| TW | LW | Total | %± LW | Share | Releases | #1 Release
| Gross | % of Total | Week | Distributor
| New This Week
|
|---|
| 1 | 1 | $38,015,498 | -54.7% | 19.6% | 5 | Marley & Me | $29,959,888 | 78.8% | 3 | Twentieth Century Fox | - |
| 2 | 2 | $28,114,982 | -55.5% | 14.5% | 6 | Bedtime Stories | $23,592,144 | 83.9% | 3 | Walt Disney Studios Motion Pictures | - |
| 3 | 4 | $25,670,634 | -45.2% | 13.2% | 9 | Yes Man | $17,658,776 | 68.8% | 3 | Warner Bros. | - |
| 4 | 3 | $24,274,042 | -50.2% | 12.5% | 1 | The Curious Case of Benjamin Button | $24,274,042 | 100% | 3 | Paramount Pictures | - |
| 5 | 5 | $18,198,079 | -52.3% | 9.4% | 1 | Valkyrie | $18,198,079 | 100% | 3 | United Artists | - |
| 6 | 6 | $14,584,010 | -47.5% | 7.5% | 3 | Seven Pounds | $12,851,676 | 88.1% | 3 | Sony Pictures Releasing | - |
| 7 | 7 | $10,436,607 | -51.5% | 5.4% | 4 | The Tale of Despereaux | $8,128,385 | 77.9% | 3 | Universal Pictures | - |
| 8 | 11 | $7,097,544 | -27% | 3.7% | 3 | Slumdog Millionaire | $6,359,026 | 89.6% | 9 | Fox Searchlight Pictures | - |
| 9 | 9 | $6,978,774 | -35.6% | 3.6% | 3 | Doubt | $6,733,716 | 96.5% | 4 | Miramax | - |
| 10 | 10 | $6,390,970 | -34.6% | 3.3% | 2 | Twilight | $6,332,582 | 99.1% | 7 | Summit Entertainment | - |
| 11 | 8 | $4,403,869 | -59.5% | 2.3% | 1 | The Spirit | $4,403,869 | 100% | 3 | Lionsgate | - |
| 12 | 12 | $2,598,461 | -25.7% | 1.3% | 1 | Milk | $2,598,461 | 100% | 7 | Focus Features | - |
| 13 | 14 | $2,310,058 | +61.4% | 1.2% | 2 | The Reader | $2,208,605 | 95.6% | 5 | The Weinstein Company | - |
| 14 | 18 | $1,504,255 | +222.2% | 0.8% | 2 | Revolutionary Road | $1,340,522 | 89.1% | 2 | Paramount Vantage | - |
| 15 | 13 | $1,303,430 | -46.2% | 0.7% | 2 | Madagascar: Escape 2 Africa | $1,117,778 | 85.8% | 9 | DreamWorks | - |
| 16 | 17 | $591,224 | -11% | 0.3% | 5 | Rachel Getting Married | $238,474 | 40.3% | 14 | Sony Pictures Classics | - |
| 17 | 16 | $347,753 | -53.1% | 0.2% | 2 | Nothing Like the Holidays | $206,340 | 59.3% | 4 | Overture Films | - |
| 18 | 15 | $340,216 | -73.5% | 0.2% | 1 | Ghajini | $340,216 | 100% | 3 | Adlabs Films | - |
| 19 | 19 | $170,297 | -54.8% | <0.1% | 3 | Magnificent Desolation: Walking on the Moon | $82,219 | 48.3% | 172 | IMAX | - |
| 20 | 23 | $149,030 | +26.2% | <0.1% | 3 | Let the Right One In | $131,665 | 88.3% | 11 | Magnolia Pictures | - |
| 21 | 22 | $146,558 | -0.5% | <0.1% | 2 | Sea Monsters: A Prehistoric Adventure | $134,533 | 91.8% | 66 | National Geographic Entertainment | - |
| 22 | 21 | $146,466 | -26.7% | <0.1% | 3 | Che: Part One/Che: Part Two | $73,109 | 49.9% | 4 | IFC Films | - |
| 23 | 24 | $115,571 | +10.2% | <0.1% | 3 | Vicky Cristina Barcelona | $57,137 | 49.4% | 21 | Metro-Goldwyn-Mayer (MGM) | - |
| 24 | 20 | $86,126 | -69.4% | <0.1% | 1 | Rab Ne Bana Di Jodi | $86,126 | 100% | 4 | Yash Raj Films | - |
| 25 | 25 | $75,655 | -23.3% | <0.1% | 1 | Fireproof | $75,655 | 100% | 15 | The Samuel Goldwyn Company | - |
| 26 | 27 | $40,248 | +37% | <0.1% | 1 | Dolphins and Whales 3D: Tribes of the Ocean | $40,248 | 100% | 47 | 3D Entertainment | - |
| 27 | 28 | $37,307 | +63.2% | <0.1% | 1 | Wendy and Lucy | $37,307 | 100% | 5 | Oscilloscope | - |
| 28 | 26 | $23,232 | -25.2% | <0.1% | 1 | The Haunting of Molly Hartley | $23,232 | 100% | 10 | Freestyle Releasing | - |
| 29 | 30 | $13,272 | -15.4% | <0.1% | 2 | How About You | $7,879 | 59.4% | 8 | Strand Releasing | - |
| 30 | 34 | $12,208 | +201.2% | <0.1% | 1 | Good | $12,208 | 100% | 2 | THINKFilm | - |
| 31 | 32 | $12,124 | +29.7% | <0.1% | 2 | Antarctica | $8,167 | 67.4% | 19 | Regent Releasing | - |
| 32 | 29 | $11,968 | -24.6% | <0.1% | 1 | JCVD | $11,968 | 100% | 9 | Peace Arch Entertainment Group | - |
| 33 | 31 | $10,762 | -19.4% | <0.1% | 1 | Tell No One | $10,762 | 100% | 28 | Music Box Films | - |
| 37 | 39 | $2,506 | +50% | <0.1% | 3 | Stranded | $2,506 | 100% | 12 | Zeitgeist Films | - |
| 38 | 36 | $2,287 | -14% | <0.1% | 1 | Were the World Mine | $2,287 | 100% | 10 | SPEAK Productions | - |
| 39 | 35 | $1,208 | -59.7% | <0.1% | 1 | Lola Montès | $1,208 | 100% | 13 | Rialto Pictures | - |
| 42 | 37 | $835 | -65% | <0.1% | 1 | The Secrets | $835 | 100% | 7 | Monterey Media | - |
