| Rank | Release
| Weekly | Weekend | % of Week | Weekdays | % of Week | Theaters | Week | Distributor
| New This Week
| Estimated
|
|---|
| 1 | Despicable Me | $85,630,895 | $56,397,125 | 65.9% | $29,233,770 | 34.1% | 3,476 | 1 | Universal Pictures | - | false |
| 2 | The Twilight Saga: Eclipse | $47,709,040 | $31,708,438 | 66.5% | $16,000,602 | 33.5% | 4,468 | 3 | Summit Entertainment | - | false |
| 3 | Predators | $33,284,041 | $24,760,882 | 74.4% | $8,523,159 | 25.6% | 2,669 | 1 | Twentieth Century Fox | - | false |
| 4 | Toy Story 3 | $32,742,203 | $21,015,958 | 64.2% | $11,726,245 | 35.8% | 3,372 | 4 | Walt Disney Studios Motion Pictures | - | false |
| 5 | Grown Ups | $24,339,548 | $15,806,738 | 64.9% | $8,532,810 | 35.1% | 3,337 | 3 | Sony Pictures Releasing | - | false |
| 6 | The Last Airbender | $24,306,168 | $16,635,471 | 68.4% | $7,670,697 | 31.6% | 3,203 | 3 | Paramount Pictures | - | false |
| 7 | Knight and Day 2010 Re-release | $11,420,520 | $7,719,251 | 67.6% | $3,701,269 | 32.4% | 2,237 | 4 | Twentieth Century Fox | - | false |
| 8 | The Karate Kid | $8,066,480 | $5,365,636 | 66.5% | $2,700,844 | 33.5% | 2,115 | 5 | Sony Pictures Releasing | - | false |
| 9 | The Sorcerer's Apprentice | $7,088,437 | - | - | - | - | 3,385 | 1 | Walt Disney Studios Motion Pictures | - | false |
| 10 | The A-Team | $2,575,010 | $1,752,421 | 68% | $822,589 | 32% | 796 | 5 | Twentieth Century Fox | - | false |
| 11 | Cyrus | $1,844,798 | $1,280,470 | 69.4% | $564,328 | 30.6% | 200 | 4 | Fox Searchlight Pictures | - | false |
| 12 | The Girl Who Played with Fire | $1,338,758 | $904,998 | 67.6% | $433,760 | 32.4% | 108 | 1 | Music Box Films | - | false |
| 13 | Get Him to the Greek | $1,123,325 | $711,625 | 63.4% | $411,700 | 36.6% | 354 | 6 | Universal Pictures | - | false |
| 14 | Shrek Forever After | $830,704 | $502,392 | 60.5% | $328,312 | 39.5% | 461 | 8 | DreamWorks | - | false |
| 15 | The Kids Are All Right | $749,507 | $491,971 | 65.6% | $257,536 | 34.4% | 7 | 1 | Focus Features | - | false |
| 16 | I Am Love | $746,888 | $503,008 | 67.4% | $243,880 | 32.6% | 111 | 4 | Magnolia Pictures | - | false |
| 17 | Winter's Bone | $660,712 | $457,547 | 69.2% | $203,165 | 30.8% | 106 | 5 | Roadside Attractions | - | false |
| 18 | Marmaduke | $624,503 | $353,815 | 56.7% | $270,688 | 43.3% | 383 | 6 | Twentieth Century Fox | - | false |
| 19 | Iron Man 2 | $612,311 | $392,755 | 64.1% | $219,556 | 35.9% | 333 | 10 | Paramount Pictures | - | false |
| 20 | Solitary Man | $582,994 | $422,502 | 72.5% | $160,492 | 27.5% | 172 | 8 | Anchor Bay Films | - | false |
| 21 | How to Train Your Dragon | $574,561 | $317,923 | 55.3% | $256,638 | 44.7% | 258 | 16 | DreamWorks | - | false |
| 22 | Hubble | $553,941 | $255,611 | 46.1% | $298,330 | 53.9% | 53 | 17 | Warner Bros. | - | false |
| 23 | Prince of Persia: The Sands of Time | $522,324 | $348,308 | 66.7% | $174,016 | 33.3% | 208 | 7 | Walt Disney Studios Motion Pictures | - | false |
| 24 | Letters to Juliet | $499,822 | $336,221 | 67.3% | $163,601 | 32.7% | 241 | 9 | Summit Entertainment | - | false |
| 25 | Robin Hood | $458,135 | $287,925 | 62.8% | $170,210 | 37.2% | 268 | 9 | Universal Pictures | - | false |
| 26 | Killers | $393,306 | $268,769 | 68.3% | $124,537 | 31.7% | 269 | 6 | Lionsgate | - | false |
| 27 | Joan Rivers: A Piece of Work | $389,752 | $255,063 | 65.4% | $134,689 | 34.6% | 115 | 5 | IFC Films | - | false |
| 28 | Sex and the City 2 | $343,209 | $208,711 | 60.8% | $134,498 | 39.2% | 156 | 8 | Warner Bros. | - | false |
| 29 | Date Night | $311,090 | $188,563 | 60.6% | $122,527 | 39.4% | 205 | 14 | Twentieth Century Fox | - | false |
| 30 | The Girl with the Dragon Tattoo | $243,213 | $150,597 | 61.9% | $92,616 | 38.1% | 91 | 17 | Music Box Films | - | false |
| 31 | Splice 2010 Re-release | $223,933 | $131,698 | 58.8% | $92,235 | 41.2% | 204 | 6 | Warner Bros. | - | false |
| 32 | The Secret in Their Eyes | $197,140 | $129,810 | 65.8% | $67,330 | 34.2% | 110 | 13 | Sony Pictures Classics | - | false |
| 33 | Please Give | $184,191 | $125,392 | 68.1% | $58,799 | 31.9% | 100 | 11 | Sony Pictures Classics | - | false |
| 34 | Coco Chanel & Igor Stravinsky | $180,361 | $115,605 | 64.1% | $64,756 | 35.9% | 47 | 5 | Sony Pictures Classics | - | false |
| 35 | I Hate Luv Storys | $169,559 | $123,836 | 73% | $45,723 | 27% | 79 | 3 | UTV Motion Pictures | - | false |
| 36 | Restrepo | $144,363 | $93,590 | 64.8% | $50,773 | 35.2% | 25 | 3 | National Geographic Entertainment | - | false |
| 37 | Clash of the Titans | $138,782 | $84,260 | 60.7% | $54,522 | 39.3% | 130 | 15 | Warner Bros. | - | false |
| 38 | Under the Sea 3D | $136,948 | $56,517 | 41.3% | $80,431 | 58.7% | 13 | 74 | Warner Bros. | - | false |
| 39 | City Island | $121,967 | $83,730 | 68.6% | $38,237 | 31.4% | 65 | 17 | Anchor Bay Films | - | false |
| 40 | Grease 2010 Sing-a-long | $102,917 | $60,759 | 59% | $42,158 | 41% | 21 | 2 | Paramount Pictures | - | false |
| 41 | Micmacs | $89,933 | $56,388 | 62.7% | $33,545 | 37.3% | 45 | 7 | Sony Pictures Classics | - | false |
| 42 | Magnificent Desolation: Walking on the Moon | $85,826 | $33,215 | 38.7% | $52,611 | 61.3% | 1 | 251 | IMAX | - | false |
| 43 | Furry Vengeance | $84,670 | $50,461 | 59.6% | $34,209 | 40.4% | 86 | 11 | Summit Entertainment | - | false |
| 44 | Just Wright | $83,359 | $53,480 | 64.2% | $29,879 | 35.8% | 80 | 9 | Fox Searchlight Pictures | - | false |
| 45 | Exit Through the Gift Shop | $76,421 | $46,021 | 60.2% | $30,400 | 39.8% | 21 | 13 | Producers Distribution Agency (PDA) | - | false |
| 46 | Wild Grass | $69,684 | $40,673 | 58.4% | $29,011 | 41.6% | 17 | 3 | Sony Pictures Classics | - | false |
| 47 | Avatar | $65,367 | $36,971 | 56.6% | $28,396 | 43.4% | 9 | 30 | Twentieth Century Fox | - | false |
| 48 | Diary of a Wimpy Kid | $63,381 | $32,305 | 51% | $31,076 | 49% | 51 | 17 | Twentieth Century Fox | - | false |
| 49 | Mother and Child | $58,419 | $38,970 | 66.7% | $19,449 | 33.3% | 44 | 10 | Sony Pictures Classics | - | false |
| 50 | The Back-up Plan | $57,619 | $36,432 | 63.2% | $21,187 | 36.8% | 61 | 12 | CBS Films | - | false |
| 51 | Jonah Hex | $56,174 | $40,382 | 71.9% | $15,792 | 28.1% | 65 | 4 | Warner Bros. | - | false |
| 52 | Ondine | $52,209 | $33,961 | 65% | $18,248 | 35% | 32 | 6 | Magnolia Pictures | - | false |
| 53 | A Nightmare on Elm Street | $44,161 | $28,805 | 65.2% | $15,356 | 34.8% | 53 | 11 | Warner Bros. | - | false |
| 54 | Harry Brown | $41,576 | $28,718 | 69.1% | $12,858 | 30.9% | 33 | 11 | The Samuel Goldwyn Company | - | false |
| 55 | South of the Border | $35,568 | $23,370 | 65.7% | $12,198 | 34.3% | 7 | 3 | Cinema Libre Studio | - | false |
| 56 | The Last Song | $35,480 | $18,889 | 53.2% | $16,591 | 46.8% | 41 | 16 | Walt Disney Studios Motion Pictures | - | false |
| 57 | Breathless 2010 Re-release | $33,567 | $19,788 | 59% | $13,779 | 41% | 6 | 7 | Rialto Pictures | - | false |
| 58 | Deep Sea | $32,604 | $17,536 | 53.8% | $15,068 | 46.2% | 2 | 228 | Warner Bros. | - | false |
| 59 | La Mission | $32,565 | $22,112 | 67.9% | $10,453 | 32.1% | 26 | 14 | Screen Media Films | - | false |
| 60 | Oceans | $31,803 | $15,890 | 50% | $15,913 | 50% | 35 | 13 | Walt Disney Studios Motion Pictures | - | false |
| 61 | Love Ranch | $27,128 | $17,945 | 66.2% | $9,183 | 33.8% | 8 | 3 | Entertainment One | - | false |
| 62 | The Killer Inside Me | $23,728 | $13,862 | 58.4% | $9,866 | 41.6% | 14 | 4 | IFC Films | - | false |
| 63 | Stonewall Uprising | $22,732 | $14,090 | 62% | $8,642 | 38% | 10 | 5 | First Run | - | false |
| 64 | Winnebago Man | $22,245 | $16,469 | 74% | $5,776 | 26% | 2 | 1 | Kino International | - | false |
| 65 | God of Vampires | $19,040 | $13,440 | 70.6% | $5,600 | 29.4% | 8 | 2 | Nocturnal Features | - | false |
| 66 | Mid-August Lunch | $18,120 | $11,572 | 63.9% | $6,548 | 36.1% | 9 | 18 | Zeitgeist Films | - | false |
| 67 | Metropolis 2010 Re-release | $17,324 | $8,716 | 50.3% | $8,608 | 49.7% | 4 | 10 | Kino International | - | false |
| 68 | The City of Your Final Destination | $12,552 | $8,480 | 67.6% | $4,072 | 32.4% | 10 | 13 | Screen Media Films | - | false |
| 69 | [Rec]² | $12,046 | $8,191 | 68% | $3,855 | 32% | 5 | 1 | Magnolia Pictures | - | false |
| 70 | Mademoiselle Chambon | $11,648 | $5,173 | 44.4% | $6,475 | 55.6% | 6 | 7 | Lorber Films | - | false |
| 71 | Princess Kaiulani | $11,592 | $8,402 | 72.5% | $3,190 | 27.5% | 6 | 9 | Roadside Attractions | - | false |
| 72 | Dogtooth | $11,572 | $5,840 | 50.5% | $5,732 | 49.5% | 2 | 3 | Kino International | - | false |
| 73 | Best Worst Movie | $9,671 | $6,704 | 69.3% | $2,967 | 30.7% | 1 | 12 | Abramorama | - | false |
| 74 | Racing Dreams | $9,632 | $5,529 | 57.4% | $4,103 | 42.6% | 1 | 8 | Hannover House | - | false |
| 75 | Around a Small Mountain | $9,218 | $5,326 | 57.8% | $3,892 | 42.2% | 1 | 1 | The Cinema Guild | - | false |
| 76 | Holy Rollers | $9,216 | $6,197 | 67.2% | $3,019 | 32.8% | 5 | 8 | First Independent Pictures | - | false |
| 77 | Sea Monsters: A Prehistoric Adventure | $7,833 | $2,909 | 37.1% | $4,924 | 62.9% | 5 | 145 | National Geographic Entertainment | - | false |
| 78 | The Oath | $7,272 | $5,196 | 71.4% | $2,076 | 28.6% | 3 | 10 | Zeitgeist Films | - | false |
| 79 | The Secret of Kells | $6,299 | $3,194 | 50.7% | $3,105 | 49.3% | 10 | 19 | GKIDS | - | false |
| 80 | Agora | $5,937 | $3,944 | 66.4% | $1,993 | 33.6% | 1 | 7 | Newmarket Films | - | false |
| 81 | In My Sleep | $5,228 | $3,911 | 74.8% | $1,317 | 25.2% | 1 | 12 | Morning Star Pictures | - | false |
| 82 | John Rabe | $5,184 | $3,301 | 63.7% | $1,883 | 36.3% | 3 | 8 | Strand Releasing | - | false |
| 83 | All About Evil | $5,070 | $5,070 | 100% | $0 | - | 1 | 1 | Peaches Christ Productions | - | false |
| 84 | Beetle Queen Conquers Tokyo | $4,931 | $2,989 | 60.6% | $1,942 | 39.4% | 2 | 10 | Argot Pictures | - | false |
| 85 | The Square 2010 Re-release | $4,408 | $3,080 | 69.9% | $1,328 | 30.1% | 5 | 14 | Apparition | - | false |
| 86 | Great Directors | $4,288 | $2,418 | 56.4% | $1,870 | 43.6% | 2 | 2 | Paladin | - | false |
| 87 | The Lottery | $4,127 | $3,432 | 83.2% | $695 | 16.8% | 2 | 5 | Variance Films | - | false |
| 88 | House | $3,817 | $1,465 | 38.4% | $2,352 | 61.6% | 3 | 26 | Janus Films | - | false |
| 89 | The Joneses | $3,693 | $2,455 | 66.5% | $1,238 | 33.5% | 1 | 13 | Roadside Attractions | - | false |
| 90 | OSS 117: Lost in Rio | $3,586 | $1,288 | 35.9% | $2,298 | 64.1% | 2 | 10 | Music Box Films | - | false |
| 91 | Cropsey | $3,466 | $2,423 | 69.9% | $1,043 | 30.1% | 3 | 6 | Cinema Purgatorio | - | false |
| 92 | The Sun Behind the Clouds: Tibet's Struggle for Freedom | $3,298 | $1,801 | 54.6% | $1,497 | 45.4% | 2 | 16 | Balcony Releasing | - | false |
| 93 | The Cremaster Cycle 2010 Re-release | $3,248 | $1,214 | 37.4% | $2,034 | 62.6% | 1 | 14 | International Film Circuit | - | false |
| 94 | The Nature of Existence | $2,985 | $2,184 | 73.2% | $801 | 26.8% | 3 | 4 | Walking Shadows | - | false |
| 95 | When You're Strange | $2,922 | - | - | - | - | 1 | 14 | Abramorama | - | false |
| 96 | 8: The Mormon Proposition | $2,733 | $1,846 | 67.5% | $887 | 32.5% | 2 | 4 | Red Flag Releasing (RFR) | - | false |
| 97 | Survival of the Dead | $2,599 | $1,914 | 73.6% | $685 | 26.4% | 2 | 7 | Magnolia Pictures | - | false |
| 98 | Sweetgrass | $2,486 | $648 | 26.1% | $1,838 | 73.9% | 2 | 28 | The Cinema Guild | - | false |
| 99 | A Town Called Panic | $2,135 | $403 | 18.9% | $1,732 | 81.1% | 1 | 31 | Zeitgeist Films | - | false |
| 100 | Alamar | $1,972 | - | - | - | - | 1 | 1 | Film Movement | - | false |
| 101 | Raajneeti | $1,726 | $1,726 | 100% | $0 | - | 5 | 6 | UTV Motion Pictures | - | false |
| 102 | Breath Made Visible: Anna Halprin | $1,654 | $1,654 | 100% | $0 | - | 1 | 15 | Argot Pictures | - | false |
| 103 | Fresh | $1,534 | - | - | - | - | 1 | 14 | Ripple Effect Films | - | false |
| 104 | Ran 2010 Re-release | $1,522 | $1,021 | 67.1% | $501 | 32.9% | 1 | 23 | Rialto Pictures | - | false |
| 105 | Only When I Dance | $1,365 | $820 | 60.1% | $545 | 39.9% | 1 | 2 | Film Movement | - | false |
| 106 | Only the Brave | $1,219 | $876 | 71.9% | $343 | 28.1% | 1 | 7 | Indican Pictures | - | false |
| 107 | Behind the Burly Q | $1,194 | $1,174 | 98.3% | $20 | 1.7% | 2 | 12 | First Run | - | false |
| 108 | Space Station 3D | $1,124 | $444 | 39.5% | $680 | 60.5% | 1 | 430 | IMAX | - | false |
| 109 | Kings of the Evening | $1,013 | $738 | 72.8% | $275 | 27.2% | 1 | 5 | Indican Pictures | - | false |
| 110 | Chloe | $994 | $577 | 58% | $417 | 42% | 2 | 16 | Sony Pictures Classics | - | false |
| 111 | Everyone Else | $646 | $562 | 87% | $84 | 13% | 1 | 14 | The Cinema Guild | - | false |
| 112 | Le Amiche | $502 | $502 | 100% | $0 | - | 1 | 4 | The Film Desk | - | false |
| 113 | Le combat dans l'île | $470 | $470 | 100% | $0 | - | 1 | 57 | The Film Desk | - | false |
| 114 | Ajami | $366 | - | - | - | - | 1 | 24 | Kino International | - | false |
| 115 | The Most Dangerous Man in America: Daniel Ellsberg and the Pentagon Papers | $343 | $343 | 100% | $0 | - | 1 | 24 | First Run | - | false |
| - | U2 3D | - | - | - | - | - | - | 130 | National Geographic Entertainment | - | false |
| - | Double Take | - | - | - | - | - | - | 7 | Kino International | - | false |
| - | Spring Fever | - | - | - | - | - | - | 6 | Strand Releasing | - | false |
| - | Videocracy | - | - | - | - | - | - | 22 | Kino International | - | false |
| - | The Living Wake | - | - | - | - | - | - | 9 | Mangusta Productions | - | false |
| - | Let it Rain | - | - | - | - | - | - | 4 | IFC Films | - | false |
| - | Two in the Wave | - | - | - | - | - | - | 9 | Lorber Films | - | false |
| - | Here and There | - | - | - | - | - | - | 9 | Cinema Purgatorio | - | false |
| - | American Grindhouse | - | - | - | - | - | - | 4 | Lorber Films | - | false |
| - | Rosencrantz and Guildenstern Are Undead | - | - | - | - | - | - | 6 | Indican Pictures | - | false |
| - | Small Change | - | - | - | - | - | - | 34 | The Film Desk | - | false |
