| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Scary Movie 4 | $41,020,000 | $40,222,875 | -$797,125 | -1.9% | 3,602 | $41,020,000 | $40,222,875 | 1 | - | - |
| 2 | 2 | - | Ice Age: The Meltdown | $20,000,000 | $20,026,625 | +$26,625 | +0.1% | 3,873 | $147,188,000 | $147,226,916 | 3 | Twentieth Century Fox | - |
| 3 | 3 | - | The Benchwarmers | $10,000,000 | $9,913,291 | -$86,709 | -0.9% | 3,282 | $35,980,000 | $35,881,922 | 2 | Revolution Studios | - |
| 4 | 4 | - | The Wild | $9,559,000 | $9,684,809 | +$125,809 | +1.3% | 2,854 | $9,559,000 | $9,684,809 | 1 | Walt Disney Studios Motion Pictures | - |
| 5 | 5 | - | Take the Lead | $6,700,000 | - | - | - | 3,009 | $22,517,000 | - | 2 | New Line Cinema | - |
| 6 | 6 | - | Inside Man | $6,292,000 | $6,427,815 | +$135,815 | +2.2% | 2,477 | $75,285,000 | $75,421,180 | 4 | Universal Pictures | - |
| 7 | 7 | - | Lucky Number Slevin | $4,600,000 | $4,752,800 | +$152,800 | +3.3% | 1,989 | $14,140,000 | $14,297,147 | 2 | - | - |
| 8 | 8 | - | Thank You for Smoking | $4,450,000 | $4,491,102 | +$41,102 | +0.9% | 1,015 | $11,498,000 | $11,539,571 | 5 | - | - |
| 9 | 9 | - | Failure to Launch | $2,599,000 | $2,608,433 | +$9,433 | +0.4% | 1,950 | $83,171,000 | $83,179,669 | 6 | Paramount Pictures | - |
| 10 | 10 | - | V for Vendetta | $2,170,000 | $2,224,266 | +$54,266 | +2.5% | 1,380 | $65,991,000 | $66,037,682 | 5 | Warner Bros. | - |
| 11 | 11 | - | ATL | $1,345,000 | $1,415,291 | +$70,291 | +5.2% | 1,315 | $19,653,000 | $19,724,950 | 3 | Warner Bros. | - |
| 12 | 12 | - | Phat Girlz | $1,250,000 | $1,340,864 | +$90,864 | +7.3% | 1,060 | $5,248,000 | $5,337,603 | 2 | - | - |
| 13 | 13 | - | My Brother's Wife | $1,025,000 | $1,018,750 | -$6,250 | -0.6% | 206 | $1,025,000 | $1,018,750 | 1 | Lionsgate Films | - |
| 14 | 14 | - | She's the Man | $923,000 | $930,016 | +$7,016 | +0.8% | 1,051 | $31,777,000 | $31,784,552 | 5 | DreamWorks | - |
| 15 | 15 | - | Friends with Money | $805,000 | - | - | - | 42 | $1,600,000 | - | 2 | Sony Pictures Classics | - |
| 16 | 16 | - | Stay Alive | $681,000 | $726,689 | +$45,689 | +6.7% | 1,039 | $22,031,000 | $22,076,589 | 4 | Walt Disney Studios Motion Pictures | - |
| 17 | 17 | - | Larry the Cable Guy: Health Inspector | $540,000 | $672,986 | +$132,986 | +24.6% | 976 | $14,634,000 | $14,766,968 | 4 | Lionsgate Films | - |
| 18 | 19 | +1 | The Shaggy Dog | $338,000 | $373,281 | +$35,281 | +10.4% | 748 | $56,675,000 | $56,709,956 | 6 | Walt Disney Studios Motion Pictures | - |
| 19 | 22 | +3 | Brick | $233,000 | - | - | - | 45 | $634,000 | - | 3 | Focus Features | - |
| 20 | 24 | +4 | Preaching to the Choir | $221,000 | - | - | - | 143 | $221,000 | - | 1 | Freestyle Releasing | - |
| 21 | 25 | +4 | Tsotsi | $208,000 | $207,903 | -$97 | <0.1% | 118 | $2,286,000 | $2,286,496 | 8 | Miramax | - |
| 22 | 31 | +9 | The Notorious Bettie Page | $145,000 | $143,131 | -$1,869 | -1.3% | 20 | $145,000 | $143,131 | 1 | Picturehouse | - |
| 23 | 39 | +16 | When Do We Eat? | $102,000 | $104,338 | +$2,338 | +2.3% | 41 | $279,000 | $281,583 | 2 | THINKFilm | - |
| 24 | 43 | +19 | Kinky Boots | $81,100 | $77,529 | -$3,571 | -4.4% | 9 | $81,100 | $77,529 | 1 | Miramax | - |
| 25 | 40 | +15 | Hoodwinked! | $80,000 | $101,225 | +$21,225 | +26.5% | 201 | $51,143,000 | $51,164,583 | 18 | The Weinstein Company | - |
| 26 | 37 | +11 | Final Destination 3 | $76,000 | $105,940 | +$29,940 | +39.4% | 135 | $54,068,000 | $54,098,051 | 10 | New Line Cinema | - |
| 27 | 47 | +20 | On a Clear Day | $67,200 | $67,246 | +$46 | <0.1% | 33 | $90,700 | $90,663 | 2 | Focus Features | - |
| 28 | 48 | +20 | Hard Candy | $60,000 | $58,049 | -$1,951 | -3.3% | 2 | $60,000 | $58,049 | 1 | Lionsgate Films | - |
| 29 | 51 | +22 | Mrs. Henderson Presents | $49,000 | $53,076 | +$4,076 | +8.3% | 74 | $10,838,000 | $10,842,360 | 19 | The Weinstein Company | - |
| 30 | 56 | +26 | Madea's Family Reunion | $39,000 | $40,061 | +$1,061 | +2.7% | 73 | $63,126,000 | $63,126,718 | 8 | Lionsgate Films | - |
| 31 | 69 | +38 | C.S.A.: The Confederate States of America | $33,800 | $25,351 | -$8,449 | -25% | 21 | $546,000 | $537,108 | 28 | IFC Films | - |
| 32 | 60 | +28 | Transamerica | $30,100 | $33,482 | +$3,382 | +11.2% | 44 | $8,826,000 | $8,829,823 | 20 | The Weinstein Company | - |
| 33 | 66 | +33 | Brokeback Mountain | $29,000 | $30,396 | +$1,396 | +4.8% | 65 | $83,025,000 | $83,025,853 | 19 | Focus Features | - |
| 34 | 71 | +37 | Mozart and the Whale | $21,500 | $19,610 | -$1,890 | -8.8% | 5 | $21,500 | $19,610 | 1 | - | - |
| 35 | 70 | +35 | Doogal | $20,800 | - | - | - | - | $7,438,000 | - | 8 | The Weinstein Company | - |
| 36 | 72 | +36 | I Am a Sex Addict | $20,700 | $19,078 | -$1,622 | -7.8% | 5 | $43,600 | $41,880 | 2 | IFC Films | - |
| 37 | 80 | +43 | Drawing Restraint 9 | $15,900 | $13,615 | -$2,285 | -14.4% | 2 | $100,000 | $97,721 | 3 | IFC Films | - |
| 38 | 111 | +73 | Find Me Guilty | $3,700 | $3,172 | -$528 | -14.3% | 7 | $1,171,000 | $1,170,870 | 5 | Yari Film Group Releasing | - |
| 39 | 105 | +66 | Steve Harvey: Don't Trip... He Ain't Through with Me Yet | $3,300 | $3,635 | +$335 | +10.2% | 3 | $317,000 | $317,113 | 5 | Freestyle Releasing | - |
| 40 | 115 | +75 | Winter Passing | $2,700 | $2,260 | -$440 | -16.3% | 3 | $195,000 | $104,548 | 9 | Yari Film Group Releasing | - |
