| Rank | Release
| Weekly | Weekend | % of Week | Weekdays | % of Week | Theaters | Week | Distributor
| New This Week
| Estimated
|
|---|
| 1 | Space Jam: A New Legacy | $41,807,605 | $31,053,362 | 74.3% | $10,754,243 | 25.7% | 3,965 | 1 | Warner Bros. | - | false |
| 2 | Black Widow | $37,445,012 | $25,847,496 | 69% | $11,597,516 | 31% | 4,275 | 2 | Walt Disney Studios Motion Pictures | - | false |
| 3 | Escape Room: Tournament of Champions | $12,648,270 | $8,801,391 | 69.6% | $3,846,879 | 30.4% | 2,815 | 1 | Sony Pictures Releasing | - | false |
| 4 | F9: The Fast Saga | $11,477,870 | $7,673,715 | 66.9% | $3,804,155 | 33.1% | 3,368 | 4 | Universal Pictures | - | false |
| 5 | The Boss Baby 2: Family Business | $7,510,960 | $4,730,085 | 63% | $2,780,875 | 37% | 3,449 | 3 | Universal Pictures | - | false |
| 6 | The Forever Purge | $6,256,000 | $4,115,830 | 65.8% | $2,140,170 | 34.2% | 2,735 | 3 | Universal Pictures | - | false |
| 7 | A Quiet Place Part II | $3,545,753 | $2,238,015 | 63.1% | $1,307,738 | 36.9% | 1,995 | 8 | Paramount Pictures | - | false |
| 8 | Roadrunner: A Film About Anthony Bourdain | $2,871,480 | $1,988,795 | 69.3% | $882,685 | 30.7% | 927 | 1 | Focus Features | - | false |
| 9 | Cruella | $1,917,327 | $1,165,810 | 60.8% | $751,517 | 39.2% | 1,175 | 8 | Walt Disney Studios Motion Pictures | - | false |
| 10 | Pig | $1,465,932 | $970,935 | 66.2% | $494,997 | 33.8% | 552 | 1 | Neon | - | false |
| 11 | Hitman's Wife's Bodyguard | $1,200,978 | $766,474 | 63.8% | $434,504 | 36.2% | 1,034 | 6 | Lionsgate | - | false |
| 12 | Peter Rabbit 2: The Runaway | $1,043,561 | $613,490 | 58.8% | $430,071 | 41.2% | 1,117 | 6 | Sony Pictures Releasing | - | false |
| 13 | In the Heights | $602,696 | $372,297 | 61.8% | $230,399 | 38.2% | 1,405 | 6 | Warner Bros. | - | false |
| 14 | The Conjuring: The Devil Made Me Do It | $589,441 | $353,137 | 59.9% | $236,304 | 40.1% | 1,716 | 7 | Warner Bros. | - | false |
| 15 | Zola | $472,699 | $284,325 | 60.2% | $188,374 | 39.8% | 533 | 4 | A24 | - | false |
| 16 | Summer of Soul (...Or, When the Revolution Could Not Be Televised) | $289,235 | $180,985 | 62.6% | $108,250 | 37.4% | 275 | 4 | Searchlight Pictures | - | false |
| 17 | 12 Mighty Orphans | $136,731 | $88,166 | 64.5% | $48,565 | 35.5% | 140 | 6 | Sony Pictures Releasing | - | false |
| 18 | Spirit Untamed | $100,600 | $58,115 | 57.8% | $42,485 | 42.2% | 910 | 7 | Universal Pictures | - | false |
| 19 | Queen Bees | $95,392 | $53,754 | 56.4% | $41,638 | 43.6% | 123 | 6 | Gravitas Ventures | - | false |
| 20 | Demon Slayer: Kimetsu no Yaiba - The Movie: Mugen Train | $57,401 | $29,722 | 51.8% | $27,679 | 48.2% | 39 | 13 | FUNimation Entertainment | - | false |
| 21 | Once I Was Engaged | $43,220 | - | - | - | - | 28 | 1 | Excel Entertainment | - | false |
| 22 | I Carry You with Me | $41,447 | $26,356 | 63.6% | $15,091 | 36.4% | 111 | 4 | Sony Pictures Classics | - | false |
| 23 | Summertime | $36,523 | $21,650 | 59.3% | $14,873 | 40.7% | 64 | 2 | Good Deed Entertainment | - | false |
| 24 | Witnesses | $30,135 | $13,476 | 44.7% | $16,659 | 55.3% | 23 | 7 | Purdie Distribution | - | false |
| 25 | The Loneliest Whale: The Search for 52 | $28,075 | $18,903 | 67.3% | $9,172 | 32.7% | 71 | 2 | Bleecker Street Media | - | false |
| 26 | Raya and the Last Dragon | $23,540 | $15,291 | 65% | $8,249 | 35% | 41 | 20 | Walt Disney Studios Motion Pictures | - | false |
| 27 | Werewolves Within | $21,410 | $15,064 | 70.4% | $6,346 | 29.6% | 46 | 4 | IFC Films | - | false |
| 28 | Mama Weed | $16,915 | $8,891 | 52.6% | $8,024 | 47.4% | 20 | 1 | Music Box Films | - | false |
| 29 | Dream Horse | $14,283 | $9,657 | 67.6% | $4,626 | 32.4% | 30 | 9 | Bleecker Street Media | - | false |
| 30 | The Truffle Hunters | $13,078 | $8,425 | 64.4% | $4,653 | 35.6% | 15 | 20 | Sony Pictures Classics | - | false |
| 31 | Wrath of Man | $12,180 | $8,112 | 66.6% | $4,068 | 33.4% | 45 | 11 | United Artists Releasing | - | false |
| 32 | The Red Circle 2021 Re-release | $10,182 | $5,586 | 54.9% | $4,596 | 45.1% | 5 | 4 | Rialto Pictures | - | false |
| 33 | The Swimming Pool 2021 Re-release | $9,212 | $6,542 | 71% | $2,670 | 29% | 4 | 10 | Rialto Distribution | - | false |
| 34 | Rita Moreno: Just a Girl Who Decided to Go for It | $7,241 | $4,541 | 62.7% | $2,700 | 37.3% | 16 | 5 | Roadside Attractions | - | false |
| 35 | How It Ends | $6,068 | - | - | - | - | 11 | 1 | United Artists | - | false |
| 36 | Summer of 85 | $5,095 | $3,628 | 71.2% | $1,467 | 28.8% | 10 | 5 | Music Box Films | - | false |
| 37 | Rock Paper Scissors | $4,026 | $2,222 | 55.2% | $1,804 | 44.8% | 2 | 1 | Indican Pictures | - | false |
| 38 | Casanova, Last Love | $3,418 | $2,126 | 62.2% | $1,292 | 37.8% | 6 | 2 | Cohen Media Group | - | false |
| 39 | About Endlessness | $2,893 | - | - | - | - | 5 | 12 | Magnolia Pictures | - | false |
| 40 | The Dry | $2,844 | $2,012 | 70.8% | $832 | 29.2% | 5 | 9 | IFC Films | - | false |
| 41 | Shiva Baby | $2,802 | $1,037 | 37% | $1,765 | 63% | 4 | 16 | Utopia | - | false |
| 42 | Undine | $1,775 | $1,680 | 94.6% | $95 | 5.4% | 4 | 7 | IFC Films | - | false |
| 43 | A Soldier's Story 2: Return from the Dead | $499 | $297 | 59.5% | $202 | 40.5% | 1 | 4 | Indican Pictures | - | false |
| 44 | Censor | $446 | - | - | - | - | 2 | 6 | Magnolia Pictures | - | false |
| 45 | Sweat | $393 | - | - | - | - | 3 | 5 | MUBI | - | false |
| 46 | The Ladykillers 2021 Re-release | $309 | $203 | 65.7% | $106 | 34.3% | 1 | 7 | Rialto Pictures | - | false |
| 47 | The Perfect Candidate | $47 | $47 | 100% | $0 | - | 1 | 10 | Music Box Films | - | false |
