| Rank | Release
| Genre
| Budget
| Running Time
| Gross | Theaters | Total Gross | Release Date | Distributor
| Estimated
|
|---|
| 1 | The Bourne Ultimatum | - | - | - | $578,922 | 5 | $162,739 | Aug 31 | - | false |
| 2 | Pirates of the Caribbean: At World's End | - | - | - | $497,320 | 6 | $497,320 | May 23 | - | false |
| 3 | The Simpsons Movie | - | - | - | $387,385 | 6 | $387,385 | Jul 27 | - | false |
| 4 | Shrek the Third | - | - | - | $353,952 | 8 | $353,952 | Jun 8 | - | false |
| 5 | Harry Potter and the Order of the Phoenix | - | - | - | $251,637 | 6 | $251,637 | Jul 20 | - | false |
| 6 | Live Free or Die Hard | - | - | - | $245,556 | 5 | $245,556 | Jun 27 | - | false |
| 7 | Ratatouille | - | - | - | $239,232 | 9 | $239,232 | Aug 10 | - | false |
| 8 | Ocean's Thirteen | - | - | - | $218,645 | 4 | $218,645 | Jun 22 | - | false |
| 9 | Surf's Up | - | - | - | $160,801 | 8 | $160,801 | Sep 7 | - | false |
| 10 | Transformers | - | - | - | $140,859 | 5 | $140,859 | Aug 3 | - | false |
| 11 | Knocked Up | - | - | - | $138,068 | 3 | $149,336 | Aug 17 | - | false |
| 12 | Spider-Man 3 | - | - | - | $120,559 | 4 | $120,559 | May 4 | - | false |
| 13 | The Heartbreak Kid | - | - | - | $120,447 | 3 | $120,447 | Nov 16 | - | false |
| 14 | American Gangster | - | - | - | $120,312 | 4 | $125,048 | Nov 2 | - | false |
| 15 | Mr. Bean's Holiday | - | - | - | $115,156 | 4 | $305,362 | Mar 30 | - | false |
| 16 | I Now Pronounce You Chuck & Larry | - | - | - | $106,442 | 3 | $110,013 | Sep 28 | - | false |
| 17 | National Treasure: Book of Secrets | - | - | - | $97,589 | 6 | $264,359 | Dec 21 | - | false |
| 18 | Enchanted | - | - | - | $97,066 | 4 | $113,492 | Nov 30 | - | false |
| 19 | Saw IV | - | - | - | $94,166 | 2 | $94,166 | Oct 26 | - | false |
| 20 | Hitman | - | - | - | $90,498 | 3 | $101,028 | Nov 30 | - | false |
| 21 | Stardust | - | - | - | $77,532 | 4 | $77,532 | Oct 19 | - | false |
| 22 | Superbad | - | - | - | $75,243 | 2 | $75,243 | Oct 19 | - | false |
| 23 | No Reservations | - | - | - | $72,985 | 3 | $72,985 | Sep 7 | - | false |
| 24 | The Golden Compass | - | - | - | $72,041 | 3 | $96,192 | Dec 14 | - | false |
| 25 | Norbit | - | - | - | $71,066 | 2 | $71,066 | Apr 20 | - | false |
| 26 | Rush Hour 3 | - | - | - | $70,952 | 1 | $70,952 | Sep 21 | - | false |
| 27 | Evan Almighty | - | - | - | $63,619 | 4 | $67,716 | Jul 6 | - | false |
| 28 | Good Luck Chuck | - | - | - | $59,013 | 1 | $59,013 | Nov 2 | - | false |
| 29 | Elizabeth: The Golden Age | - | - | - | $56,672 | 2 | $56,672 | Nov 23 | - | false |
| 30 | Resident Evil: Extinction | - | - | - | $54,531 | 1 | $54,531 | Oct 5 | - | false |
| 31 | 28 Weeks Later | - | - | - | $53,861 | 3 | $53,861 | May 18 | - | false |
| 32 | The Irony of Fate 2 | - | - | - | $51,789 | 6 | $257,311 | Dec 28 | - | false |
| 33 | Fantastic Four: Rise of the Silver Surfer | - | - | - | $48,452 | 3 | $48,452 | Jun 15 | - | false |
| 34 | Death Proof | - | - | - | $46,845 | 2 | $46,845 | Jun 15 | - | false |
| 35 | Fracture | - | - | - | $46,036 | 1 | $46,036 | Jul 6 | - | false |
| 36 | 1408 | - | - | - | $45,148 | 1 | $45,148 | Jul 27 | - | false |
| 37 | Perfect Stranger | - | - | - | $44,873 | 1 | $44,873 | Apr 13 | - | false |
| 38 | Wild Hogs | - | - | - | $41,576 | 2 | $115,383 | Mar 23 | - | false |
| 39 | The Hills Have Eyes 2 | - | - | - | $40,779 | 1 | $66,422 | Apr 6 | - | false |
| 40 | Bee Movie | - | - | - | $40,441 | 3 | $75,942 | Dec 14 | - | false |
| 41 | The Nanny Diaries | - | - | - | $39,727 | 1 | $39,727 | Oct 12 | - | false |
| 42 | Hostel: Part II | - | - | - | $35,855 | 2 | $35,855 | Jun 8 | - | false |
| 43 | Shooter | - | - | - | $35,545 | 3 | $35,545 | Apr 13 | - | false |
| 44 | Lions for Lambs | - | - | - | $35,522 | 3 | $35,522 | Nov 9 | - | false |
| 45 | 300 | - | - | - | $34,913 | 3 | $180,725 | Mar 23 | - | false |
| 46 | The Kingdom | - | - | - | $33,075 | 1 | $34,102 | Oct 12 | - | false |
| 47 | Shoot 'Em Up | - | - | - | $29,697 | 2 | $29,697 | Nov 16 | - | false |
| 48 | Beowulf | - | - | - | $29,452 | 2 | $29,452 | Nov 23 | - | false |
| 49 | Next | - | - | - | $29,381 | 2 | $29,381 | May 18 | - | false |
| 50 | The Reaping | - | - | - | $29,070 | 2 | $29,070 | Apr 27 | - | false |
| 51 | Aliens vs. Predator: Requiem | - | - | - | $29,062 | 3 | $87,575 | Dec 28 | - | false |
| 52 | Hairspray | - | - | - | $27,308 | 1 | $27,308 | Aug 24 | - | false |
| 53 | Hot Fuzz | - | - | - | $26,845 | 1 | $33,975 | May 11 | - | false |
| 54 | Disturbia | - | - | - | $24,499 | 1 | $24,499 | Sep 14 | - | false |
| 55 | Planet Terror | - | - | - | $23,592 | 2 | $23,592 | Jul 13 | - | false |
| 56 | The Messengers | - | - | - | $23,301 | 2 | $23,301 | Jun 22 | - | false |
| 57 | The Seeker: The Dark Is Rising | - | - | - | $21,146 | 2 | $21,146 | Oct 26 | - | false |
| 58 | Georg | - | - | - | $21,057 | 3 | $337,712 | Oct 5 | - | false |
| 59 | 30 Days of Night | - | - | - | $20,852 | 1 | $20,852 | Nov 23 | - | false |
| 60 | The Number 23 | - | - | - | $20,742 | 2 | $20,742 | May 18 | - | false |
| 61 | The Invasion | - | - | - | $20,299 | 1 | $20,299 | Nov 2 | - | false |
| 62 | Waitress | - | - | - | $19,388 | 1 | $19,388 | Sep 21 | - | false |
| 63 | Sunshine | - | - | - | $18,693 | 1 | $18,693 | Apr 27 | - | false |
| 64 | The Brave One | - | - | - | $18,238 | 1 | $18,238 | Oct 12 | - | false |
| 65 | 3:10 to Yuma | - | - | - | $13,647 | 1 | $13,647 | Dec 7 | - | false |
| 66 | Zodiac | - | - | - | $13,595 | 1 | $13,595 | Jun 1 | - | false |
| 67 | 1612: Khroniki smutnogo vremeni | - | - | - | $12,254 | 1 | $12,254 | Nov 16 | - | false |
| 68 | TMNT | - | - | - | $10,882 | 2 | $10,882 | Apr 20 | - | false |
| 69 | Where Souls Go | - | - | - | $10,770 | 3 | $74,834 | Oct 26 | - | false |
| 70 | Rendition | - | - | - | $9,032 | 1 | $11,346 | Dec 7 | - | false |
| 71 | Trackman | - | - | - | $8,233 | 2 | $8,233 | Sep 28 | - | false |
| 72 | I Could Never Be Your Woman | - | - | - | $7,773 | 3 | $7,773 | Dec 14 | - | false |
| 73 | Epic Movie | - | - | - | $7,355 | 1 | $41,147 | Mar 16 | - | false |
| 74 | Bridge to Terabithia | - | - | - | $6,534 | 1 | $6,534 | May 11 | - | false |
| 75 | Charlotte's Web | - | - | - | $5,990 | 6 | $86,659 | Mar 16 | - | false |
| 76 | Meet the Robinsons | - | - | - | $4,850 | 1 | $9,193 | Apr 6 | - | false |
| 77 | Music and Lyrics | - | - | - | $1,532 | 3 | $67,782 | Mar 9 | - | false |
