| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 110 | WALL·E | - | - | - | $174 | 1 | $37,253 | Aug 6 | Walt Disney Pictures | false |
| 109 | Asterix at the Olympic Games | - | - | - | $510 | 1 | $510 | May 6 | - | false |
| 108 | Igor | - | - | - | $1,410 | 1 | $1,410 | Apr 1 | - | false |
| 107 | Quantum of Solace | - | - | - | $2,312 | 8 | $328,809 | Nov 5 | - | false |
| 106 | Punisher: War Zone | - | - | - | $4,526 | 5 | $39,332 | Dec 17 | - | false |
| 105 | The Flight Before Christmas | - | - | - | $5,232 | 2 | $5,232 | Oct 14 | - | false |
| 104 | Blood: The Last Vampire | - | - | - | $5,915 | 3 | $5,915 | Oct 14 | - | false |
| 103 | City of Ember | - | - | - | $7,946 | 3 | $7,946 | Mar 25 | - | false |
| 102 | Dance Flick | - | - | - | $8,105 | 5 | $8,105 | Nov 4 | United International Pictures | false |
| 101 | Killshot | - | - | - | $8,325 | 3 | $8,325 | Apr 8 | - | false |
| 100 | Aliens in the Attic | - | - | - | $9,379 | 3 | $9,379 | Sep 30 | 20th Century Fox International | false |
| 99 | The Stepfather | - | - | - | $11,481 | 5 | $20,563 | Dec 23 | Sony Pictures Releasing | false |
| 98 | Smother | - | - | - | $13,459 | 4 | $13,459 | Apr 1 | - | false |
| 97 | Bolt | - | - | - | $14,762 | 2 | $31,973 | Dec 17 | Walt Disney Pictures | false |
| 96 | The Broken | - | - | - | $15,327 | 3 | $15,327 | Jan 21 | - | false |
| 95 | Role Models | - | - | - | $15,784 | 5 | $15,784 | Mar 4 | - | false |
| 94 | Dragonball Evolution | - | - | - | $16,712 | 5 | $16,712 | Apr 15 | 20th Century Fox International | false |
| 93 | Coraline | - | - | - | $17,051 | 4 | $17,051 | Jun 3 | United International Pictures | false |
| 92 | Love Happens | - | - | - | $17,274 | 2 | $49,301 | Dec 23 | - | false |
| 91 | Journey to the Center of the Earth | - | - | - | $17,481 | 5 | $17,481 | Mar 11 | - | false |
| 90 | Slaughter | - | - | - | $20,957 | 3 | $20,957 | Sep 9 | - | false |
| 89 | The Other Man | - | - | - | $21,369 | 5 | $21,369 | Sep 30 | - | false |
| 88 | Eagle Eye | - | - | - | $21,427 | 7 | $107,146 | Dec 10 | - | false |
| 87 | It's Alive | - | - | - | $23,936 | 5 | $23,936 | May 6 | - | false |
| 86 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $24,625 | 4 | $150,925 | Dec 23 | 20th Century Fox International | false |
| 85 | Race to Witch Mountain | - | - | - | $24,629 | 5 | $24,629 | Mar 11 | Walt Disney Pictures | false |
| 84 | Cirque du Freak: The Vampire's Assistant | - | - | - | $24,913 | 5 | $42,000 | Dec 9 | United International Pictures | false |
| 83 | I Love You, Man | - | - | - | $25,780 | 3 | $25,780 | Apr 15 | United International Pictures | false |
| 82 | Terminator Salvation | - | - | - | $26,141 | - | $26,141 | May 27 | - | false |
| 81 | Gran Torino | - | - | - | $26,362 | 5 | $26,362 | Mar 25 | Warner Bros. | false |
| 80 | I Hate Valentine's Day | - | - | - | $27,718 | 3 | $27,718 | Oct 14 | - | false |
| 79 | Whiteout | - | - | - | $27,966 | 5 | $27,966 | Oct 21 | Warner Bros. | false |
| 78 | Red Cliff | - | - | - | $28,670 | 5 | $28,670 | Oct 7 | - | false |
| 77 | Hotel for Dogs | - | - | - | $31,036 | 5 | $31,036 | Mar 18 | United International Pictures | false |
| 76 | Star Trek | - | - | - | $35,420 | 5 | $35,420 | May 13 | United International Pictures | false |
| 75 | The Tale of Despereaux | - | - | - | $35,574 | 5 | $35,574 | Feb 25 | United International Pictures | false |
| 74 | Four Christmases | - | - | - | $35,593 | 3 | $93,007 | Dec 17 | - | false |
| 73 | Land of the Lost | - | - | - | $35,595 | 6 | $35,595 | Sep 30 | United International Pictures | false |
| 72 | Body of Lies | - | - | - | $35,864 | 8 | $368,885 | Oct 29 | - | false |
| 71 | Obsessed | - | - | - | $37,026 | 3 | $37,026 | Aug 5 | Sony Pictures Releasing | false |
| 70 | Management | - | - | - | $37,826 | 3 | $40,535 | Oct 28 | - | false |
| 69 | Sorority Row | - | - | - | $38,700 | 5 | $38,700 | Nov 4 | - | false |
| 68 | Transporter 3 | - | - | - | $40,393 | 6 | $40,393 | Feb 25 | - | false |
| 67 | Madagascar: Escape 2 Africa | - | - | - | $40,883 | 9 | $202,391 | Nov 26 | - | false |
| 66 | Arn: The Knight Templar | - | - | - | $42,104 | 5 | $42,104 | Oct 21 | - | false |
| 65 | Jennifer's Body | - | - | - | $42,202 | 3 | $42,202 | Oct 7 | 20th Century Fox International | false |
| 64 | The International | - | - | - | $42,721 | 6 | $42,721 | Feb 18 | - | false |
| 63 | Confessions of a Shopaholic | - | - | - | $43,321 | 4 | $43,321 | Mar 18 | Walt Disney Pictures | false |
| 62 | Cloudy with a Chance of Meatballs | - | - | - | $43,761 | 3 | $43,779 | Sep 16 | Sony Pictures Releasing | false |
| 61 | Funny People | - | - | - | $43,948 | 5 | $43,948 | Oct 21 | United International Pictures | false |
| 60 | Halloween II | - | - | - | $45,648 | 5 | $49,397 | Oct 28 | - | false |
| 59 | Crossing Over | - | - | - | $46,417 | 5 | $46,417 | Apr 15 | - | false |
| 58 | Outlander | - | - | - | $47,811 | 5 | $47,811 | Mar 25 | - | false |
| 57 | Changeling | - | - | - | $48,273 | 5 | $48,273 | Feb 11 | - | false |
| 56 | Quarantine | - | - | - | $53,566 | 5 | $53,566 | Jan 7 | - | false |
| 55 | G-Force | - | - | - | $54,162 | 3 | $54,162 | Jul 29 | Walt Disney Pictures | false |
| 54 | Friday the 13th | - | - | - | $56,495 | 8 | $56,495 | Apr 22 | United International Pictures | false |
| 53 | Monsters vs. Aliens | - | - | - | $57,227 | 8 | $57,227 | Apr 1 | United International Pictures | false |
| 52 | This Is It | - | - | - | $58,350 | 6 | $58,350 | Oct 28 | Sony Pictures Releasing | false |
| 51 | Seven Pounds | - | - | - | $58,645 | 4 | $58,645 | Feb 25 | - | false |
| 50 | Bedtime Stories | - | - | - | $59,741 | 3 | $81,150 | Dec 24 | - | false |
| 49 | Imagine That | - | - | - | $64,548 | 4 | $64,548 | Aug 5 | United International Pictures | false |
| 48 | Hannah Montana: The Movie | - | - | - | $67,815 | 4 | $67,815 | Apr 8 | Walt Disney Pictures | false |
| 47 | Revolutionary Road | - | - | - | $70,278 | 6 | $70,278 | Feb 25 | United International Pictures | false |
| 46 | Push | - | - | - | $71,981 | 5 | $71,981 | Apr 8 | - | false |
| 45 | Gamer | - | - | - | $72,864 | 7 | $72,864 | Sep 16 | - | false |
| 44 | 12 Rounds | - | - | - | $76,607 | 5 | $76,607 | Apr 1 | 20th Century Fox International | false |
| 43 | Paul Blart: Mall Cop | - | - | - | $77,578 | 8 | $77,578 | Apr 15 | Sony Pictures Releasing | false |
| 42 | Australia | - | - | - | $79,287 | 5 | $117,276 | Dec 24 | - | false |
| 41 | Case 39 | - | - | - | $79,362 | 8 | $94,084 | Nov 25 | United International Pictures | false |
| 40 | Couples Retreat | - | - | - | $80,785 | 6 | $98,269 | Nov 25 | United International Pictures | false |
| 39 | The Uninvited | - | - | - | $81,705 | 8 | $81,705 | Apr 29 | United International Pictures | false |
| 38 | Duplicity | - | - | - | $81,989 | 8 | $81,989 | May 6 | United International Pictures | false |
| 37 | Underworld: Rise of the Lycans | - | - | - | $84,621 | 4 | $84,621 | Feb 4 | - | false |
| 36 | Marley & Me | - | - | - | $86,445 | 8 | $134,871 | Mar 4 | 20th Century Fox International | false |
| 35 | State of Play | - | - | - | $86,835 | 6 | $86,835 | May 20 | United International Pictures | false |
| 34 | Watchmen | - | - | - | $90,697 | 8 | $90,697 | Mar 11 | United International Pictures | false |
| 33 | G.I. Joe: The Rise of Cobra | - | - | - | $102,586 | 8 | $102,586 | Sep 23 | United International Pictures | false |
| 32 | The Taking of Pelham 123 | - | - | - | $110,031 | 6 | $110,031 | Jun 10 | Sony Pictures Releasing | false |
| 31 | The Unborn | - | - | - | $110,822 | 8 | $110,822 | Mar 25 | United International Pictures | false |
| 30 | Orphan | - | - | - | $118,110 | 5 | $119,269 | Sep 30 | Warner Bros. | false |
| 29 | Surrogates | - | - | - | $130,045 | 6 | $130,897 | Oct 7 | Walt Disney Pictures | false |
| 28 | House | - | - | - | $130,953 | 5 | $130,953 | Mar 18 | - | false |
| 27 | Public Enemies | - | - | - | $133,686 | 8 | $133,686 | Jul 29 | United International Pictures | false |
| 26 | Bride Wars | - | - | - | $134,290 | 4 | $134,437 | Feb 4 | - | false |
| 25 | Up | - | - | - | $134,983 | 2 | $134,983 | Jun 3 | Walt Disney Pictures | false |
| 24 | The Pink Panther 2 | - | - | - | $145,228 | 6 | $145,228 | Feb 11 | - | false |
| 23 | Inglourious Basterds | - | - | - | $145,799 | 8 | $145,799 | Oct 14 | United International Pictures | false |
| 22 | Taken | - | - | - | $164,076 | 6 | $164,076 | Mar 4 | - | false |
| 21 | Valkyrie | - | - | - | $171,690 | 4 | $172,805 | Jan 21 | - | false |
| 20 | The Hangover | - | - | - | $182,942 | 3 | $182,942 | Jul 29 | Warner Bros. | false |
| 19 | The Day the Earth Stood Still | - | - | - | $196,087 | 8 | $198,367 | Dec 31 | - | false |
| 18 | The Ugly Truth | - | - | - | $205,939 | 6 | $206,681 | Sep 23 | Sony Pictures Releasing | false |
| 17 | X-Men Origins: Wolverine | - | - | - | $209,143 | 8 | $209,143 | Apr 29 | 20th Century Fox International | false |
| 16 | Knowing | - | - | - | $225,334 | 8 | $264,358 | Apr 22 | - | false |
| 15 | The Final Destination | - | - | - | $241,454 | 5 | $241,454 | Sep 16 | Warner Bros. | false |
| 14 | Fast & Furious | - | - | - | $243,650 | 8 | $243,650 | Apr 8 | United International Pictures | false |
| 13 | Ice Age: Dawn of the Dinosaurs | - | - | - | $248,319 | 5 | $248,319 | Jul 1 | 20th Century Fox International | false |
| 12 | Night at the Museum: Battle of the Smithsonian | - | - | - | $248,342 | 8 | $248,342 | May 20 | 20th Century Fox International | false |
| 11 | Twilight | - | - | - | $250,788 | 6 | $250,788 | Jan 14 | - | false |
| 10 | A Christmas Carol | - | - | - | $257,922 | 6 | $289,234 | Nov 18 | Walt Disney Pictures | false |
| 9 | Angels & Demons | - | - | - | $263,363 | 8 | $263,363 | May 13 | Sony Pictures Releasing | false |
| 8 | Yes Man | - | - | - | $269,878 | 7 | $273,105 | Jan 7 | - | false |
| 7 | Transformers: Revenge of the Fallen | - | - | - | $286,975 | 8 | $286,975 | Jun 24 | United International Pictures | false |
| 6 | The Proposal | - | - | - | $295,599 | 3 | $295,599 | Jun 24 | Walt Disney Pictures | false |
| 5 | Harry Potter and the Half-Blood Prince | - | - | - | $368,559 | 6 | $371,186 | Jul 15 | Warner Bros. | false |
| 4 | The Curious Case of Benjamin Button | - | - | - | $385,605 | 8 | $385,605 | Feb 18 | Warner Bros. | false |
| 3 | Avatar | - | - | - | $402,217 | 8 | $2,369,317 | Dec 16 | 20th Century Fox International | false |
| 2 | The Twilight Saga: New Moon | - | - | - | $503,314 | 8 | $537,535 | Nov 25 | - | false |
| 1 | 2012 | - | - | - | $974,651 | 8 | $1,101,387 | Nov 11 | Sony Pictures Releasing | false |
