| Rank | Release
| Weekly | Weekend | % of Week | Weekdays | % of Week | Theaters | Week | Distributor
| New This Week
| Estimated
|
|---|
| 1 | Mr. & Mrs. Smith | $3,552,906 | - | - | - | - | 668 | 2 | SND Films | - | false |
| 2 | Transporter 2 | $3,027,070 | - | - | - | - | 510 | 1 | EuropaCorp | - | false |
| 3 | Herbie: Fully Loaded | $2,606,425 | - | - | - | - | 575 | 1 | Buena Vista International | - | false |
| 4 | Charlie and the Chocolate Factory | $2,407,104 | - | - | - | - | 670 | 4 | Warner Bros. | - | false |
| 5 | Fantastic Four | $1,863,868 | - | - | - | - | 610 | 3 | 20th Century Fox International | - | false |
| 6 | War of the Worlds | $1,342,285 | - | - | - | - | 638 | 5 | United International Pictures | - | false |
| 7 | The Skeleton Key | $1,167,434 | - | - | - | - | 247 | 1 | United International Pictures | - | false |
| 8 | Madagascar | $764,780 | - | - | - | - | 480 | 7 | United International Pictures | - | false |
| 9 | Russian Dolls | $662,446 | - | - | - | - | 340 | 8 | Mars Distribution | - | false |
| 10 | Guess Who | $568,036 | - | - | - | - | 126 | 1 | 20th Century Fox International | - | false |
| 11 | Cinderella 2005 Re-release | $264,265 | - | - | - | - | 303 | 3 | Buena Vista International | - | false |
| 12 | Shaun of the Dead | $259,957 | - | - | - | - | 106 | 2 | Mars Distribution | - | false |
| 13 | Racing Stripes | $195,638 | - | - | - | - | 300 | 2 | CTV International | - | false |
| 14 | I'm Not Scared | $157,177 | - | - | - | - | 37 | 1 | TFM Distribution | - | false |
| 15 | The Moustache | $136,623 | - | - | - | - | 122 | 5 | Pathé | - | false |
| 16 | Star Wars: Episode III - Revenge of the Sith | $123,842 | - | - | - | - | 97 | 12 | 20th Century Fox International | - | false |
| 17 | The Interpreter | $89,710 | - | - | - | - | 56 | 9 | Mars Distribution | - | false |
| 18 | The Plane | $68,621 | - | - | - | - | 103 | 3 | Pathé | - | false |
| 19 | Mindhunters | $56,637 | - | - | - | - | 33 | 5 | Gaumont | - | false |
| 20 | Blood and Bones | $48,638 | - | - | - | - | 35 | 3 | - | - | false |
