| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Black Widow | $1,939,420 | -21.8% | - | - | - | $19,104,858 | 3 | Walt Disney Studios Motion Pictures | false | false |
| 2 | 2 | Space Jam: A New Legacy | $1,920,863 | +2.3% | 633 | +30 | $3,034 | $4,967,885 | 2 | Warner Bros. | false | false |
| 3 | 4 | The Croods: A New Age | $1,204,624 | +25.6% | 649 | +47 | $1,856 | $2,824,294 | 2 | Universal Pictures | false | false |
| 4 | - | Old | $1,191,888 | - | 560 | - | $2,128 | $1,191,888 | 1 | Universal Pictures | true | false |
| 5 | 3 | The Forever Purge | $823,323 | -16.9% | 518 | +17 | $1,589 | $2,475,987 | 2 | Universal Pictures | false | false |
| 6 | 5 | F9: The Fast Saga | $600,954 | -2.2% | 474 | -63 | $1,267 | $20,531,012 | 5 | Universal Pictures | false | false |
| 7 | 6 | Escape Room: Tournament of Champions | $239,530 | -37.4% | 367 | -47 | $652 | $921,910 | 2 | Sony Pictures Releasing | false | false |
| 8 | 7 | Peter Rabbit 2: The Runaway | $219,086 | +78.8% | 468 | -6 | $468 | $25,962,446 | 10 | Sony Pictures Releasing | false | false |
| 9 | - | Off the Rails | $110,957 | - | 327 | - | $339 | $110,957 | 1 | Munro Films | true | false |
| 10 | 8 | In the Heights | $90,869 | -4.6% | 197 | -73 | $461 | $5,893,129 | 6 | Warner Bros. | false | false |
| 11 | 10 | Cruella | $88,193 | +25.7% | - | - | - | $12,899,860 | 9 | Walt Disney Studios Motion Pictures | false | false |
| 12 | 9 | Summer of Soul (...Or, When the Revolution Could Not Be Televised) | $63,312 | -26.5% | 78 | -53 | $811 | $230,359 | 2 | Walt Disney Studios Motion Pictures | false | false |
| 13 | 12 | Another Round | $55,738 | -5% | 95 | -32 | $586 | $890,623 | 4 | StudioCanal | false | false |
| 14 | 11 | The Conjuring: The Devil Made Me Do It | $55,350 | -18% | 151 | -41 | $366 | $12,880,132 | 9 | Warner Bros. | false | false |
| 15 | 13 | Hitman's Wife's Bodyguard | $51,556 | +8.3% | 121 | -56 | $426 | $5,126,002 | 6 | Lionsgate Films | false | false |
| 16 | 18 | Tom & Jerry | $41,585 | +220.6% | 270 | +42 | $154 | $1,530,943 | 15 | Warner Bros. | false | false |
| 17 | - | Riders of Justice | $32,463 | - | 58 | - | $559 | $32,463 | 1 | Vertigo Films | true | false |
| 18 | 17 | The Father | $18,519 | +37.9% | 84 | +14 | $220 | $2,763,674 | 7 | Lionsgate Films | false | false |
| 19 | - | The World to Come | $17,091 | - | 104 | - | $164 | $17,091 | 1 | Sony Pictures Releasing | true | false |
| 20 | 16 | Supernova | $12,729 | -14.4% | 51 | -21 | $249 | $984,675 | 5 | StudioCanal UK | false | false |
| 21 | 19 | Raya and the Last Dragon | $11,763 | +43.3% | - | - | - | $1,147,565 | 10 | Walt Disney Pictures | false | false |
| 22 | - | Night of the Kings | $8,408 | - | 19 | - | $442 | $8,408 | 1 | Altitude Film Entertainment | true | false |
| 23 | - | Girlfriends | $4,580 | - | 25 | - | $183 | $4,580 | 1 | Park Circus | true | false |
| 24 | 29 | Bing's Animal Stories | $3,840 | +190.9% | 83 | +35 | $46 | $46,110 | 4 | Vue Entertainment | false | false |
| 25 | 21 | Dream Horse | $2,643 | -30.1% | 13 | -9 | $203 | $968,012 | 8 | Warner Bros. | false | false |
| 26 | - | I Never Cry | $1,567 | - | 9 | - | $174 | $1,567 | 1 | Eureka Entertainment | true | false |
| 27 | - | My Beautiful Laundrette 2021 Re-release | $1,404 | - | 3 | - | $468 | $7,913 | 4 | Park Circus | false | false |
| 28 | - | Trainspotting 2021 Re-release | $1,288 | - | 11 | - | $117 | - | 4 | Park Circus | false | false |
| 29 | - | Here We Are | $1,187 | - | 5 | - | $237 | $1,187 | 1 | - | true | false |
| 30 | 28 | After Love | $1,085 | -20.2% | 3 | -2 | $361 | $156,755 | 8 | British Film Institute (BFI) | false | false |
| 31 | 26 | Ammonite | $1,024 | -25.3% | 3 | -1 | $341 | $255,251 | 10 | Lionsgate Films | false | false |
| 32 | 33 | In the Earth | $920 | -4% | 3 | -12 | $306 | $213,928 | 6 | Universal Pictures | false | false |
| 33 | - | Thomas & Friends: The Great Race 2021 Re-release | $896 | - | 14 | - | $64 | $22,340 | 8 | National Amusements | false | false |
| 34 | 41 | Akram Khan's Giselle | $788 | +165.3% | 1 | - | $788 | $166,879 | 6 | Trafalgar Releasing | false | false |
| 35 | 27 | The Reason I Jump | $693 | -49.3% | 3 | -2 | $231 | $94,092 | 6 | Picturehouse Entertainment | false | false |
| 36 | - | Three Billboards Outside Ebbing, Missouri 2021 Re-release | $682 | - | 1 | - | $682 | $68,306 | 1 | 20th Century Fox International | true | false |
| 37 | - | Phil Liggett: The Voice of Cycling | $626 | - | 1 | - | $626 | $626 | 1 | N/A | true | false |
| 38 | - | Poly Styrene: I Am a Cliché | $378 | - | 1 | - | $378 | $3,668 | 21 | Modern Films | false | false |
| 39 | 35 | Branagh Theatre Live: Romeo and Juliet 2021 Re-release | $331 | -59% | 1 | -2 | $331 | - | 2 | More2Screen | false | false |
| 40 | 37 | Last Man Standing 2021 Re-release | $227 | -61.9% | 2 | - | $113 | $33,657 | 4 | Periscoop Film | false | false |
| 41 | - | The Secret Garden | $210 | - | 1 | - | $210 | $1,020,014 | 40 | Altitude Film Entertainment | false | false |
| 42 | - | Sisters with Transistors | $142 | - | 1 | - | $142 | $5,241 | 14 | Modern Films | false | false |
| 43 | 40 | The Witches | $87 | -77.9% | 1 | -2 | $87 | $37,588 | 15 | Warner Bros. | false | false |
| 44 | 38 | Brassed Off 2021 Re-release | $84 | -81.7% | 1 | -4 | $84 | $6,778 | 4 | Park Circus | false | false |
| 45 | 45 | Lady Boss: The Jackie Collins Story | $15 | -92% | 1 | -2 | $15 | $20,242 | 4 | Modern Films | false | false |
