| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | No Time to Die | $2,979,565 | - | 512 | - | $5,819 | $2,979,565 | 1 | Universal Pictures International (UPI) | true | false |
| 2 | 1 | Dune | $884,597 | -46.6% | 392 | -96 | $2,256 | $6,578,118 | 3 | Warner Bros. | false | false |
| 3 | 2 | Space Jam: A New Legacy | $808,608 | -42.4% | 411 | +21 | $1,967 | $2,559,313 | 2 | Universal Pictures International (UPI) | false | false |
| 4 | 3 | Three Floors | $491,186 | -33.6% | 383 | +46 | $1,282 | $1,485,603 | 2 | 01 Distribution | false | false |
| 5 | - | Respect | $163,629 | - | 208 | - | $786 | $163,629 | 1 | Paramount Pictures | true | false |
| 6 | 8 | The King of Laughter | $113,843 | -43.7% | 98 | -128 | $1,161 | $1,373,488 | 4 | 01 Distribution | false | false |
| 7 | 7 | Like a Cat on a Highway 2 | $108,457 | -46.9% | 97 | -95 | $1,118 | $3,497,044 | 6 | - | false | false |
| 8 | - | Bing e Le Storie Degli Animali | $73,289 | - | 180 | - | $407 | $73,289 | 1 | Nexo Digital | true | false |
| 9 | 9 | Around the World in 80 Days 2021 Re-release | $64,613 | -55.9% | 131 | -163 | $493 | - | 4 | BIM Distribuzione | false | false |
| 10 | 6 | Shang-Chi and the Legend of the Ten Rings | $55,735 | -77.2% | - | - | - | $4,511,513 | 5 | Walt Disney Studios Motion Pictures | false | false |
| 11 | - | Titane | $48,131 | - | 59 | - | $815 | $73,884 | 1 | - | true | false |
| 12 | 13 | Welcome at Esposito's | $43,030 | -19.6% | 22 | -8 | $1,955 | $123,340 | 2 | - | false | false |
| 13 | - | Quo Vadis, Aida? | $36,243 | - | 39 | - | $929 | $44,627 | 1 | - | true | false |
| 14 | 16 | Drive My Car | $29,198 | +3% | 24 | +5 | $1,216 | $70,003 | 2 | Tucker Film | false | false |
| 15 | 15 | The Hole | $23,431 | -19.4% | 24 | - | $976 | $68,534 | 2 | Lucky Red | false | false |
| 16 | 12 | Supernova | $22,055 | -63.3% | 30 | -73 | $735 | $270,195 | 3 | Lucky Red | false | false |
| 17 | - | Sulla giostra | $20,814 | - | 68 | - | $306 | $20,814 | 1 | BIM Distribuzione | true | false |
| 18 | 10 | Me contro te - Il mistero della scuola incantata | $19,340 | -74.4% | 28 | -121 | $690 | $5,879,431 | 7 | Warner Bros. | false | false |
| 19 | 5 | Escape Room: Tournament of Champions | $15,745 | -94.1% | 138 | - | $114 | $503,836 | 2 | Warner Bros. | false | false |
| 20 | 22 | Nomadland | $1,067 | +57.4% | - | - | - | $2,270,688 | 23 | Walt Disney Pictures | false | false |
| 21 | 23 | Jungle Cruise | $26 | -96.1% | - | - | - | $2,004,242 | 10 | Walt Disney Studios Motion Pictures | false | false |
