| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | Avatar | - | - | - | $1,227,126 | 21 | $2,029,219 | Dec 17 | 20th Century Fox International | false |
| 2 | Shrek Forever After | - | - | - | $634,741 | 19 | $634,741 | May 27 | United International Pictures | false |
| 3 | Sex and the City 2 | - | - | - | $525,119 | 17 | $525,119 | Jun 3 | Warner Bros. | false |
| 4 | Harry Potter and the Deathly Hallows: Part 1 | - | - | - | $504,341 | 16 | $547,275 | Nov 18 | Warner Bros. | false |
| 5 | The Twilight Saga: Eclipse | - | - | - | $473,623 | 15 | $473,623 | Jul 1 | - | false |
| 6 | Inception | - | - | - | $387,317 | 14 | $387,317 | Jul 22 | Warner Bros. | false |
| 7 | Alice in Wonderland | - | - | - | $336,719 | 14 | $336,719 | Mar 4 | Walt Disney Pictures | false |
| 8 | How to Train Your Dragon | - | - | - | $326,252 | 17 | $326,252 | Apr 1 | United International Pictures | false |
| 9 | Sherlock Holmes | - | - | - | $319,527 | 10 | $419,040 | Dec 24 | Warner Bros. | false |
| 10 | Step Up 3D | - | - | - | $267,601 | 11 | $267,601 | Aug 12 | - | false |
| 11 | Arthur and the Revenge of Maltazard | - | - | - | $266,662 | 13 | $266,662 | Dec 31 | - | false |
| 12 | Eat Pray Love | - | - | - | $266,628 | 9 | $266,628 | Oct 7 | Sony Pictures Releasing | false |
| 13 | Shutter Island | - | - | - | $254,410 | 9 | $254,410 | Mar 11 | United International Pictures | false |
| 14 | Clash of the Titans | - | - | - | $243,606 | 12 | $243,606 | Apr 22 | Warner Bros. | false |
| 15 | Alpha and Omega | - | - | - | $234,430 | 8 | $234,430 | Oct 14 | - | false |
| 16 | Robin Hood | - | - | - | $222,752 | 12 | $222,752 | May 13 | United International Pictures | false |
| 17 | The Book of Eli | - | - | - | $219,043 | 9 | $219,043 | Jan 21 | - | false |
| 18 | Iron Man 2 | - | - | - | $212,418 | 11 | $212,418 | Apr 29 | United International Pictures | false |
| 19 | The Social Network | - | - | - | $210,707 | 10 | $232,284 | Oct 28 | Sony Pictures Releasing | false |
| 20 | Piranha 3D | - | - | - | $201,997 | 8 | $201,997 | Sep 16 | - | false |
| 21 | StreetDance 2 | - | - | - | $188,507 | 11 | $188,507 | Jun 24 | - | false |
| 22 | Prince of Persia: The Sands of Time | - | - | - | $185,944 | 10 | $185,944 | Jun 10 | Walt Disney Pictures | false |
| 23 | The Rebound | - | - | - | $180,949 | 7 | $180,949 | Dec 31 | - | false |
| 24 | It's Complicated | - | - | - | $179,181 | 7 | $179,181 | Jan 28 | United International Pictures | false |
| 25 | The Bounty Hunter | - | - | - | $177,844 | 12 | $177,844 | Apr 8 | Sony Pictures Releasing | false |
| 26 | Despicable Me | - | - | - | $176,053 | 10 | $176,053 | Jul 29 | United International Pictures | false |
| 27 | The Switch | - | - | - | $173,680 | 6 | $173,680 | Sep 2 | - | false |
| 28 | Due Date | - | - | - | $166,549 | 8 | $234,707 | Dec 2 | Warner Bros. | false |
| 29 | The Expendables | - | - | - | $158,448 | 5 | $158,448 | Aug 19 | - | false |
| 30 | The Princess and the Frog | - | - | - | $158,092 | 11 | $158,092 | Jan 21 | Walt Disney Pictures | false |
| 31 | Valentine's Day | - | - | - | $155,753 | 10 | $155,753 | Feb 11 | Warner Bros. | false |
| 32 | Cloudy with a Chance of Meatballs | - | - | - | $151,058 | 16 | $151,058 | Feb 4 | Sony Pictures Releasing | false |
| 33 | The Chronicles of Narnia: The Voyage of the Dawn Treader | - | - | - | $146,028 | 18 | $217,020 | Dec 9 | 20th Century Fox International | false |
| 34 | The Wolfman | - | - | - | $145,585 | 9 | $145,585 | Feb 18 | United International Pictures | false |
| 35 | Up in the Air | - | - | - | $139,985 | 7 | $139,985 | Feb 4 | United International Pictures | false |
| 36 | Megamind | - | - | - | $131,729 | 17 | $203,222 | Dec 16 | United International Pictures | false |
| 37 | Did You Hear About the Morgans? | - | - | - | $129,047 | 12 | $129,047 | Jan 14 | Sony Pictures Releasing | false |
| 38 | The Last Airbender | - | - | - | $126,758 | 9 | $126,758 | Aug 19 | United International Pictures | false |
| 39 | Resident Evil: Afterlife | - | - | - | $126,609 | 11 | $126,609 | Sep 10 | Sony Pictures Releasing | false |
| 40 | Arthur 3: The War of the Two Worlds | - | - | - | $115,004 | 9 | $115,004 | Nov 4 | - | false |
| 41 | Kick-Ass | - | - | - | $112,376 | 10 | $112,376 | Apr 15 | United International Pictures | false |
| 42 | Saw 3D | - | - | - | $112,350 | 5 | $112,350 | Oct 28 | - | false |
| 43 | RED | - | - | - | $110,923 | 6 | $113,955 | Nov 25 | - | false |
| 44 | Toy Story 3 | - | - | - | $109,298 | 15 | $109,298 | Jul 8 | Walt Disney Pictures | false |
| 45 | Remember Me | - | - | - | $108,751 | 9 | $108,751 | Mar 25 | - | false |
| 46 | The Fourth Kind | - | - | - | $104,760 | 5 | $104,760 | Dec 31 | - | false |
| 47 | Dear John | - | - | - | $99,856 | 6 | $99,856 | Feb 18 | - | false |
| 48 | Cats & Dogs: The Revenge of Kitty Galore | - | - | - | $99,111 | 10 | $99,111 | Aug 26 | Warner Bros. | false |
| 49 | The Blind Side | - | - | - | $95,404 | 6 | $95,404 | Mar 4 | Warner Bros. | false |
| 50 | The Back-up Plan | - | - | - | $94,463 | 6 | $94,463 | May 6 | Sony Pictures Releasing | false |
| 51 | The Sorcerer's Apprentice | - | - | - | $91,548 | 9 | $91,548 | Aug 5 | Walt Disney Pictures | false |
| 52 | Heartbreaker | - | - | - | $90,875 | 6 | $90,875 | Oct 21 | - | false |
| 53 | The Men Who Stare at Goats | - | - | - | $90,474 | 4 | $90,474 | Jan 7 | - | false |
| 54 | From Paris with Love | - | - | - | $89,792 | 6 | $89,792 | Mar 18 | - | false |
| 55 | Little Fockers | - | - | - | $88,042 | 13 | $304,851 | Dec 23 | United International Pictures | false |
| 56 | The Town | - | - | - | $87,580 | 5 | $87,580 | Oct 28 | Warner Bros. | false |
| 57 | Letters to Juliet | - | - | - | $87,438 | 6 | $87,438 | Jul 15 | - | false |
| 58 | Going the Distance | - | - | - | $86,840 | 8 | $86,840 | Sep 16 | Warner Bros. | false |
| 59 | Alvin and the Chipmunks: The Squeakquel | - | - | - | $83,991 | 8 | $83,991 | Feb 11 | 20th Century Fox International | false |
| 60 | Knight and Day 2010 Re-release | - | - | - | $83,795 | 14 | $83,795 | Jul 29 | 20th Century Fox International | false |
| 61 | Salt | - | - | - | $83,767 | 14 | $83,767 | Aug 19 | Sony Pictures Releasing | false |
| 62 | The Other Guys | - | - | - | $81,150 | 7 | $81,150 | Oct 14 | Sony Pictures Releasing | false |
| 63 | Predators | - | - | - | $76,508 | 8 | $76,508 | Jul 8 | 20th Century Fox International | false |
| 64 | The Spy Next Door 2010 Re-release | - | - | - | $74,826 | 5 | $74,826 | Feb 25 | - | false |
| 65 | Grown Ups | - | - | - | $72,547 | 5 | $72,547 | Jul 15 | Sony Pictures Releasing | false |
| 66 | Paranormal Activity | - | - | - | $70,475 | 5 | $70,475 | Jan 28 | - | false |
| 67 | Legend of the Guardians: The Owls of Ga'Hoole | - | - | - | $69,983 | 9 | $69,983 | Sep 30 | Warner Bros. | false |
| 68 | Leap Year | - | - | - | $67,344 | 6 | $67,344 | Mar 18 | United International Pictures | false |
| 69 | The Last Exorcism | - | - | - | $66,200 | 4 | $66,200 | Oct 7 | - | false |
| 70 | Devil | - | - | - | $64,309 | 4 | $64,309 | Oct 21 | United International Pictures | false |
| 71 | A Nightmare on Elm Street | - | - | - | $63,881 | 6 | $63,881 | May 20 | Warner Bros. | false |
| 72 | The Karate Kid | - | - | - | $63,150 | 12 | $64,070 | Sep 2 | Sony Pictures Releasing | false |
| 73 | She's Out of My League | - | - | - | $59,813 | 7 | $59,813 | Apr 15 | United International Pictures | false |
| 74 | The Lovely Bones | - | - | - | $58,794 | 7 | $58,794 | Feb 25 | United International Pictures | false |
| 75 | Machete | - | - | - | $56,743 | 5 | $56,743 | Oct 7 | - | false |
| 76 | A Turtle's Tale: Sammy's Adventures | - | - | - | $55,002 | 13 | $253,864 | Dec 23 | - | false |
| 77 | Wall Street: Money Never Sleeps | - | - | - | $53,471 | 5 | $53,471 | Nov 4 | 20th Century Fox International | false |
| 78 | Furry Vengeance | - | - | - | $52,551 | 6 | $52,551 | Jun 17 | - | false |
| 79 | Easy A | - | - | - | $50,228 | 7 | $50,228 | Nov 25 | Sony Pictures Releasing | false |
| 80 | The Hole | - | - | - | $48,279 | 6 | $48,279 | Nov 11 | - | false |
| 81 | Nine | - | - | - | $47,618 | 5 | $47,618 | Jan 14 | - | false |
| 82 | Edge of Darkness | - | - | - | $47,334 | 5 | $47,334 | Feb 25 | - | false |
| 83 | The American | - | - | - | $46,340 | 3 | $46,340 | Oct 21 | - | false |
| 84 | 13 | - | - | - | $46,001 | 7 | $46,001 | Nov 4 | - | false |
| 85 | An Education | - | - | - | $45,713 | 4 | $45,713 | Jan 21 | - | false |
| 86 | Couples Retreat | - | - | - | $43,153 | 10 | $163,400 | Dec 10 | United International Pictures | false |
| 87 | Get Him to the Greek | - | - | - | $41,897 | 6 | $41,897 | Jul 8 | United International Pictures | false |
| 88 | Life as We Know It | - | - | - | $41,855 | 10 | $79,226 | Dec 16 | Warner Bros. | false |
| 89 | Percy Jackson & the Olympians: The Lightning Thief | - | - | - | $41,723 | 6 | $41,723 | Mar 18 | 20th Century Fox International | false |
| 90 | Buried | - | - | - | $41,578 | 4 | $41,578 | Nov 18 | - | false |
| 91 | Hot Tub Time Machine | - | - | - | $41,334 | 3 | $41,334 | May 27 | - | false |
| 92 | Legion | - | - | - | $40,278 | 8 | $40,278 | Apr 1 | Sony Pictures Releasing | false |
| 93 | Law Abiding Citizen | - | - | - | $40,078 | 8 | $216,555 | Dec 3 | - | false |
| 94 | The Extraordinary Adventures of Adèle Blanc-Sec | - | - | - | $37,757 | 4 | $37,757 | Sep 16 | - | false |
| 95 | The Imaginarium of Doctor Parnassus | - | - | - | $36,813 | 3 | $36,813 | Sep 2 | - | false |
| 96 | Nothing But the Truth | - | - | - | $36,190 | 4 | $36,190 | Jan 7 | - | false |
| 97 | Charlie St. Cloud | - | - | - | $35,211 | 6 | $35,211 | Aug 26 | United International Pictures | false |
| 98 | 22 Bullets | - | - | - | $33,771 | 4 | $33,771 | May 6 | - | false |
| 99 | Marmaduke | - | - | - | $33,350 | 8 | $33,350 | Aug 12 | 20th Century Fox International | false |
| 100 | Green Zone 2010 Re-release | - | - | - | $32,874 | 6 | $32,874 | Apr 29 | United International Pictures | false |
| 101 | Centurion | - | - | - | $32,234 | 2 | $32,234 | Aug 5 | - | false |
| 102 | Management | - | - | - | $31,435 | 4 | $52,170 | Dec 24 | - | false |
| 103 | Brooklyn's Finest 2010 Re-release | - | - | - | $30,159 | 4 | $30,159 | Jun 3 | - | false |
| 104 | Invictus 2010 Re-release | - | - | - | $29,059 | 6 | $29,059 | Mar 11 | Warner Bros. | false |
| 105 | The A-Team | - | - | - | $28,169 | 7 | $28,169 | Aug 26 | 20th Century Fox International | false |
| 106 | Planet 51 | - | - | - | $27,817 | 6 | $27,817 | May 6 | - | false |
| 107 | You Will Meet a Tall Dark Stranger | - | - | - | $26,576 | 3 | $66,066 | Dec 16 | - | false |
| 108 | Daybreakers | - | - | - | $24,624 | 4 | $24,624 | Apr 8 | - | false |
| 109 | The New Daughter | - | - | - | $23,787 | 1 | $23,787 | Sep 23 | - | false |
| 110 | Vicky the Viking | - | - | - | $22,654 | 5 | $22,654 | Sep 23 | - | false |
| 111 | Nanny McPhee Returns | - | - | - | $19,673 | 6 | $19,673 | Jul 15 | United International Pictures | false |
| 112 | Repo Men | - | - | - | $19,501 | 5 | $19,501 | Jun 10 | United International Pictures | false |
| 113 | The Young Victoria | - | - | - | $19,437 | 2 | $27,188 | Mar 25 | - | false |
| 114 | Why Did I Get Married Too? | - | - | - | $19,366 | 4 | $19,366 | Aug 19 | - | false |
| 115 | 2012 | - | - | - | $19,109 | 22 | $620,088 | Nov 12 | Sony Pictures Releasing | false |
| 116 | Moon | - | - | - | $18,476 | 2 | $18,476 | Jan 28 | - | false |
| 117 | Ondine | - | - | - | $17,851 | 3 | $17,851 | Nov 25 | - | false |
| 118 | Tinker Bell and the Great Fairy Rescue | - | - | - | $16,990 | 2 | $16,990 | Aug 26 | Walt Disney Pictures | false |
| 119 | I Love You Phillip Morris | - | - | - | $15,765 | 3 | $25,786 | Jun 17 | - | false |
| 120 | Old Dogs | - | - | - | $13,140 | 5 | $49,217 | Dec 17 | Walt Disney Pictures | false |
| 121 | The Tournament | - | - | - | $12,860 | 3 | $12,860 | Jun 24 | - | false |
| 122 | The Losers | - | - | - | $12,770 | 5 | $12,770 | Aug 5 | Warner Bros. | false |
| 123 | Astro Boy | - | - | - | $12,450 | 7 | $54,139 | Dec 3 | - | false |
| 124 | Stone | - | - | - | $9,953 | 1 | $13,965 | Dec 23 | - | false |
| 125 | Che: Part One | - | - | - | $9,817 | 1 | $9,817 | Sep 9 | - | false |
| 126 | The Boys Are Back | - | - | - | $9,067 | 4 | $9,067 | Jul 1 | - | false |
| 127 | Saw VI | - | - | - | $8,907 | 4 | $52,199 | Dec 10 | - | false |
| 128 | Gainsbourg: A Heroic Life | - | - | - | $8,420 | 1 | $8,420 | Jun 24 | - | false |
| 129 | The Burning Plain | - | - | - | $8,135 | 1 | $8,135 | Sep 30 | - | false |
| 130 | Everybody's Fine | - | - | - | $7,795 | 1 | $7,795 | Feb 11 | Walt Disney Pictures | false |
| 131 | Toy Story 2 2009 Re-release | - | - | - | $7,466 | 2 | $7,466 | Apr 29 | Walt Disney Pictures | false |
| 132 | The Box | - | - | - | $7,385 | 3 | $23,793 | Dec 17 | - | false |
| 133 | Hachi: A Dog's Tale | - | - | - | $5,413 | 1 | $5,413 | Feb 18 | - | false |
| 134 | Crazy Heart | - | - | - | $4,864 | 1 | $4,864 | Mar 18 | 20th Century Fox International | false |
| 135 | In the Loop | - | - | - | $4,609 | 1 | $4,609 | May 6 | - | false |
| 136 | The Ghost Writer | - | - | - | $4,401 | 1 | $4,401 | Aug 26 | - | false |
| 137 | Baaria | - | - | - | $4,076 | 1 | $4,076 | Aug 19 | - | false |
| 138 | Departures | - | - | - | $2,596 | 1 | $2,596 | Jul 8 | - | false |
| 139 | Fantastic Mr. Fox | - | - | - | $2,160 | 1 | $2,160 | Apr 1 | 20th Century Fox International | false |
| 140 | Enter the Void | - | - | - | $1,856 | 1 | $1,856 | Dec 9 | - | false |
| 141 | Protector 2010 Re-release | - | - | - | $1,608 | 1 | $1,608 | Nov 11 | - | false |
| 142 | A Christmas Carol | - | - | - | $1,558 | 13 | $125,995 | Nov 26 | Walt Disney Pictures | false |
| 143 | Che: Part Two | - | - | - | $983 | 1 | $983 | Sep 30 | - | false |
