| TW | LW | Total | %± LW | Share | Releases | #1 Release
| Gross | % of Total | Week | Distributor
| New This Week
|
|---|
| 1 | 1 | $30,498,210 | -32.5% | 19.9% | 5 | Marley & Me | $24,263,763 | 79.6% | 2 | Twentieth Century Fox | - |
| 2 | 2 | $24,375,156 | -22.3% | 15.9% | 6 | Bedtime Stories | $20,501,339 | 84.1% | 2 | Walt Disney Studios Motion Pictures | - |
| 3 | 4 | $19,964,586 | -17.6% | 13% | 9 | Yes Man | $13,910,477 | 69.7% | 3 | Warner Bros. | - |
| 4 | 3 | $18,691,248 | -30.4% | 12.2% | 1 | The Curious Case of Benjamin Button | $18,691,248 | 100% | 2 | Paramount Pictures | - |
| 5 | 5 | $14,094,617 | -33% | 9.2% | 1 | Valkyrie | $14,094,617 | 100% | 2 | United Artists | - |
| 6 | 6 | $11,404,428 | -23.3% | 7.4% | 3 | Seven Pounds | $10,068,518 | 88.3% | 3 | Sony Pictures Releasing | - |
| 7 | 7 | $8,666,869 | -18% | 5.7% | 4 | The Tale of Despereaux | $6,939,295 | 80.1% | 3 | Universal Pictures | - |
| 8 | 11 | $5,190,628 | +9.5% | 3.4% | 3 | Slumdog Millionaire | $4,690,769 | 90.4% | 8 | - | - |
| 9 | 9 | $5,166,967 | -5.5% | 3.4% | 3 | Doubt | $5,000,893 | 96.8% | 4 | Miramax | - |
| 10 | 10 | $4,681,804 | -2.2% | 3.1% | 2 | Twilight | $4,648,642 | 99.3% | 7 | Summit Entertainment | - |
| 11 | 8 | $3,259,898 | -50.5% | 2.1% | 1 | The Spirit | $3,259,898 | 100% | 2 | Lionsgate Films | - |
| 12 | 12 | $1,888,510 | +7.1% | 1.2% | 1 | Milk | $1,888,510 | 100% | 6 | Focus Features | - |
| 13 | 15 | $1,665,989 | +142.6% | 1.1% | 2 | The Reader | $1,598,472 | 95.9% | 4 | The Weinstein Company | - |
| 14 | 18 | $1,109,474 | +484.2% | 0.7% | 2 | Revolutionary Road | $985,961 | 88.9% | 2 | Paramount Vantage | - |
| 15 | 13 | $1,105,001 | +2.2% | 0.7% | 2 | Madagascar: Escape 2 Africa | $958,397 | 86.7% | 9 | DreamWorks | - |
| 16 | 17 | $354,770 | +16.1% | 0.2% | 5 | Rachel Getting Married | $166,733 | 47% | 14 | Sony Pictures Classics | - |
| 17 | 14 | $288,075 | -62.4% | 0.2% | 1 | Ghajini | $288,075 | 100% | 2 | Adlabs Films | - |
| 18 | 16 | $258,173 | -37.2% | 0.2% | 2 | Nothing Like the Holidays | $155,967 | 60.4% | 4 | Overture Films | - |
| 19 | 19 | $108,178 | -35.6% | <0.1% | 3 | Magnificent Desolation: Walking on the Moon | $48,722 | 45% | 172 | IMAX | - |
| 20 | 22 | $104,716 | +82.6% | <0.1% | 3 | Let the Right One In | $92,012 | 87.9% | 11 | Magnolia Pictures | - |
| 21 | 21 | $86,104 | -20.2% | <0.1% | 3 | A Christmas Tale | $40,756 | 47.3% | 8 | IFC Films | - |
| 22 | 23 | $77,488 | +52% | <0.1% | 2 | Sea Monsters: A Prehistoric Adventure | $66,662 | 86% | 66 | National Geographic Entertainment | - |
| 23 | 20 | $72,537 | -53.8% | <0.1% | 1 | Rab Ne Bana Di Jodi | $72,537 | 100% | 4 | Yash Raj Films | - |
| 24 | 24 | $56,806 | +18.2% | <0.1% | 1 | Fireproof | $56,806 | 100% | 15 | The Samuel Goldwyn Company | - |
| 25 | 25 | $43,084 | +10.6% | <0.1% | 2 | Vicky Cristina Barcelona | $40,424 | 93.8% | 21 | - | - |
| 26 | 29 | $39,523 | +260.5% | <0.1% | 1 | Igor | $39,523 | 100% | 16 | Metro-Goldwyn-Mayer (MGM) | - |
| 27 | 28 | $24,938 | +107.7% | <0.1% | 1 | Wendy and Lucy | $24,938 | 100% | 4 | Oscilloscope | - |
| 28 | 26 | $24,373 | +20.9% | <0.1% | 1 | Dolphins and Whales 3D: Tribes of the Ocean | $24,373 | 100% | 47 | 3D Entertainment | - |
| 29 | 27 | $18,059 | +4.1% | <0.1% | 1 | The Haunting of Molly Hartley | $18,059 | 100% | 10 | Freestyle Releasing | - |
| 32 | 31 | $9,126 | +37.7% | <0.1% | 1 | JCVD | $9,126 | 100% | 9 | - | - |
| 33 | 32 | $7,538 | +32.1% | <0.1% | 1 | Tell No One | $7,538 | 100% | 27 | Music Box Films | - |
| 34 | 30 | $7,248 | -8.6% | <0.1% | 2 | A Secret | $4,263 | 58.8% | 18 | Strand Releasing | - |
| 37 | 38 | $1,887 | +129.3% | <0.1% | 1 | Stranded | $1,887 | 100% | 11 | Zeitgeist Films | - |
| 38 | 34 | $1,632 | +0.9% | <0.1% | 1 | Were the World Mine | $1,632 | 100% | 10 | - | - |
| 40 | 36 | $788 | -50.3% | <0.1% | 1 | Lola Montès | $788 | 100% | 13 | Rialto Pictures | - |
| 42 | 37 | $644 | -34% | <0.1% | 1 | The Secrets | $644 | 100% | 6 | Monterey Media | - |
