| Rank | Release
| Weekly | Weekend | % of Week | Weekdays | % of Week | Theaters | Week | Distributor
| New This Week
| Estimated
|
|---|
| 1 | Rain Man | $6,854,993 | $5,449,961 | 79.5% | $1,405,032 | 20.5% | 1,573 | 8 | Metro-Goldwyn-Mayer (MGM) | - | false |
| 2 | Three Fugitives | $6,820,149 | $5,477,051 | 80.3% | $1,343,098 | 19.7% | 1,191 | 2 | Walt Disney Studios Motion Pictures | - | false |
| 3 | Her Alibi | $6,247,278 | $5,037,047 | 80.6% | $1,210,231 | 19.4% | 1,429 | 1 | Warner Bros. | - | false |
| 4 | Beaches | $5,458,053 | $4,152,096 | 76.1% | $1,305,957 | 23.9% | 1,109 | 7 | Walt Disney Studios Motion Pictures | - | false |
| 5 | Who's Harry Crumb? | $4,671,081 | $3,862,719 | 82.7% | $808,362 | 17.3% | 1,197 | 1 | TriStar Pictures | - | false |
| 6 | Twins | $4,071,490 | $3,348,800 | 82.2% | $722,690 | 17.8% | 1,609 | 9 | Universal Pictures | - | false |
| 7 | Working Girl | $3,208,850 | $2,538,140 | 79.1% | $670,710 | 20.9% | 1,133 | 7 | Twentieth Century Fox | - | false |
| 8 | Mississippi Burning | $3,188,391 | $2,475,978 | 77.7% | $712,413 | 22.3% | 1,074 | 9 | Orion Pictures | - | false |
| 9 | The Naked Gun: From the Files of Police Squad! | $2,340,798 | $1,898,870 | 81.1% | $441,928 | 18.9% | 1,258 | 10 | Paramount Pictures | - | false |
| 10 | The Accidental Tourist | $1,895,969 | $1,539,396 | 81.2% | $356,573 | 18.8% | 756 | 7 | Warner Bros. | - | false |
| 11 | Dangerous Liaisons | $1,488,576 | $1,134,214 | 76.2% | $354,362 | 23.8% | 119 | 7 | Warner Bros. | - | false |
| 12 | Dirty Rotten Scoundrels | $1,383,818 | $1,049,115 | 75.8% | $334,703 | 24.2% | 1,106 | 8 | Orion Pictures | - | false |
| 13 | Kinjite: Forbidden Subjects | $1,312,436 | $1,029,058 | 78.4% | $283,378 | 21.6% | 320 | 1 | Cannon Film Distributors | - | false |
| - | Physical Evidence | - | $618,591 | - | - | - | - | 2 | Columbia Pictures | - | false |
| - | Cohen and Tate | - | - | - | - | - | - | 2 | Hemdale | - | false |
| - | Oliver & Company | - | - | - | - | - | - | 12 | Walt Disney Studios Motion Pictures | - | false |
| - | Parents | - | - | - | - | - | - | 2 | Vestron Pictures | - | false |
| - | Torch Song Trilogy | - | - | - | - | - | - | 8 | New Line Cinema | - | false |
| - | Manifesto | - | - | - | - | - | - | 2 | Cannon Film Distributors | - | false |
