| TW | LW | Total | %± LW | Share | Releases | #1 Release
| Gross | % of Total | Week | Distributor
| New This Week
|
|---|
| 1 | 3 | $45,156,568 | +273.3% | 22.4% | 5 | Marley & Me | $36,357,586 | 80.5% | 1 | Twentieth Century Fox | - |
| 2 | 6 | $31,373,720 | +605.9% | 15.6% | 6 | Bedtime Stories | $27,450,296 | 87.5% | 1 | Walt Disney Studios Motion Pictures | - |
| 4 | 1 | $24,232,675 | -9.7% | 12% | 9 | Yes Man | $16,657,046 | 68.7% | 2 | Warner Bros. | - |
| 6 | 2 | $14,874,075 | -15.1% | 7.4% | 3 | Seven Pounds | $13,203,236 | 88.8% | 2 | Sony Pictures Releasing | - |
| 7 | 4 | $10,564,906 | -5.9% | 5.2% | 4 | The Tale of Despereaux | $8,932,625 | 84.5% | 2 | Universal Pictures | - |
| 8 | 12 | $6,592,208 | +652.5% | 3.3% | 2 | The Spirit | $6,463,278 | 98% | 1 | Lionsgate Films | - |
| 9 | 11 | $5,469,513 | +446.9% | 2.7% | 3 | Doubt | $5,339,742 | 97.6% | 3 | Miramax | - |
| 10 | 5 | $4,786,488 | -7.9% | 2.4% | 2 | Twilight | $4,742,432 | 99.1% | 6 | Summit Entertainment | - |
| 11 | 7 | $4,739,262 | +43.4% | 2.4% | 3 | Slumdog Millionaire | $4,301,870 | 90.8% | 7 | - | - |
| 12 | 8 | $1,762,638 | +1% | 0.9% | 1 | Milk | $1,762,638 | 100% | 5 | Focus Features | - |
| 13 | 9 | $1,081,620 | -36.3% | 0.5% | 2 | Madagascar: Escape 2 Africa | $923,018 | 85.3% | 8 | DreamWorks | - |
| 15 | 15 | $686,713 | +431.9% | 0.3% | 2 | The Reader | $664,013 | 96.7% | 3 | The Weinstein Company | - |
| 16 | 10 | $411,293 | -68.5% | 0.2% | 2 | Nothing Like the Holidays | $314,033 | 76.4% | 3 | Overture Films | - |
| 17 | 14 | $305,509 | +11.9% | 0.2% | 6 | Rachel Getting Married | $131,440 | 43% | 13 | Sony Pictures Classics | - |
| 19 | 17 | $167,893 | +96.5% | <0.1% | 3 | Magnificent Desolation: Walking on the Moon | $136,565 | 81.3% | 171 | IMAX | - |
| 20 | 13 | $156,871 | -52% | <0.1% | 1 | Rab Ne Bana Di Jodi | $156,871 | 100% | 3 | Yash Raj Films | - |
| 21 | 19 | $107,947 | +77.4% | <0.1% | 3 | A Christmas Tale | $63,594 | 58.9% | 7 | IFC Films | - |
| 22 | 18 | $57,336 | -30.4% | <0.1% | 3 | Let the Right One In | $51,477 | 89.8% | 10 | Magnolia Pictures | - |
| 23 | 21 | $50,974 | +54.5% | <0.1% | 2 | Sea Monsters: A Prehistoric Adventure | $41,872 | 82.1% | 65 | National Geographic Entertainment | - |
| 24 | 20 | $48,052 | -14.4% | <0.1% | 1 | Fireproof | $48,052 | 100% | 14 | The Samuel Goldwyn Company | - |
| 25 | 16 | $38,958 | -55.5% | <0.1% | 2 | Vicky Cristina Barcelona | $35,154 | 90.2% | 20 | - | - |
| 26 | 27 | $20,154 | +161.7% | <0.1% | 1 | Dolphins and Whales 3D: Tribes of the Ocean | $20,154 | 100% | 46 | 3D Entertainment | - |
| 27 | 22 | $17,342 | -30.5% | <0.1% | 1 | The Haunting of Molly Hartley | $17,342 | 100% | 9 | Freestyle Releasing | - |
| 28 | 24 | $12,004 | -25% | <0.1% | 1 | Wendy and Lucy | $12,004 | 100% | 3 | Oscilloscope | - |
| 29 | 23 | $10,964 | -40.4% | <0.1% | 1 | Igor | $10,964 | 100% | 15 | Metro-Goldwyn-Mayer (MGM) | - |
| 30 | 26 | $7,930 | +0.8% | <0.1% | 2 | A Secret | $6,357 | 80.2% | 17 | Strand Releasing | - |
| 31 | 25 | $6,626 | -50.1% | <0.1% | 1 | JCVD | $6,626 | 100% | 8 | - | - |
| 32 | 29 | $5,706 | +60.5% | <0.1% | 1 | Tell No One | $5,706 | 100% | 26 | Music Box Films | - |
| 34 | 30 | $1,618 | -48.7% | <0.1% | 1 | Were the World Mine | $1,618 | 100% | 9 | - | - |
| 35 | 33 | $1,588 | -32.8% | <0.1% | 2 | Monsieur Verdoux | $937 | 59% | 42 | The Film Desk | - |
| 37 | 31 | $976 | -67.9% | <0.1% | 1 | The Secrets | $976 | 100% | 5 | Monterey Media | - |
| 38 | 34 | $823 | +16.1% | <0.1% | 1 | Stranded | $823 | 100% | 10 | Zeitgeist Films | - |
| 39 | 37 | $657 | +17.3% | <0.1% | 1 | Moving Midway | $657 | 100% | 16 | First Run | - |
