| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Jungle Cruise | $49,624,454 | - | 4,310 | - | $11,513 | $49,624,454 | 1 | Walt Disney Studios Motion Pictures | true | false |
| 2 | 4 | Space Jam: A New Legacy | $11,808,175 | -19.5% | 3,501 | -501 | $3,372 | $63,196,000 | 3 | Warner Bros. | false | true |
| 3 | 1 | Old | $10,529,890 | -55.9% | 3,379 | +24 | $3,116 | $34,383,145 | 2 | Universal Pictures | false | false |
| 4 | 3 | Black Widow | $9,710,922 | -44.3% | 3,360 | -890 | $2,890 | $170,351,784 | 4 | Walt Disney Studios Motion Pictures | false | false |
| 5 | - | The Green Knight | $9,571,727 | - | 2,790 | - | $3,430 | $9,571,727 | 1 | A24 | true | false |
| 6 | - | Stillwater | $7,140,070 | - | 2,531 | - | $2,821 | $7,140,070 | 1 | Focus Features | true | false |
| 7 | 2 | Snake Eyes | $6,094,428 | -66.7% | 3,540 | +19 | $1,721 | $24,376,972 | 2 | Paramount Pictures | false | false |
| 8 | 5 | F9: The Fast Saga | $3,909,530 | -45.7% | 2,348 | -502 | $1,665 | $169,804,145 | 6 | Universal Pictures | false | false |
| 9 | 6 | Escape Room: Tournament of Champions | $3,438,638 | -39.7% | 2,086 | -729 | $1,648 | $21,790,370 | 3 | Sony Pictures Releasing | false | false |
| 10 | 7 | The Boss Baby 2: Family Business | $2,253,475 | -52.4% | 1,865 | -908 | $1,208 | $54,420,715 | 5 | Universal Pictures | false | false |
| 11 | 8 | The Forever Purge | $1,659,935 | -53.5% | 1,166 | -947 | $1,423 | $43,239,250 | 5 | Universal Pictures | false | false |
| 12 | 9 | A Quiet Place Part II | $936,020 | -50.7% | 779 | -618 | $1,201 | $159,106,550 | 10 | Paramount Pictures | false | false |
| 13 | 10 | Roadrunner: A Film About Anthony Bourdain | $570,925 | -58% | 537 | -417 | $1,063 | $4,801,080 | 3 | Focus Features | false | false |
| 14 | 13 | Cruella | $527,117 | -35% | 235 | -260 | $2,243 | $85,573,503 | 10 | Walt Disney Studios Motion Pictures | false | false |
| 15 | 12 | Pig | $392,467 | -58.5% | 336 | -252 | $1,168 | $2,803,679 | 3 | Neon | false | false |
| 16 | 11 | Joe Bell | $274,310 | -75% | 1,053 | -41 | $260 | $1,369,754 | 2 | Roadside Attractions | false | false |
| 17 | 14 | Hitman's Wife's Bodyguard | $248,926 | -48.8% | 260 | -216 | $957 | $37,833,932 | 8 | Lionsgate Films | false | false |
| 18 | 21 | Summer of Soul (...Or, When the Revolution Could Not Be Televised) | $88,835 | -46.9% | 85 | -65 | $1,045 | $2,236,616 | 6 | Searchlight Pictures | false | false |
| 19 | 19 | Zola | $86,308 | -55.6% | 114 | -115 | $757 | $4,759,090 | 6 | A24 | false | false |
| 20 | 15 | Peter Rabbit 2: The Runaway | $84,516 | -81.4% | 180 | -398 | $469 | $40,275,345 | 8 | Sony Pictures Releasing | false | false |
| 21 | 23 | Once I Was Engaged | $41,095 | -47.6% | 30 | -2 | $1,369 | $162,789 | 3 | Excel Entertainment | false | false |
| 22 | 27 | Raya and the Last Dragon | $38,405 | +8.2% | 30 | -5 | $1,280 | $54,703,006 | 22 | Walt Disney Studios Motion Pictures | false | false |
| 23 | 24 | Spirit Untamed | $36,630 | -46.7% | 738 | -157 | $49 | $17,635,215 | 9 | Universal Pictures | false | false |
| 24 | 22 | 12 Mighty Orphans | $33,880 | -60.3% | 50 | -24 | $677 | $3,494,148 | 8 | Sony Pictures Releasing | false | false |
| 25 | 26 | Queen Bees | $28,133 | -39.3% | 47 | -36 | $598 | $1,895,016 | 8 | Gravitas Ventures | false | false |
| 26 | - | Nine Days | $25,597 | - | 4 | - | $6,399 | $25,597 | 1 | Sony Pictures Classics | true | false |
| 27 | 36 | Without Getting Killed or Caught | $17,111 | +80.8% | 7 | +6 | $2,444 | $26,574 | 2 | mTuckman Media | false | false |
| 28 | 29 | Demon Slayer: Kimetsu no Yaiba - The Movie: Mugen Train | $16,934 | -21.6% | 21 | -3 | $806 | $49,501,610 | 15 | FUNimation Entertainment | false | false |
| 29 | 28 | Witnesses | $13,911 | -36.9% | 12 | -5 | $1,159 | $823,995 | 9 | Purdie Distribution | false | false |
| 30 | 31 | Settlers | $13,358 | -15.6% | 7 | -23 | $1,908 | $29,183 | 2 | IFC Films | false | false |
| 31 | 37 | The Truffle Hunters | $11,564 | +33.3% | 14 | +2 | $826 | $518,957 | 22 | Sony Pictures Classics | false | false |
| 32 | - | Lorelei | $10,127 | - | 11 | - | $920 | $10,127 | 1 | Freestyle Releasing | true | false |
| 33 | 30 | Ailey | $10,021 | -53.5% | 2 | - | $5,010 | $31,566 | 2 | Neon | false | false |
| 34 | - | Enemies of the State | $7,290 | - | 13 | - | $560 | $7,290 | 1 | IFC Films | true | false |
| 35 | 40 | The Swimming Pool 2021 Re-release | $5,216 | -33.7% | 3 | - | $1,738 | $143,080 | 12 | Rialto Distribution | false | false |
| 36 | 35 | I Carry You with Me | $5,212 | -46.2% | 18 | -26 | $289 | $165,148 | 6 | Sony Pictures Classics | false | false |
| 37 | 41 | The Loneliest Whale: The Search for 52 | $4,728 | -34.7% | 20 | - | $236 | $104,340 | 4 | Bleecker Street Media | false | false |
| 38 | 25 | CatVideoFest 2021 | $4,326 | -91.4% | 8 | -32 | $540 | $54,793 | 2 | Oscilloscope | false | false |
| 39 | - | Never Gonna Snow Again | $4,270 | - | 5 | - | $854 | $4,270 | 1 | Kino Lorber | true | false |
| 40 | - | Sabaya | $3,658 | - | 1 | - | $3,658 | $3,658 | 1 | MTV Documentary Films | true | false |
| 41 | 32 | Mandibles | $3,557 | -74.2% | 14 | -10 | $254 | $17,336 | 2 | Magnet Releasing | false | false |
| 42 | 47 | No Ordinary Man | $3,519 | -12.3% | 9 | - | $391 | $12,659 | 3 | Oscilloscope | false | false |
| 43 | 46 | Mama Weed | $3,474 | -25.5% | 8 | -2 | $434 | $25,055 | 3 | Music Box Films | false | false |
| 44 | 39 | Werewolves Within | $3,371 | -58% | 11 | -6 | $306 | $575,155 | 6 | IFC Films | false | false |
| 45 | 52 | Casanova, Last Love | $3,124 | +46.5% | 6 | +2 | $520 | $9,638 | 4 | Cohen Media Group | false | false |
| 46 | 43 | Summertime | $2,960 | -56.2% | 10 | -19 | $296 | $67,733 | 4 | Good Deed Entertainment | false | false |
| 47 | - | Lydia Lunch: The War Is Never Over | $1,740 | - | 2 | - | $870 | $9,906 | 6 | Kino Lorber | false | false |
| 48 | 44 | Dream Horse | $1,335 | -77.8% | 17 | - | $78 | $2,865,644 | 11 | Bleecker Street Media | false | false |
| 49 | 49 | Can You Bring It: Bill T. Jones and D-Man in the Waters | $1,057 | -71.5% | 4 | -3 | $264 | $8,546 | 3 | Kino Lorber | false | false |
| 50 | 57 | The Dry | $667 | -34.5% | 2 | -1 | $333 | $364,237 | 11 | IFC Films | false | false |
| 51 | 33 | Secret Agent Dingledorf and His Trusty Dog Splat | $460 | -96.5% | 3 | -27 | $153 | $13,760 | 5 | Integrity Releasing | false | false |
| 52 | 50 | The Ladykillers 2021 Re-release | $433 | -83.1% | 1 | -2 | $433 | $21,808 | 9 | Rialto Pictures | false | false |
| 53 | 42 | The Red Circle 2021 Re-release | $412 | -94.1% | 1 | -3 | $412 | $58,013 | 6 | Rialto Pictures | false | false |
| 54 | 61 | The Perfect Candidate | $207 | +269.6% | 1 | - | $207 | $28,927 | 12 | Music Box Films | false | false |
| 55 | 53 | Summer of 85 | $148 | -92.2% | 2 | -3 | $74 | $70,635 | 7 | Music Box Films | false | false |
| 56 | 59 | Shiva Baby | $32 | -78.7% | 1 | - | $32 | $156,839 | 18 | Utopia | false | false |
