| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Max Th | Opening | % of Total
| Open Th | Open | Close | Distributor
| Estimated
|
|---|
| 1 | Kung Fu Panda | - | - | - | $3,211,192 | - | - | - | - | Jun 13 | - | - | false |
| 2 | The Dark Knight | - | - | - | $2,784,330 | - | - | - | - | Jul 18 | - | - | false |
| 3 | The Mummy: Tomb of the Dragon Emperor | - | - | - | $2,783,656 | - | - | - | - | Aug 1 | - | - | false |
| 4 | Quantum of Solace | - | - | - | $2,518,434 | - | - | - | - | Nov 5 | - | - | false |
| 5 | Iron Man | - | - | - | $2,147,484 | - | - | - | - | Apr 30 | - | - | false |
| 6 | Indiana Jones and the Kingdom of the Crystal Skull | - | - | - | $1,855,894 | - | - | - | - | May 22 | - | - | false |
| 7 | The Chronicles of Narnia: Prince Caspian | - | - | - | $1,818,504 | - | - | - | - | May 15 | - | - | false |
| 8 | Hancock | - | - | - | $1,662,556 | - | - | - | - | Jul 2 | - | - | false |
| 9 | Wanted | - | - | - | $1,624,517 | - | - | - | - | Jul 9 | - | - | false |
| 10 | Madagascar: Escape 2 Africa | - | - | - | $1,558,368 | - | - | - | - | Dec 24 | - | - | false |
| 11 | The Incredible Hulk | - | - | - | $1,498,269 | - | - | - | - | Jun 18 | - | - | false |
| 12 | Jumper | - | - | - | $1,104,195 | - | - | - | - | Feb 15 | - | - | false |
| 13 | 10,000 BC | - | - | - | $1,035,237 | - | - | - | - | Mar 6 | - | - | false |
| 14 | Bedtime Stories | - | - | - | $921,206 | - | - | - | - | Dec 31 | - | - | false |
| 15 | WALL·E | - | - | - | $902,360 | - | - | - | - | Aug 13 | - | - | false |
| 16 | Aliens vs. Predator: Requiem | - | - | - | $748,182 | - | - | - | - | Jan 3 | - | - | false |
| 17 | The Day the Earth Stood Still | - | - | - | $743,625 | - | - | - | - | Dec 12 | - | - | false |
| 18 | Bolt | - | - | - | $723,640 | - | - | - | - | Dec 3 | - | - | false |
| 19 | CJ7 | - | - | - | $659,130 | - | - | - | - | Feb 6 | - | - | false |
| 20 | Babylon A.D. | - | - | - | $632,211 | - | - | - | - | Sep 3 | - | - | false |
| 21 | Eagle Eye | - | - | - | $565,702 | - | - | - | - | Oct 15 | - | - | false |
| 22 | Get Smart | - | - | - | $544,752 | - | - | - | - | Jun 25 | - | - | false |
| 23 | Vantage Point | - | - | - | $523,942 | - | - | - | - | Mar 12 | - | - | false |
| 24 | Sex and the City | - | - | - | $515,124 | - | - | - | - | Jun 20 | - | - | false |
| 25 | Body of Lies | - | - | - | $509,120 | - | - | - | - | Oct 10 | - | - | false |
| 26 | Death Race | - | - | - | $505,283 | - | - | - | - | Aug 27 | - | - | false |
| 27 | The Spiderwick Chronicles | - | - | - | $496,237 | - | - | - | - | Mar 20 | - | - | false |
| 28 | Speed Racer | - | - | - | $484,569 | - | - | - | - | May 9 | - | - | false |
| 29 | Max Payne | - | - | - | $480,034 | - | - | - | - | Oct 22 | - | - | false |
| 30 | High School Musical 3: Senior Year | - | - | - | $475,084 | - | - | - | - | Oct 29 | - | - | false |
| 31 | Mamma Mia! | - | - | - | $466,768 | - | - | - | - | Sep 17 | - | - | false |
| 32 | Journey to the Center of the Earth | - | - | - | $446,730 | - | - | - | - | Nov 15 | - | - | false |
| 33 | Hellboy II: The Golden Army | - | - | - | $440,522 | - | - | - | - | Sep 10 | - | - | false |
| 34 | Alvin and the Chipmunks | - | - | - | $422,956 | - | - | - | - | Jan 18 | - | - | false |
| 35 | Horton Hears a Who! | - | - | - | $415,679 | - | - | - | - | Mar 14 | - | - | false |
| 36 | Street Kings | - | - | - | $410,492 | - | - | - | - | Apr 11 | - | - | false |
| 37 | What Happens in Vegas | - | - | - | $394,011 | - | - | - | - | May 7 | - | - | false |
| 38 | The X Files: I Want to Believe | - | - | - | $390,552 | - | - | - | - | Jul 24 | - | - | false |
| 39 | The Water Horse | - | - | - | $349,439 | - | - | - | - | Feb 22 | - | - | false |
| 40 | American Gangster | - | - | - | $347,173 | - | - | - | - | Jan 16 | - | - | false |
| 41 | The Happening | - | - | - | $316,460 | - | - | - | - | Jun 11 | - | - | false |
| 42 | Shutter | - | - | - | $297,020 | - | - | - | - | Jun 6 | - | - | false |
| 43 | Meet the Spartans | - | - | - | $281,627 | - | - | - | - | Feb 1 | - | - | false |
| 44 | Mirrors | - | - | - | $265,066 | - | - | - | - | Aug 15 | - | - | false |
| 45 | Made of Honor | - | - | - | $261,454 | - | - | - | - | Jun 5 | - | - | false |
| 46 | Australia | - | - | - | $256,655 | 5 | - | - | - | Dec 24 | - | 20th Century Fox International | false |
| 47 | Meet Dave | - | - | - | $246,420 | - | - | - | - | Jul 11 | - | - | false |
| 48 | Cloverfield | - | - | - | $231,413 | - | - | - | - | Feb 20 | - | - | false |
| 49 | Beverly Hills Chihuahua | - | - | - | $220,212 | - | - | - | - | Nov 12 | - | - | false |
| 50 | 27 Dresses | - | - | - | $219,344 | - | - | - | - | Feb 27 | - | - | false |
| 51 | Fool's Gold | - | - | - | $199,459 | - | - | - | - | Apr 9 | - | - | false |
| 52 | One Missed Call | - | - | - | $152,403 | - | - | - | - | Apr 2 | - | - | false |
| 53 | Tropic Thunder | - | - | - | $149,883 | - | - | - | - | Nov 21 | - | - | false |
| 54 | Quarantine | - | - | - | $142,024 | - | - | - | - | Dec 19 | - | - | false |
| 55 | 21 | - | - | - | $116,270 | - | - | - | - | Jun 12 | - | - | false |
| 56 | Nights in Rodanthe | - | - | - | $104,607 | - | - | - | - | Nov 26 | - | - | false |
| 57 | Star Wars: The Clone Wars | - | - | - | $99,063 | - | - | - | - | Aug 20 | - | - | false |
| 58 | 1408 | - | - | - | $98,641 | - | - | - | - | Jan 9 | - | - | false |
| 59 | Shoot 'Em Up | - | - | - | $92,987 | - | - | - | - | Mar 22 | - | - | false |
| 60 | August Rush | - | - | - | $86,009 | - | - | - | - | Jan 9 | - | - | false |
| 61 | The House Bunny | - | - | - | $85,949 | - | - | - | - | Oct 17 | - | - | false |
| 62 | Space Chimps | - | - | - | $35,573 | - | - | - | - | Sep 27 | - | - | false |
| 63 | No Country for Old Men | - | - | - | $31,056 | - | - | - | - | May 16 | - | - | false |
| 64 | Atonement | - | - | - | $30,300 | - | - | - | - | Apr 4 | - | - | false |
