| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Spider-Man: No Way Home | $1,701,090 | -39.2% | 402 | -25 | $4,231 | $22,798,352 | 3 | Sony Pictures Releasing | false | false |
| 2 | 2 | Sing 2 | $854,315 | -6.5% | 369 | +12 | $2,315 | $4,019,062 | 2 | Universal Pictures International (UPI) | false | false |
| 3 | 3 | The Matrix Resurrections | $374,993 | -51.7% | 359 | +14 | $1,044 | $2,485,084 | 2 | Warner Bros. | false | false |
| 4 | 4 | You Keep the Kids | $350,900 | -18.4% | 359 | +9 | $977 | $2,063,301 | 3 | Warner Bros. | false | false |
| 5 | - | The King's Man | $342,963 | - | 330 | - | $1,039 | $555,362 | 1 | Walt Disney Studios Motion Pictures | true | false |
| 6 | 5 | West Side Story | $187,902 | -37.3% | 342 | -15 | $549 | $888,445 | 2 | Walt Disney Studios Motion Pictures | false | false |
| 7 | 6 | Encanto | $119,477 | -33.5% | 280 | -28 | $426 | $7,202,419 | 6 | Walt Disney Studios Motion Pictures | false | false |
| 8 | - | The Card Counter | $113,788 | - | 152 | - | $748 | $166,704 | 1 | Universal Pictures International (UPI) | true | false |
| 9 | 8 | The Vault | $74,150 | -31.2% | 144 | -28 | $514 | $6,400,827 | 6 | Sony Pictures Releasing | false | false |
| 10 | 7 | House of Gucci | $71,517 | -35.7% | 132 | -47 | $541 | $3,775,206 | 6 | Universal Pictures International (UPI) | false | false |
| 11 | 28 | Ghostbusters: Afterlife | $47,447 | +6,201.1% | 167 | -77 | $284 | $3,603,718 | 5 | Sony Pictures Releasing | false | false |
| 12 | 10 | The Good Boss | $35,735 | -20.6% | 67 | -6 | $533 | $3,794,941 | 12 | Miramax | false | false |
| 13 | - | 100 Days with Tata | $23,993 | - | 136 | - | $176 | $38,995 | - | BTeam Pictures | - | false |
| 14 | - | Un tour chez ma fille | $17,164 | - | 74 | - | $231 | $25,756 | 1 | A Contracorriente Films | true | false |
| 15 | 11 | The Perfect Family | $6,949 | -60.7% | 51 | -33 | $136 | $1,489,758 | 3 | Universal Pictures International (UPI) | false | false |
| 16 | - | Baghdad in My Shadow | $5,860 | - | 18 | - | $325 | $8,673 | 1 | Surtsey Films | true | false |
| 17 | 12 | Silent Night | $5,545 | -66.4% | 35 | -13 | $158 | $39,135 | 2 | Vértice 360 | false | false |
| 18 | 13 | Love Gets a Room | $4,872 | -43.5% | 20 | -18 | $243 | $336,473 | 5 | A Contracorriente Films | false | false |
| 19 | 16 | A Bookshop in Paris | $4,465 | -24.3% | 18 | -13 | $248 | $42,778 | 3 | Adso Films | false | false |
| 20 | 15 | Tengamos la fiesta en paz | $4,245 | -44.9% | 19 | -10 | $223 | $340,288 | 5 | Infinito mas uno | false | false |
| 21 | 30 | The Odd-Job Men | $3,162 | +613.8% | 8 | -6 | $395 | $111,127 | 5 | Filmax | false | false |
| 22 | 20 | Lemon and Poppy Seed Cake | $2,816 | -19.1% | 9 | -7 | $312 | $674,139 | 8 | Filmax | false | false |
| 23 | 19 | Three Floors | $2,180 | -48.8% | 7 | -7 | $311 | $76,290 | 4 | Vértigo Films | false | false |
| 24 | 23 | Parallel Mothers | $2,038 | -8.7% | 8 | -1 | $254 | $2,934,670 | 13 | Sony Pictures Releasing | false | false |
| 25 | 24 | Maixabel | $2,000 | +10.4% | 3 | -1 | $666 | $3,216,668 | 15 | Walt Disney Pictures | false | false |
| 26 | 18 | That Was Life | $1,857 | -57.4% | 7 | -9 | $265 | $60,408 | 4 | - | false | false |
| 27 | 26 | The French Dispatch | $1,408 | -10.1% | - | - | - | $1,105,947 | 11 | Walt Disney Studios Motion Pictures | false | false |
| 28 | 21 | Eternals | $1,210 | -56.4% | - | - | - | $8,584,512 | 9 | Walt Disney Studios Motion Pictures | false | false |
| 29 | 25 | Wetland | $1,075 | -37.5% | 5 | -10 | $215 | $141,424 | 3 | Vértice 360 | false | false |
| 30 | 22 | The Daughter | $681 | -71.2% | 4 | -5 | $170 | $265,299 | 6 | Caramel Films | false | false |
| 31 | 29 | Valentina | $502 | -18.9% | 10 | - | $50 | $21,740 | 4 | Super 8 | false | false |
| 32 | 39 | The Sacred Spirit | $381 | +193.1% | 1 | - | $381 | $27,166 | 6 | - | false | false |
| 33 | 34 | Ron's Gone Wrong | $342 | +58.3% | - | - | - | $1,819,382 | 11 | Walt Disney Studios Motion Pictures | false | false |
| 34 | - | Spencer | $318 | - | 3 | - | $106 | $406,929 | 7 | Diamond Films | false | false |
| 35 | 38 | Who's Stopping Us | $217 | +34.8% | 1 | - | $217 | $18,798 | 10 | Atalanta Filmes | false | false |
| 36 | 31 | Alegría | $161 | -58.4% | 2 | -3 | $80 | $20,271 | 4 | Caramel Films | false | false |
| 37 | 37 | El refugio | $159 | -1.2% | 2 | -1 | $79 | $205,014 | 6 | Filmax | false | false |
| 38 | - | Mironins | $72 | - | 1 | - | $72 | $2,543 | 5 | - | false | false |
| 39 | - | The Belly of the Sea | $61 | - | 1 | - | $61 | $13,373 | 8 | Elastica | false | false |
| 40 | - | The Courier | $54 | - | 1 | - | $54 | $586,860 | 10 | Diamond Films | false | false |
| 41 | 35 | Libertad | $41 | -77% | 1 | -1 | $41 | $80,126 | 7 | Avalon | false | false |
| 42 | - | The Day of the Beast 2021 Re-release | $15 | - | 1 | - | $15 | $9,984 | 12 | Con Un Pack Distribución | false | false |
| 43 | 36 | Josefina | $11 | -93.6% | 1 | - | $11 | $28,419 | 9 | Super 8 | false | false |
