| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | The Dark Knight | - | - | - | $530,924,926 | 4,366 | $533,345,358 | Jul 18 | Warner Bros. | false |
| 2 | Iron Man | - | - | - | $318,313,199 | 4,154 | $318,604,126 | May 2 | Paramount Pictures | false |
| 3 | Indiana Jones and the Kingdom of the Crystal Skull | - | - | - | $317,101,119 | 4,264 | $317,101,119 | May 22 | Paramount Pictures | false |
| 52 | I Am Legend | - | - | - | $57,047,856 | 3,648 | $256,393,010 | Dec 14 | Warner Bros. | false |
| 4 | Hancock | - | - | - | $227,946,274 | 3,965 | $227,946,274 | Jul 2 | Sony Pictures Releasing | false |
| 5 | WALL·E | - | - | - | $223,790,612 | 3,992 | $223,808,164 | Jun 27 | Walt Disney Studios Motion Pictures | false |
| 31 | National Treasure: Book of Secrets | - | - | - | $86,700,433 | 3,832 | $219,964,115 | Dec 21 | Walt Disney Studios Motion Pictures | false |
| 41 | Alvin and the Chipmunks | - | - | - | $70,249,659 | 3,499 | $217,326,974 | Dec 14 | Twentieth Century Fox | false |
| 6 | Kung Fu Panda | - | - | - | $215,434,591 | 4,136 | $215,434,591 | Jun 6 | DreamWorks | false |
| 8 | Twilight | - | - | - | $170,672,976 | 3,649 | $192,769,854 | Nov 21 | Summit Entertainment | false |
| 7 | Madagascar: Escape 2 Africa | - | - | - | $175,687,934 | 4,065 | $180,010,950 | Nov 7 | DreamWorks | false |
| 9 | Quantum of Solace | - | - | - | $165,258,802 | 3,501 | $168,368,427 | Nov 14 | Sony Pictures Releasing | false |
| 10 | Horton Hears a Who! | - | - | - | $154,529,439 | 3,961 | $154,529,439 | Mar 14 | Twentieth Century Fox | false |
| 11 | Sex and the City | - | - | - | $152,647,258 | 3,325 | $152,647,258 | May 30 | Warner Bros. | false |
| 179 | Gran Torino | - | - | - | $5,881,093 | 3,045 | $148,095,302 | Dec 12 | Warner Bros. | false |
| 12 | Mamma Mia! | - | - | - | $144,130,063 | 3,194 | $144,290,968 | Jul 18 | Universal Pictures | false |
| 17 | Juno | - | - | - | $115,568,813 | 2,534 | $143,495,265 | Dec 5 | - | false |
| 38 | Marley & Me | - | - | - | $72,444,071 | 3,505 | $143,153,751 | Dec 25 | Twentieth Century Fox | false |
| 13 | The Chronicles of Narnia: Prince Caspian | - | - | - | $141,621,490 | 3,929 | $141,621,490 | May 16 | Walt Disney Studios Motion Pictures | false |
| 117 | Slumdog Millionaire | - | - | - | $22,227,362 | 2,943 | $141,319,928 | Nov 12 | - | false |
| 14 | The Incredible Hulk | - | - | - | $134,806,913 | 3,508 | $134,806,913 | Jun 13 | Universal Pictures | false |
| 15 | Wanted | - | - | - | $134,508,551 | 3,185 | $134,508,551 | Jun 27 | Universal Pictures | false |
| 16 | Get Smart | - | - | - | $130,319,208 | 3,915 | $130,319,208 | Jun 20 | Warner Bros. | false |
| 245 | American Gangster | - | - | - | $1,086,055 | 3,110 | $130,164,645 | Nov 2 | Universal Pictures | false |
| 129 | Enchanted | - | - | - | $15,662,788 | 3,730 | $127,807,262 | Nov 21 | Walt Disney Studios Motion Pictures | false |
| 55 | The Curious Case of Benjamin Button | - | - | - | $52,666,148 | 2,988 | $127,509,326 | Dec 25 | Paramount Pictures | false |
| 214 | Bee Movie | - | - | - | $2,280,787 | 3,984 | $126,631,277 | Nov 2 | DreamWorks | false |
| 18 | Four Christmases | - | - | - | $114,136,302 | 3,540 | $120,146,040 | Nov 26 | Warner Bros. | false |
| 20 | Bolt | - | - | - | $105,380,479 | 3,654 | $114,053,579 | Nov 21 | Walt Disney Studios Motion Pictures | false |
| 19 | Tropic Thunder | - | - | - | $110,515,313 | 3,473 | $110,515,313 | Aug 13 | DreamWorks | false |
| 54 | Bedtime Stories | - | - | - | $56,700,912 | 3,684 | $110,101,975 | Dec 25 | Walt Disney Studios Motion Pictures | false |
| 21 | The Mummy: Tomb of the Dragon Emperor | - | - | - | $102,491,776 | 3,778 | $102,491,776 | Aug 1 | Universal Pictures | false |
| 22 | Journey to the Center of the Earth | - | - | - | $101,704,370 | 2,830 | $101,704,370 | Jul 11 | Warner Bros. | false |
| 23 | Eagle Eye | - | - | - | $101,198,986 | 3,614 | $101,440,743 | Sep 26 | DreamWorks | false |
| 24 | Step Brothers | - | - | - | $100,468,793 | 3,182 | $100,468,793 | Jul 25 | Sony Pictures Releasing | false |
| 25 | You Don't Mess with the Zohan | - | - | - | $100,018,837 | 3,466 | $100,018,837 | Jun 6 | Sony Pictures Releasing | false |
| 50 | Yes Man | - | - | - | $60,029,690 | 3,434 | $97,690,976 | Dec 19 | Warner Bros. | false |
| 26 | 10,000 BC | - | - | - | $94,784,201 | 3,454 | $94,784,201 | Mar 7 | Warner Bros. | false |
| 27 | Beverly Hills Chihuahua | - | - | - | $93,034,296 | 3,239 | $94,514,402 | Oct 3 | Walt Disney Studios Motion Pictures | false |
| 28 | The Bucket List | - | - | - | $92,719,141 | 2,915 | $93,466,502 | Dec 25 | Warner Bros. | false |
| 194 | Space Station 3D | - | - | - | $4,397,599 | 64 | $93,383,953 | Apr 19 | IMAX | false |
| 231 | The Game Plan | - | - | - | $1,460,932 | 3,342 | $90,648,202 | Sep 28 | Walt Disney Studios Motion Pictures | false |
| 29 | High School Musical 3: Senior Year | - | - | - | $89,682,061 | 3,626 | $90,559,416 | Oct 24 | Walt Disney Studios Motion Pictures | false |
| 30 | Pineapple Express | - | - | - | $87,341,380 | 3,072 | $87,341,380 | Aug 6 | Sony Pictures Releasing | false |
| 71 | Valkyrie | - | - | - | $40,901,858 | 2,838 | $83,077,833 | Dec 25 | United Artists | false |
| 241 | Beowulf | - | - | - | $1,151,921 | 3,249 | $82,280,579 | Nov 16 | Paramount Pictures | false |
| 32 | 21 | - | - | - | $81,159,365 | 2,952 | $81,159,365 | Mar 28 | Sony Pictures Releasing | false |
| 33 | What Happens in Vegas | - | - | - | $80,277,646 | 3,255 | $80,277,646 | May 9 | Twentieth Century Fox | false |
| 34 | Jumper | - | - | - | $80,172,128 | 3,430 | $80,172,128 | Feb 14 | Twentieth Century Fox | false |
| 35 | Cloverfield | - | - | - | $80,048,433 | 3,411 | $80,048,433 | Jan 18 | Paramount Pictures | false |
| 43 | The Day the Earth Stood Still | - | - | - | $67,286,845 | 3,560 | $79,366,978 | Dec 12 | Twentieth Century Fox | false |
| 36 | 27 Dresses | - | - | - | $76,808,654 | 3,074 | $76,808,654 | Jan 18 | Twentieth Century Fox | false |
| 37 | Hellboy II: The Golden Army | - | - | - | $75,986,503 | 3,212 | $75,986,503 | Jul 11 | Universal Pictures | false |
| 90 | No Country for Old Men | - | - | - | $32,712,541 | 2,037 | $74,283,625 | Nov 9 | Miramax | false |
| 39 | Vantage Point | - | - | - | $72,266,306 | 3,163 | $72,266,306 | Feb 22 | Sony Pictures Releasing | false |
| 273 | Fred Claus | - | - | - | $656,674 | 3,603 | $72,006,777 | Nov 9 | Warner Bros. | false |
| 40 | The Spiderwick Chronicles | - | - | - | $71,195,053 | 3,847 | $71,195,053 | Feb 14 | Paramount Pictures | false |
| 42 | Fool's Gold | - | - | - | $70,231,041 | 3,125 | $70,231,041 | Feb 8 | Warner Bros. | false |
| 152 | The Golden Compass | - | - | - | $10,244,179 | 3,528 | $70,107,728 | Dec 7 | New Line Cinema | false |
| 61 | Seven Pounds | - | - | - | $45,938,985 | 2,758 | $69,951,824 | Dec 19 | Sony Pictures Releasing | false |
| 44 | Role Models | - | - | - | $66,367,815 | 2,798 | $67,294,270 | Nov 7 | Universal Pictures | false |
| 104 | Charlie Wilson's War | - | - | - | $27,996,250 | 2,594 | $66,661,095 | Dec 21 | Universal Pictures | false |
| 45 | Hannah Montana and Miley Cyrus: Best of Both Worlds Concert | - | - | - | $65,281,781 | 687 | $65,281,781 | Feb 1 | Walt Disney Studios Motion Pictures | false |
| 46 | The Happening | - | - | - | $64,506,874 | 2,986 | $64,506,874 | Jun 13 | Twentieth Century Fox | false |
| 47 | Forgetting Sarah Marshall | - | - | - | $63,172,463 | 2,872 | $63,172,463 | Apr 18 | Universal Pictures | false |
| 48 | Baby Mama | - | - | - | $60,494,212 | 2,627 | $60,494,212 | Apr 25 | Universal Pictures | false |
| 49 | Burn After Reading | - | - | - | $60,355,347 | 2,657 | $60,355,347 | Sep 12 | Focus Features | false |
| 51 | Step Up 2: The Streets | - | - | - | $58,016,931 | 2,528 | $58,017,783 | Feb 14 | Walt Disney Studios Motion Pictures | false |
| 53 | Saw V | - | - | - | $56,746,769 | 3,084 | $56,746,769 | Oct 24 | Lionsgate Films | false |
| 103 | P.S. I Love You | - | - | - | $28,405,687 | 2,471 | $53,695,808 | Dec 21 | Warner Bros. | false |
| 502 | T-Rex: Back to the Cretaceous | - | - | - | $41,490 | 38 | $53,354,743 | Oct 23 | IMAX | false |
| 113 | Sweeney Todd: The Demon Barber of Fleet Street | - | - | - | $24,613,476 | 1,507 | $52,898,073 | Dec 21 | DreamWorks | false |
| 56 | The Strangers | - | - | - | $52,597,610 | 2,477 | $52,597,610 | May 30 | Rogue Pictures | false |
| 57 | The Forbidden Kingdom | - | - | - | $52,075,270 | 3,151 | $52,075,270 | Apr 18 | Lionsgate Films | false |
| 77 | Atonement | - | - | - | $38,888,354 | 1,400 | $50,927,067 | Dec 7 | Focus Features | false |
| 86 | The Tale of Despereaux | - | - | - | $34,019,390 | 3,107 | $50,877,145 | Dec 19 | Universal Pictures | false |
| 63 | Australia | - | - | - | $45,135,608 | 2,721 | $49,554,002 | Nov 26 | Twentieth Century Fox | false |
| 330 | This Christmas | - | - | - | $281,645 | 1,921 | $49,121,934 | Nov 21 | Screen Gems | false |
| 156 | Michael Clayton | - | - | - | $9,885,291 | 2,585 | $49,033,882 | Oct 5 | Warner Bros. | false |
| 58 | The House Bunny | - | - | - | $48,237,389 | 2,763 | $48,237,389 | Aug 22 | Sony Pictures Releasing | false |
| 59 | Nim's Island | - | - | - | $48,006,762 | 3,518 | $48,006,762 | Apr 4 | Twentieth Century Fox | false |
| 269 | Dan in Real Life | - | - | - | $698,734 | 1,941 | $47,642,963 | Oct 26 | Walt Disney Studios Motion Pictures | false |
| 203 | Deep Sea | - | - | - | $3,492,627 | 47 | $46,412,757 | Mar 3 | Warner Bros. | false |
| 60 | Made of Honor | - | - | - | $46,012,734 | 2,816 | $46,012,734 | May 2 | Sony Pictures Releasing | false |
| 62 | College Road Trip | - | - | - | $45,610,425 | 2,706 | $45,610,425 | Mar 7 | Walt Disney Studios Motion Pictures | false |
| 64 | The Sisterhood of the Traveling Pants 2 | - | - | - | $44,089,964 | 2,714 | $44,089,964 | Aug 6 | Warner Bros. | false |
| 65 | Speed Racer | - | - | - | $43,945,766 | 3,606 | $43,945,766 | May 9 | Warner Bros. | false |
| 66 | Prom Night | - | - | - | $43,869,350 | 2,821 | $43,869,350 | Apr 11 | Screen Gems | false |
| 67 | Rambo | - | - | - | $42,754,105 | 2,764 | $42,754,105 | Jan 25 | Lionsgate Films | false |
| 68 | Welcome Home, Roscoe Jenkins | - | - | - | $42,436,517 | 2,387 | $42,436,517 | Feb 8 | Universal Pictures | false |
| 69 | Meet the Browns | - | - | - | $41,975,388 | 2,016 | $41,975,388 | Mar 21 | Lionsgate Films | false |
| 70 | Nights in Rodanthe | - | - | - | $41,745,871 | 2,704 | $41,850,659 | Sep 26 | Warner Bros. | false |
| 136 | Aliens vs. Predator: Requiem | - | - | - | $13,590,647 | 2,617 | $41,797,066 | Dec 25 | Twentieth Century Fox | false |
| 118 | The Water Horse | - | - | - | $21,886,231 | 2,777 | $40,946,255 | Dec 25 | Revolution Studios | false |
| 72 | Max Payne | - | - | - | $40,662,868 | 3,381 | $40,689,393 | Oct 17 | Twentieth Century Fox | false |
| 74 | There Will Be Blood | - | - | - | $39,858,999 | 1,620 | $40,222,514 | Dec 26 | Paramount Vantage | false |
| 73 | Righteous Kill | - | - | - | $40,081,410 | 3,152 | $40,081,410 | Sep 12 | Overture Films | false |
| 294 | Hitman | - | - | - | $467,776 | 2,468 | $39,687,694 | Nov 21 | Twentieth Century Fox | false |
| 76 | Body of Lies | - | - | - | $39,203,583 | 2,714 | $39,394,666 | Oct 10 | Warner Bros. | false |
| 75 | Lakeview Terrace | - | - | - | $39,263,506 | 2,574 | $39,263,506 | Sep 19 | Screen Gems | false |
| 78 | Meet the Spartans | - | - | - | $38,233,676 | 2,643 | $38,233,676 | Jan 25 | Twentieth Century Fox | false |
| 79 | Harold & Kumar Escape from Guantanamo Bay | - | - | - | $38,108,728 | 2,545 | $38,108,728 | Apr 25 | Warner Bros. | false |
| 80 | First Sunday | - | - | - | $37,931,869 | 2,213 | $37,931,869 | Jan 11 | Screen Gems | false |
| 81 | The Secret Life of Bees | - | - | - | $37,443,851 | 1,630 | $37,770,162 | Oct 17 | - | false |
| 82 | The Family That Preys | - | - | - | $37,105,289 | 2,070 | $37,105,289 | Sep 12 | Lionsgate Films | false |
| 83 | Death Race | - | - | - | $36,316,032 | 2,586 | $36,316,032 | Aug 22 | Universal Pictures | false |
| 84 | Changeling | - | - | - | $35,598,217 | 1,896 | $35,739,802 | Oct 24 | Universal Pictures | false |
| 85 | Star Wars: The Clone Wars | - | - | - | $35,161,554 | 3,452 | $35,161,554 | Aug 15 | Warner Bros. | false |
| 227 | The Reader | - | - | - | $1,674,737 | 1,203 | $34,194,407 | Dec 10 | The Weinstein Company | false |
| 188 | Magnificent Desolation: Walking on the Moon | - | - | - | $4,875,063 | 82 | $34,137,524 | Sep 23 | IMAX | false |
| 87 | Semi-Pro | - | - | - | $33,540,654 | 3,121 | $33,479,698 | Feb 29 | New Line Cinema | false |
| 88 | Fireproof | - | - | - | $33,185,636 | 905 | $33,456,317 | Sep 26 | The Samuel Goldwyn Company | false |
| 146 | Doubt | - | - | - | $11,810,755 | 1,287 | $33,446,470 | Dec 12 | Miramax | false |
| 89 | Drillbit Taylor | - | - | - | $32,862,104 | 3,061 | $32,862,104 | Mar 21 | Paramount Pictures | false |
| 91 | Definitely, Maybe | - | - | - | $32,241,649 | 2,220 | $32,241,649 | Feb 14 | Universal Pictures | false |
| 92 | The Love Guru | - | - | - | $32,235,793 | 3,012 | $32,235,793 | Jun 20 | Paramount Pictures | false |
| 251 | Mr. Magorium's Wonder Emporium | - | - | - | $1,012,099 | 3,168 | $32,061,555 | Nov 16 | Twentieth Century Fox | false |
| 132 | Milk | - | - | - | $14,594,325 | 882 | $31,841,299 | Nov 26 | Focus Features | false |
| 94 | Transporter 3 | - | - | - | $31,675,631 | 2,626 | $31,715,062 | Nov 26 | Lionsgate Films | false |
| 93 | Quarantine | - | - | - | $31,691,811 | 2,463 | $31,691,811 | Oct 10 | Screen Gems | false |
| 229 | August Rush | - | - | - | $1,565,450 | 2,310 | $31,664,162 | Nov 21 | Warner Bros. | false |
| 95 | Nick and Norah's Infinite Playlist | - | - | - | $31,487,293 | 2,421 | $31,487,293 | Oct 3 | Sony Pictures Releasing | false |
| 98 | Zack and Miri Make a Porno | - | - | - | $31,213,743 | 2,735 | $31,457,946 | Oct 31 | The Weinstein Company | false |
| 96 | The Eye | - | - | - | $31,418,697 | 2,470 | $31,418,697 | Feb 1 | Lionsgate Films | false |
| 97 | Leatherheads | - | - | - | $31,373,938 | 2,798 | $31,373,938 | Apr 4 | Universal Pictures | false |
| 99 | Mirrors | - | - | - | $30,691,439 | 2,664 | $30,691,439 | Aug 15 | Twentieth Century Fox | false |
| 130 | The Great Debaters | - | - | - | $15,544,116 | 1,290 | $30,236,407 | Dec 25 | - | false |
| 100 | Space Chimps | - | - | - | $30,105,968 | 2,538 | $30,105,968 | Jul 18 | Twentieth Century Fox | false |
| 101 | The Bank Job | - | - | - | $30,060,660 | 1,613 | $30,060,660 | Mar 7 | Lionsgate Films | false |
| 102 | Untraceable | - | - | - | $28,687,835 | 2,368 | $28,687,835 | Jan 25 | Screen Gems | false |
| 534 | Defiance | - | - | - | $25,237 | 1,793 | $28,644,813 | Dec 31 | Paramount Vantage | false |
| 105 | The Women | - | - | - | $26,902,075 | 2,995 | $26,902,075 | Sep 12 | Picturehouse | false |
| 106 | One Missed Call | - | - | - | $26,890,041 | 2,240 | $26,890,041 | Jan 4 | Warner Bros. | false |
| 107 | The Other Boleyn Girl | - | - | - | $26,814,957 | 1,212 | $26,814,957 | Feb 29 | Sony Pictures Releasing | false |
| 108 | Street Kings | - | - | - | $26,418,667 | 2,469 | $26,418,667 | Apr 11 | - | false |
| 240 | The Wrestler | - | - | - | $1,169,379 | 776 | $26,238,243 | Dec 17 | - | false |
| 109 | Shutter | - | - | - | $25,928,550 | 2,756 | $25,928,550 | Mar 21 | Twentieth Century Fox | false |
| 110 | Superhero Movie | - | - | - | $25,874,034 | 2,965 | $25,881,068 | Mar 28 | - | false |
| 327 | The Mist | - | - | - | $294,889 | 2,423 | $25,594,957 | Nov 21 | - | false |
| 111 | W. | - | - | - | $25,534,493 | 2,050 | $25,534,493 | Oct 17 | Lionsgate Films | false |
| 112 | Never Back Down | - | - | - | $24,850,922 | 2,729 | $24,850,922 | Mar 14 | Summit Entertainment | false |
| 133 | Sea Monsters: A Prehistoric Adventure | - | - | - | $14,470,286 | 252 | $23,746,066 | Oct 5 | National Geographic Entertainment | false |
| 114 | Traitor | - | - | - | $23,530,831 | 2,108 | $23,530,831 | Aug 27 | Overture Films | false |
| 115 | Vicky Cristina Barcelona | - | - | - | $22,772,748 | 726 | $23,216,709 | Aug 15 | - | false |
| 323 | Revolutionary Road | - | - | - | $313,469 | 1,077 | $22,911,480 | Dec 26 | Paramount Vantage | false |
| 116 | Babylon A.D. | - | - | - | $22,532,572 | 3,425 | $22,532,572 | Aug 29 | Twentieth Century Fox | false |
| 119 | The X Files: I Want to Believe | - | - | - | $20,982,478 | 3,185 | $20,982,478 | Jul 25 | Twentieth Century Fox | false |
| 120 | Mad Money | - | - | - | $20,668,843 | 2,470 | $20,668,843 | Jan 18 | Overture Films | false |
| 576 | Gone Baby Gone | - | - | - | $15,134 | 1,713 | $20,300,218 | Oct 19 | Miramax | false |
| 121 | Appaloosa | - | - | - | $20,072,553 | 1,290 | $20,211,394 | Sep 19 | Warner Bros. | false |
| 139 | The Spirit | - | - | - | $13,067,406 | 2,509 | $19,806,188 | Dec 25 | Lionsgate Films | false |
| 122 | Igor | - | - | - | $19,445,931 | 2,341 | $19,528,602 | Sep 19 | Metro-Goldwyn-Mayer (MGM) | false |
| 123 | My Best Friend's Girl | - | - | - | $19,219,250 | 2,636 | $19,219,250 | Sep 19 | Lionsgate Films | false |
| 286 | Galapagos | - | - | - | $517,197 | 14 | $18,630,372 | Oct 29 | IMAX | false |
| 195 | Frost/Nixon | - | - | - | $4,369,220 | 1,105 | $18,622,031 | Dec 5 | Universal Pictures | false |
| 234 | Into the Wild | - | - | - | $1,338,007 | 660 | $18,354,356 | Sep 21 | Paramount Vantage | false |
| 184 | Walk Hard: The Dewey Cox Story | - | - | - | $5,242,050 | 2,650 | $18,317,151 | Dec 21 | Sony Pictures Releasing | false |
| 124 | Kit Kittredge: An American Girl | - | - | - | $17,657,973 | 1,849 | $17,657,973 | Jun 20 | Picturehouse | false |
| 125 | The Ruins | - | - | - | $17,432,844 | 2,814 | $17,432,844 | Apr 4 | DreamWorks | false |
| 126 | 88 Minutes | - | - | - | $17,213,467 | 2,168 | $17,213,467 | Apr 18 | Sony Pictures Releasing | false |
| 381 | Wild Safari - A South African Adventure | - | - | - | $145,826 | 21 | $16,621,530 | Apr 8 | - | false |
| 127 | Swing Vote | - | - | - | $16,289,867 | 2,213 | $16,289,867 | Aug 1 | Walt Disney Studios Motion Pictures | false |
| 155 | The Kite Runner | - | - | - | $9,950,597 | 715 | $15,800,078 | Dec 14 | Paramount Vantage | false |
| 128 | Pride and Glory | - | - | - | $15,740,721 | 2,585 | $15,740,721 | Oct 24 | Warner Bros. | false |
| 131 | Bangkok Dangerous | - | - | - | $15,298,133 | 2,654 | $15,298,133 | Sep 5 | Lionsgate Films | false |
| 451 | Lions for Lambs | - | - | - | $67,914 | 2,216 | $15,002,854 | Nov 9 | United Artists | false |
| 355 | Last Chance Harvey | - | - | - | $208,007 | 1,108 | $14,889,042 | Dec 25 | Overture Films | false |
| 322 | Awake | - | - | - | $315,358 | 2,023 | $14,377,198 | Nov 30 | - | false |
| 134 | Disaster Movie | - | - | - | $14,190,901 | 2,642 | $14,190,901 | Aug 29 | Lionsgate Films | false |
| 135 | The Duchess | - | - | - | $13,848,978 | 1,207 | $13,848,978 | Sep 19 | Paramount Vantage | false |
| 143 | Fly Me to the Moon 3D | - | - | - | $12,518,732 | 713 | $13,816,982 | Aug 15 | Summit Entertainment | false |
| 382 | Haunted Castle | - | - | - | $145,797 | 10 | $13,651,656 | Feb 23 | - | false |
| 137 | The Haunting of Molly Hartley | - | - | - | $13,482,372 | 2,652 | $13,559,812 | Oct 31 | Freestyle Releasing | false |
| 138 | Ghost Town | - | - | - | $13,367,624 | 1,512 | $13,367,624 | Sep 19 | DreamWorks | false |
| 140 | Religulous | - | - | - | $13,011,160 | 568 | $13,011,160 | Oct 1 | Lionsgate Films | false |
| 141 | The Pirates Who Don't Do Anything | - | - | - | $12,981,269 | 1,340 | $12,981,269 | Jan 11 | Universal Pictures | false |
| 153 | Rachel Getting Married | - | - | - | $10,104,295 | 391 | $12,796,841 | Oct 3 | Sony Pictures Classics | false |
| 142 | Under the Same Moon | - | - | - | $12,590,147 | 454 | $12,590,147 | Mar 19 | The Weinstein Company | false |
| 144 | Miss Pettigrew Lives for a Day | - | - | - | $12,313,694 | 539 | $12,313,694 | Mar 7 | Focus Features | false |
| 145 | Soul Men | - | - | - | $12,017,328 | 2,048 | $12,082,391 | Nov 7 | - | false |
| 351 | The Darjeeling Limited | - | - | - | $214,119 | 698 | $11,902,715 | Sep 29 | - | false |
| 147 | Meet Dave | - | - | - | $11,803,254 | 3,011 | $11,803,254 | Jul 11 | Twentieth Century Fox | false |
| 148 | The Longshots | - | - | - | $11,537,046 | 2,089 | $11,537,046 | Aug 22 | - | false |
| 149 | Be Kind Rewind | - | - | - | $11,184,916 | 810 | $11,175,164 | Feb 22 | New Line Cinema | false |
| 150 | Doomsday | - | - | - | $11,008,770 | 1,938 | $11,008,770 | Mar 14 | Rogue Pictures | false |
| 151 | Stop-Loss | - | - | - | $10,915,744 | 1,305 | $10,915,744 | Mar 28 | Paramount Pictures | false |
| 225 | Roving Mars | - | - | - | $1,746,374 | 27 | $10,407,978 | Jan 27 | Walt Disney Studios Motion Pictures | false |
| 158 | U2 3D | - | - | - | $9,642,269 | 686 | $10,363,341 | Jan 23 | National Geographic Entertainment | false |
| 344 | La Vie En Rose | - | - | - | $229,406 | 178 | $10,301,706 | Jun 8 | Picturehouse | false |
| 154 | Penelope | - | - | - | $10,011,996 | 1,207 | $10,011,996 | Feb 29 | Summit Entertainment | false |
| 157 | The Express | - | - | - | $9,793,406 | 2,810 | $9,793,406 | Oct 10 | Universal Pictures | false |
| 159 | Smart People | - | - | - | $9,511,289 | 1,119 | $9,511,289 | Apr 11 | Miramax | false |
| 160 | The Visitor | - | - | - | $9,427,089 | 270 | $9,427,089 | Apr 11 | Overture Films | false |
| 161 | The Boy in the Striped Pajamas | - | - | - | $8,721,222 | 679 | $9,046,156 | Nov 7 | Miramax | false |
| 707 | Death at a Funeral | - | - | - | $843 | 324 | $8,580,428 | Aug 17 | Metro-Goldwyn-Mayer (MGM) | false |
| 162 | Sex Drive | - | - | - | $8,402,485 | 2,421 | $8,402,485 | Oct 17 | Summit Entertainment | false |
| 166 | Cadillac Records | - | - | - | $7,844,196 | 701 | $8,195,551 | Dec 5 | Sony Pictures Releasing | false |
| 296 | Bella | - | - | - | $466,014 | 457 | $8,070,537 | Oct 26 | Roadside Attractions | false |
| 163 | Punisher: War Zone | - | - | - | $8,050,977 | 2,508 | $8,050,977 | Dec 5 | Lionsgate Films | false |
| 164 | Miracle at St. Anna | - | - | - | $7,919,117 | 1,185 | $7,919,117 | Sep 26 | Walt Disney Studios Motion Pictures | false |
