| Rank | Release
| Weekly | Weekend | % of Week | Weekdays | % of Week | Theaters | Week | Distributor
| New This Week
| Estimated
|
|---|
| 1 | Night at the Museum | $653,632 | - | - | - | - | 74 | 2 | 20th Century Fox International | - | false |
| 2 | Babel | $304,169 | - | - | - | - | 40 | 2 | United International Pictures | - | false |
| 3 | Deja Vu | $199,581 | - | - | - | - | 53 | 4 | Buena Vista International | - | false |
| 4 | Flushed Away | $174,004 | - | - | - | - | 90 | 4 | United International Pictures | - | false |
| 5 | The Holiday | $113,251 | - | - | - | - | 42 | 3 | United International Pictures | - | false |
| 6 | Charlotte's Web | $108,066 | - | - | - | - | 40 | 1 | United International Pictures | - | false |
| 7 | Marie Antoinette | $103,708 | - | - | - | - | 14 | 1 | Sony Pictures Releasing | - | false |
| 8 | Eragon | $92,976 | - | - | - | - | 70 | 4 | 20th Century Fox International | - | false |
| 9 | Flags of Our Fathers | $80,762 | - | - | - | - | 15 | 1 | Warner Bros. | - | false |
| 10 | The Departed | $50,058 | - | - | - | - | 47 | 11 | Warner Bros. | - | false |
| 11 | Tenacious D in the Pick of Destiny | $47,714 | - | - | - | - | 21 | 1 | Distribution Company | - | false |
| 12 | Tsotsi | $39,430 | - | - | - | - | 14 | 1 | Alfa Films | - | false |
| 13 | The Grudge 2 | $36,134 | - | - | - | - | 39 | 3 | Alfa Films | - | false |
| 14 | Wolf Creek | $23,374 | - | - | - | - | 24 | 2 | Distribution Company | - | false |
| 15 | Little Children | $21,922 | - | - | - | - | 20 | 4 | Distribution Company | - | false |
| 16 | Casino Royale | $21,413 | - | - | - | - | 28 | 8 | Sony Pictures Releasing | - | false |
| 17 | The Prestige | $21,254 | - | - | - | - | 27 | 9 | Warner Bros. | - | false |
| 18 | Children of Men | $19,851 | - | - | - | - | 22 | 7 | United International Pictures | - | false |
| 19 | Pan's Labyrinth | $19,810 | - | - | - | - | 10 | 4 | Warner Bros. | - | false |
| 20 | Happy Feet | $18,534 | - | - | - | - | 46 | 8 | Warner Bros. | - | false |
