| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Transformers | $67,600,000 | $70,502,384 | +$2,902,384 | +4.3% | 4,011 | $152,500,000 | $155,405,412 | 1 | DreamWorks | - |
| 2 | 2 | - | Ratatouille | $29,029,000 | $29,014,293 | -$14,707 | <0.1% | 3,940 | $109,546,000 | $109,531,598 | 2 | Walt Disney Studios Motion Pictures | - |
| 3 | 3 | - | Live Free or Die Hard | $17,400,000 | $17,730,149 | +$330,149 | +1.9% | 3,411 | $84,160,000 | $84,424,123 | 2 | Twentieth Century Fox | - |
| 4 | 4 | - | License to Wed | $10,400,000 | $10,422,258 | +$22,258 | +0.2% | 2,604 | $17,816,000 | $17,838,076 | 1 | Warner Bros. | - |
| 5 | 5 | - | Evan Almighty | $8,114,000 | $8,719,135 | +$605,135 | +7.5% | 3,460 | $78,101,000 | $78,706,785 | 3 | Universal Pictures | - |
| 6 | 6 | - | 1408 | $7,140,000 | $7,088,979 | -$51,021 | -0.7% | 2,631 | $53,789,000 | $53,738,325 | 3 | - | - |
| 7 | 7 | - | Knocked Up | $5,159,000 | $5,222,680 | +$63,680 | +1.2% | 2,213 | $132,026,000 | $132,089,425 | 6 | Universal Pictures | - |
| 8 | 8 | - | Fantastic Four: Rise of the Silver Surfer | $4,150,000 | $4,239,993 | +$89,993 | +2.2% | 2,618 | $123,791,000 | $123,881,586 | 4 | Twentieth Century Fox | - |
| 9 | 9 | - | Sicko | $3,650,000 | $3,600,179 | -$49,821 | -1.4% | 702 | $11,502,000 | $11,452,560 | 3 | Lionsgate Films | - |
| 10 | 10 | - | Ocean's Thirteen | $3,525,000 | $3,525,366 | +$366 | <0.1% | 2,102 | $109,145,000 | $109,145,316 | 5 | Warner Bros. | - |
| 11 | 11 | - | Pirates of the Caribbean: At World's End | $3,025,000 | $3,008,962 | -$16,038 | -0.5% | 1,869 | $301,741,000 | $301,725,691 | 7 | Walt Disney Studios Motion Pictures | - |
| 12 | 12 | - | Evening | $2,337,000 | - | - | - | 979 | $8,340,000 | - | 2 | Focus Features | - |
| 13 | 13 | - | Shrek the Third | $1,395,000 | $1,537,841 | +$142,841 | +10.2% | 1,421 | $316,597,000 | $316,740,255 | 8 | DreamWorks | - |
| 14 | 14 | - | Surf's Up | $950,000 | $991,175 | +$41,175 | +4.3% | 1,458 | $56,001,000 | $56,042,318 | 5 | Sony Pictures Releasing | - |
| 15 | 16 | +1 | A Mighty Heart | $640,000 | $647,288 | +$7,288 | +1.1% | 651 | $8,397,000 | $8,404,897 | 3 | Paramount Vantage | - |
| 16 | 17 | +1 | La Vie En Rose | $614,000 | $608,884 | -$5,116 | -0.8% | 162 | $6,036,000 | $6,030,711 | 5 | Picturehouse | - |
| 17 | 18 | +1 | Once | $425,000 | $439,648 | +$14,648 | +3.4% | 132 | $4,550,000 | $4,563,755 | 8 | - | - |
| 18 | 19 | +1 | Waitress | $375,000 | $387,020 | +$12,020 | +3.2% | 227 | $17,449,000 | $17,447,571 | 10 | - | - |
| 19 | 20 | +1 | Spider-Man 3 | $350,000 | $303,553 | -$46,447 | -13.3% | 310 | $334,391,000 | $334,344,283 | 10 | Sony Pictures Releasing | - |
| 20 | 22 | +2 | You Kill Me | $259,000 | - | - | - | 63 | $842,000 | - | 3 | IFC Films | - |
| 21 | 24 | +3 | Paris, I Love You | $206,000 | - | - | - | 103 | $4,176,000 | - | 10 | First Look International | - |
| 22 | 28 | +6 | Rescue Dawn | $104,000 | $110,326 | +$6,326 | +6.1% | 6 | $162,000 | $167,872 | 1 | Metro-Goldwyn-Mayer (MGM) | - |
| 23 | 32 | +9 | Hot Fuzz | $63,800 | $68,566 | +$4,766 | +7.5% | 140 | $23,468,000 | $23,472,882 | 12 | Rogue Pictures | - |
| 24 | 35 | +11 | Joshua | $51,100 | $51,233 | +$133 | +0.3% | 6 | $51,100 | $51,233 | 1 | - | - |
| 25 | 42 | +17 | The Lives of Others | $48,400 | $33,172 | -$15,228 | -31.5% | 25 | $10,830,000 | $10,814,343 | 22 | Sony Pictures Classics | - |
| 26 | 39 | +13 | Paprika | $44,100 | $40,519 | -$3,581 | -8.1% | 33 | $646,000 | $642,641 | 7 | Sony Pictures Classics | - |
| 27 | 43 | +16 | Black Book | $32,100 | $31,585 | -$515 | -1.6% | 30 | $4,297,000 | $4,296,532 | 14 | Sony Pictures Classics | - |
| 28 | 47 | +19 | Away from Her | $21,700 | $23,576 | +$1,876 | +8.6% | 38 | $4,499,000 | $4,501,383 | 10 | Lionsgate Films | - |
| 29 | 53 | +24 | The Valet | $19,100 | $14,903 | -$4,197 | -22% | 21 | $1,856,000 | $1,851,432 | 12 | Sony Pictures Classics | - |
| 30 | 51 | +21 | Vitus | $16,300 | $15,906 | -$394 | -2.4% | 7 | $28,500 | $28,098 | 2 | Sony Pictures Classics | - |
| 31 | 59 | +28 | Fido | $10,100 | $10,343 | +$243 | +2.4% | 4 | $298,000 | $298,110 | 4 | Roadside Attractions | - |
| 32 | 65 | +33 | Colma: The Musical | $7,100 | $7,014 | -$86 | -1.2% | 2 | $28,100 | $28,066 | 3 | Roadside Attractions | - |
| 33 | 70 | +37 | Ghosts of Cité Soleil | $4,500 | $4,433 | -$67 | -1.5% | 1 | $18,100 | $20,617 | 2 | THINKFilm | - |
