| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | The Final Destination | $12,435,000 | $12,368,882 | -$66,118 | -0.5% | 3,121 | $47,566,000 | $47,508,879 | 2 | Warner Bros. | - |
| 2 | 3 | +1 | All About Steve | $11,200,000 | $11,241,214 | +$41,214 | +0.4% | 2,251 | $11,200,000 | $11,241,214 | 1 | Twentieth Century Fox | - |
| 3 | 2 | -1 | Inglourious Basterds | $10,847,000 | $11,629,394 | +$782,394 | +7.2% | 3,358 | $91,042,000 | $91,825,002 | 3 | The Weinstein Company | - |
| 4 | 4 | - | Gamer | $9,000,000 | $9,156,057 | +$156,057 | +1.7% | 2,502 | $9,000,000 | $9,156,057 | 1 | Lionsgate Films | - |
| 5 | 5 | - | District 9 | $7,000,000 | $7,076,937 | +$76,937 | +1.1% | 3,139 | $101,274,000 | $101,351,058 | 4 | TriStar Pictures | - |
| 6 | 6 | - | Halloween II | $5,608,000 | $5,745,206 | +$137,206 | +2.4% | 3,088 | $25,664,000 | $25,801,098 | 2 | - | - |
| 7 | 7 | - | Julie & Julia | $5,200,000 | $5,324,583 | +$124,583 | +2.4% | 2,528 | $78,840,000 | $78,964,977 | 5 | Sony Pictures Releasing | - |
| 8 | 8 | - | G.I. Joe: The Rise of Cobra | $5,100,000 | $5,175,113 | +$75,113 | +1.5% | 2,846 | $139,415,000 | $139,491,579 | 5 | Paramount Pictures | - |
| 9 | 10 | +1 | The Time Traveler's Wife | $4,215,000 | $4,326,787 | +$111,787 | +2.7% | 2,803 | $54,557,000 | $54,670,789 | 4 | Warner Bros. | - |
| 10 | 9 | -1 | Extract | $4,187,000 | $4,340,108 | +$153,108 | +3.7% | 1,611 | $4,187,000 | $4,340,108 | 1 | Miramax | - |
| 11 | 11 | - | Shorts | $2,605,000 | $2,734,938 | +$129,938 | +5% | 2,631 | $17,028,000 | $17,161,998 | 3 | Warner Bros. | - |
| 12 | 12 | - | G-Force | $1,977,000 | $1,999,582 | +$22,582 | +1.1% | 1,477 | $114,604,000 | $114,626,288 | 7 | Walt Disney Studios Motion Pictures | - |
| 13 | 14 | +1 | Harry Potter and the Half-Blood Prince | $1,815,000 | $1,828,140 | +$13,140 | +0.7% | 1,091 | $296,919,000 | $296,940,258 | 8 | Warner Bros. | - |
| 14 | 13 | -1 | 500 Days of Summer | $1,800,000 | $1,850,256 | +$50,256 | +2.8% | 935 | $27,868,000 | $27,918,434 | 8 | - | - |
| 15 | 15 | - | Taking Woodstock | $1,481,000 | $1,483,183 | +$2,183 | +0.1% | 1,395 | $6,007,000 | $6,008,843 | 2 | Focus Features | - |
| 16 | 16 | - | Ponyo | $1,288,000 | $1,308,412 | +$20,412 | +1.6% | 890 | $12,937,000 | $12,957,933 | 4 | Walt Disney Studios Motion Pictures | - |
| 17 | 17 | - | The Hangover | $1,160,000 | $1,222,045 | +$62,045 | +5.3% | 709 | $271,857,000 | $271,921,527 | 14 | Warner Bros. | - |
| 18 | 18 | - | The Ugly Truth | $875,000 | $911,965 | +$36,965 | +4.2% | 773 | $87,319,000 | $87,356,103 | 7 | Sony Pictures Releasing | - |
| 19 | 19 | - | Transformers: Revenge of the Fallen | $805,000 | $803,663 | -$1,337 | -0.2% | 507 | $400,437,000 | $400,434,854 | 11 | DreamWorks | - |
| 20 | 20 | - | Up | $745,000 | $730,953 | -$14,047 | -1.9% | 418 | $290,645,000 | $290,631,082 | 15 | Walt Disney Studios Motion Pictures | - |
| 21 | 21 | - | Ice Age: Dawn of the Dinosaurs | $600,000 | $615,146 | +$15,146 | +2.5% | 425 | $194,022,000 | $194,036,834 | 10 | Twentieth Century Fox | - |
| 22 | 22 | - | The Proposal | $583,000 | $597,740 | +$14,740 | +2.5% | 441 | $160,964,000 | $160,978,788 | 12 | Walt Disney Studios Motion Pictures | - |
| 23 | 23 | - | Aliens in the Attic | $484,000 | $524,486 | +$40,486 | +8.4% | 522 | $23,584,000 | $23,624,199 | 6 | Twentieth Century Fox | - |
| 24 | 24 | - | My One and Only | $386,000 | $385,373 | -$627 | -0.2% | 77 | $585,000 | $584,473 | 3 | Freestyle Releasing | - |
| 25 | 25 | - | The Goods: Live Hard, Sell Hard | $330,000 | $353,702 | +$23,702 | +7.2% | 508 | $14,713,000 | $14,736,850 | 4 | Paramount Vantage | - |
| 26 | 26 | - | Star Trek | $305,000 | $329,668 | +$24,668 | +8.1% | 268 | $257,069,000 | $257,094,634 | 18 | Paramount Pictures | - |
| 27 | 27 | - | Post Grad | $300,000 | $298,944 | -$1,056 | -0.4% | 673 | $6,137,000 | $6,135,610 | 3 | Twentieth Century Fox | - |
| 28 | 30 | +2 | Adam | $245,000 | $240,223 | -$4,777 | -1.9% | 159 | $1,745,000 | $1,739,959 | 6 | - | - |
| 29 | 32 | +3 | Night at the Museum: Battle of the Smithsonian | $203,000 | $193,149 | -$9,851 | -4.9% | 205 | $176,743,000 | $176,732,888 | 16 | Twentieth Century Fox | - |
| 30 | 34 | +4 | A Perfect Getaway | $168,000 | $182,490 | +$14,490 | +8.6% | 237 | $15,303,000 | $15,317,205 | 5 | Universal Pictures | - |
| 31 | 35 | +4 | Funny People | $160,000 | $170,095 | +$10,095 | +6.3% | 252 | $51,627,000 | $51,636,960 | 6 | Universal Pictures | - |
| 32 | 36 | +4 | It Might Get Loud | $160,000 | $158,224 | -$1,776 | -1.1% | 56 | $570,000 | $568,294 | 4 | Sony Pictures Classics | - |
| 33 | 38 | +5 | The September Issue | $147,000 | $146,002 | -$998 | -0.7% | 20 | $473,000 | $472,219 | 2 | Roadside Attractions | - |
| 34 | 43 | +9 | Amreeka | $50,000 | $58,823 | +$8,823 | +17.6% | 4 | $50,000 | $58,823 | 1 | National Geographic Entertainment | - |
| 35 | 53 | +18 | The Cove | $32,500 | $31,894 | -$606 | -1.9% | 24 | $669,000 | $677,840 | 6 | Roadside Attractions | - |
| 36 | 67 | +31 | Tetro | $10,300 | $13,627 | +$3,327 | +32.3% | 12 | $471,000 | $474,002 | 13 | American Zoetrope | - |
| 37 | 77 | +40 | Unmistaken Child | $5,250 | $5,384 | +$134 | +2.6% | 4 | $231,000 | $230,854 | 14 | Oscilloscope | - |
| 38 | 87 | +49 | Herb & Dorothy | $2,000 | $2,275 | +$275 | +13.8% | 3 | $179,000 | $179,506 | 14 | Arthouse Films | - |
| 39 | 97 | +58 | Treeless Mountain | $1,120 | $1,106 | -$14 | -1.2% | 1 | $58,900 | $58,880 | 20 | Oscilloscope | - |
