| Rank | Release
| Weekly | Weekend | % of Week | Weekdays | % of Week | Theaters | Week | Distributor
| New This Week
| Estimated
|
|---|
| 1 | Look Who's Talking | $17,878,704 | $14,147,340 | 79.1% | $3,731,364 | 20.9% | 1,547 | 2 | TriStar Pictures | - | false |
| 2 | Next of Kin | $6,158,710 | $4,805,516 | 78% | $1,353,194 | 22% | 1,358 | 1 | Warner Bros. | - | false |
| 3 | Sea of Love | $3,711,830 | $2,951,520 | 79.5% | $760,310 | 20.5% | 1,419 | 6 | Universal Pictures | - | false |
| 4 | Black Rain | $3,694,384 | $2,844,545 | 77% | $849,839 | 23% | 1,615 | 5 | Paramount Pictures | - | false |
| 5 | The Fabulous Baker Boys | $3,573,915 | $2,778,848 | 77.8% | $795,067 | 22.2% | 860 | 2 | Twentieth Century Fox | - | false |
| 6 | Halloween 5: The Revenge of Michael Myers | $3,567,884 | $2,792,611 | 78.3% | $775,273 | 21.7% | 1,495 | 2 | Galaxy International Releasing | - | false |
| 7 | Gross Anatomy | $3,550,171 | $2,830,387 | 79.7% | $719,784 | 20.3% | 853 | 1 | Walt Disney Studios Motion Pictures | - | false |
| 8 | An Innocent Man | $3,029,423 | $2,346,739 | 77.5% | $682,684 | 22.5% | 1,520 | 3 | Walt Disney Studios Motion Pictures | - | false |
| 9 | Fat Man and Little Boy | $1,943,019 | $1,476,994 | 76% | $466,025 | 24% | 843 | 1 | Paramount Pictures | - | false |
| 10 | Parenthood | $1,838,845 | $1,508,325 | 82% | $330,520 | 18% | 1,130 | 13 | Universal Pictures | - | false |
| 11 | When Harry Met Sally... | $1,491,194 | $1,114,289 | 74.7% | $376,905 | 25.3% | 1,064 | 15 | Columbia Pictures | - | false |
| 12 | Uncle Buck | $1,449,103 | $1,212,482 | 83.7% | $236,621 | 16.3% | 1,080 | 10 | Universal Pictures | - | false |
| 13 | Crimes and Misdemeanors | $1,263,443 | $925,463 | 73.2% | $337,980 | 26.8% | 68 | 2 | Orion Pictures | - | false |
| 14 | Batman | $400,889 | $299,580 | 74.7% | $101,309 | 25.3% | 353 | 18 | Warner Bros. | - | false |
| 15 | When the Whales Came | $68,455 | $37,030 | 54.1% | $31,425 | 45.9% | 10 | 1 | Twentieth Century Fox | - | false |
| - | Nightflyers | - | - | - | - | - | - | 105 | New Century | - | false |
| - | The Killing Time | - | - | - | - | - | - | 105 | New World Pictures | - | false |
| - | The Glass Menagerie | - | - | - | - | - | - | 105 | Cineplex Odeon Films | - | false |
| - | Sex, Lies, and Videotape | - | - | - | - | - | - | 12 | Miramax | - | false |
| - | The Music Teacher | - | - | - | - | - | - | 16 | Orion Classics | - | false |
| - | Breaking In | - | - | - | - | - | - | 2 | The Samuel Goldwyn Company | - | false |
