| Rank | Release
| Weekly | Weekend | % of Week | Weekdays | % of Week | Theaters | Week | Distributor
| New This Week
| Estimated
|
|---|
| 1 | Apocalypto | $100,267 | - | - | - | - | 23 | 1 | 20th Century Fox International | - | false |
| 2 | Night at the Museum | $55,614 | - | - | - | - | 36 | 8 | 20th Century Fox International | - | false |
| 3 | Norbit | $46,714 | - | - | - | - | 22 | 1 | United International Pictures | - | false |
| 4 | The Holiday | $43,032 | - | - | - | - | 29 | 3 | United International Pictures | - | false |
| 5 | Pan's Labyrinth | $34,055 | - | - | - | - | 6 | 3 | Warner Bros. | - | false |
| 6 | The Departed | $32,340 | - | - | - | - | 23 | 17 | Warner Bros. | - | false |
| 7 | Blood Diamond | $30,939 | - | - | - | - | 24 | 6 | Warner Bros. | - | false |
| 8 | Babel | $27,691 | - | - | - | - | 21 | 8 | United International Pictures | - | false |
| 9 | Notes on a Scandal | $24,165 | - | - | - | - | 5 | 2 | 20th Century Fox International | - | false |
| 10 | The Pursuit of Happyness | $20,882 | - | - | - | - | 11 | 5 | Sony Pictures Releasing | - | false |
| 11 | The Illusionist | $20,526 | - | - | - | - | 14 | 9 | Transeuropa | - | false |
| 12 | The Valet | $17,677 | - | - | - | - | 14 | 1 | Transeuropa | - | false |
| 13 | Letters from Iwo Jima | $15,815 | - | - | - | - | 10 | 4 | Warner Bros. | - | false |
| 14 | The Last King of Scotland | $13,125 | - | - | - | - | 4 | 4 | 20th Century Fox International | - | false |
| 15 | Little Miss Sunshine | $8,584 | - | - | - | - | 4 | 12 | 20th Century Fox International | - | false |
| 16 | Flushed Away | $8,248 | - | - | - | - | 12 | 13 | United International Pictures | - | false |
| 17 | Deja Vu | $7,277 | - | - | - | - | 8 | 9 | Buena Vista International | - | false |
| 18 | Charlotte's Web | $6,999 | - | - | - | - | 13 | 9 | United International Pictures | - | false |
| 19 | The Tiger and the Snow | $6,714 | - | - | - | - | 9 | 3 | Bazuca Films | - | false |
| 20 | Flags of Our Fathers | $5,265 | - | - | - | - | 7 | 7 | Warner Bros. | - | false |
