | Confessions of a Shopaholic | - | - | - | $29,876 | 5 | $47,059 | Apr 10 | Walt Disney Pictures | false |
| 41 | 12 Rounds | - | - | - | $29,874 | 3 | $29,874 | Apr 3 | 20th Century Fox International | false |
| 42 | He's Just Not That Into You | - | - | - | $29,446 | 2 | $29,446 | May 29 | - | false |
| 43 | Hannah Montana: The Movie | - | - | - | $29,109 | 5 | $29,109 | Jun 19 | Walt Disney Pictures | false |
| 44 | 17 Again | - | - | - | $26,758 | 2 | $26,758 | Jun 12 | NuMetro Distribution | false |
| 45 | Madagascar: Escape 2 Africa | - | - | - | $26,621 | 8 | $98,636 | Dec 19 | - | false |
| 46 | G-Force | - | - | - | $26,488 | 5 | $47,815 | Aug 21 | Walt Disney Pictures | false |
| 47 | District 9 | - | - | - | $24,681 | 5 | $34,078 | Aug 28 | Sony Pictures Releasing | false |
| 48 | Star Trek | - | - | - | $24,501 | 4 | $24,501 | May 8 | United International Pictures | false |
| 49 | Bolt | - | - | - | $24,306 | 6 | $24,306 | Jan 16 | - | false |
| 50 | The Day the Earth Stood Still | - | - | - | $21,372 | 6 | $69,623 | Dec 19 | - | false |
| 51 | Gran Torino | - | - | - | $21,176 | 5 | $21,176 | Mar 6 | - | false |
| 52 | Fame | - | - | - | $20,529 | 3 | $20,529 | Sep 25 | - | false |
| 53 | My Sister's Keeper | - | - | - | $20,008 | 2 | $24,731 | Oct 9 | NuMetro Distribution | false |
| 54 | Changeling | - | - | - | $17,297 | 4 | $17,297 | Jan 23 | - | false |
| 55 | The Time Traveler's Wife | - | - | - | $17,011 | 2 | $19,061 | Nov 6 | NuMetro Distribution | false |
| 56 | Notorious | - | - | - | $16,225 | 3 | $16,225 | Mar 6 | 20th Century Fox International | false |
| 57 | I Love You, Man | - | - | - | $15,421 | 3 | $15,421 | May 29 | United International Pictures | false |
| 58 | Beverly Hills Chihuahua | - | - | - | $14,985 | 6 | $14,985 | Jan 2 | - | false |
| 59 | Dragonball Evolution | - | - | - | $12,800 | 4 | $23,197 | Apr 10 | 20th Century Fox International | false |
| 60 | Revolutionary Road | - | - | - | $11,022 | 3 | $11,022 | Mar 6 | - | false |
| 61 | Surrogates | - | - | - | $9,949 | 4 | $17,781 | Nov 6 | Walt Disney Pictures | false |
| 62 | Inkheart | - | - | - | $9,542 | 2 | $9,542 | Jun 12 | - | false |
| 63 | Delhi-6 | - | - | - | $8,055 | 6 | $8,055 | Feb 20 | - | false |
| 64 | Aliens in the Attic | - | - | - | $6,290 | 2 | $10,771 | Dec 11 | 20th Century Fox International | false |
| 65 | Fighting | - | - | - | $4,177 | 3 | $4,177 | Jul 24 | United International Pictures | false |
| 66 | Body of Lies | - | - | - | $4,057 | 4 | $57,217 | Nov 28 | - | false |
| 67 | Eagle Eye | - | - | - | $4,029 | 6 | $35,968 | Dec 5 | - | false |
| 68 | Street Fighter: The Legend of Chun-Li | - | - | - | $3,320 | 1 | $3,320 | Jun 12 | - | false |
| 69 | Gamer | - | - | - | $2,747 | 2 | $8,353 | Dec 4 | NuMetro Distribution | false |
| 70 | Ghosts of Girlfriends Past | - | - | - | $2,042 | 2 | $9,132 | Jul 24 | - | false |
| 71 | Death Race | - | - | - | $993 | 5 | $20,895 | Nov 21 | - | false |
| 72 | My Best Friend's Girl | - | - | - | $779 | 1 | $21,538 | Oct 3 | - | false |
| 73 | Righteous Kill | - | - | - | $742 | 1 | $15,590 | Oct 24 | - | false |
| 74 | Quantum of Solace | - | - | - | $703 | 9 | $240,746 | Nov 7 | - | false |
| 75 | Dhoondte Reh Jaoge | - | - | - | $576 | 2 | $576 | Mar 6 | - | false |
| 76 | Hansie: A True Story | - | - | - | $419 | 2 | $6,696 | Sep 26 | - | false |
| 77 | Mamma Mia! | - | - | - | $23 | 4 | $38,556 | Oct 24 | - | false |
