| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Space Jam: A New Legacy | $31,053,362 | - | 3,965 | - | $7,831 | $31,053,362 | 1 | Warner Bros. | true | false |
| 2 | 1 | Black Widow | $25,847,496 | -67.8% | 4,275 | +115 | $6,046 | $131,609,167 | 2 | Walt Disney Studios Motion Pictures | false | false |
| 3 | - | Escape Room: Tournament of Champions | $8,801,391 | - | 2,815 | - | $3,126 | $8,801,391 | 1 | Sony Pictures Releasing | true | false |
| 4 | 2 | F9: The Fast Saga | $7,673,715 | -32.9% | 3,368 | -281 | $2,278 | $154,892,670 | 4 | Universal Pictures | false | false |
| 5 | 3 | The Boss Baby 2: Family Business | $4,730,085 | -46.7% | 3,449 | -239 | $1,371 | $44,651,760 | 3 | Universal Pictures | false | false |
| 6 | 4 | The Forever Purge | $4,115,830 | -42.4% | 2,735 | -323 | $1,504 | $35,866,540 | 3 | Universal Pictures | false | false |
| 7 | 5 | A Quiet Place Part II | $2,238,015 | -29.1% | 1,995 | -364 | $1,121 | $154,965,885 | 8 | Paramount Pictures | false | false |
| 8 | - | Roadrunner: A Film About Anthony Bourdain | $1,988,795 | - | 927 | - | $2,145 | $1,988,795 | 1 | Focus Features | true | false |
| 9 | 6 | Cruella | $1,165,810 | -50.8% | 1,175 | -700 | $992 | $83,483,327 | 8 | Walt Disney Studios Motion Pictures | false | false |
| 10 | - | Pig | $970,935 | - | 552 | - | $1,758 | $970,935 | 1 | Neon | true | false |
| 11 | 7 | Hitman's Wife's Bodyguard | $766,474 | -53% | 1,034 | -870 | $741 | $36,664,605 | 5 | Lionsgate Films | false | false |
| 12 | 8 | Peter Rabbit 2: The Runaway | $613,490 | -51.4% | 1,117 | -841 | $549 | $39,305,809 | 6 | Sony Pictures Releasing | false | false |
| 13 | 11 | In the Heights | $372,297 | -39.2% | 418 | -370 | $890 | $29,090,815 | 6 | Warner Bros. | false | false |
| 14 | 9 | The Conjuring: The Devil Made Me Do It | $353,137 | -46.1% | 390 | -277 | $905 | $64,577,677 | 7 | Warner Bros. | false | false |
| 15 | 10 | Zola | $284,325 | -55.3% | 533 | -868 | $533 | $4,289,963 | 3 | A24 | false | false |
| 16 | 12 | Summer of Soul (...Or, When the Revolution Could Not Be Televised) | $180,985 | -52.1% | 275 | -477 | $658 | $1,872,351 | 4 | Searchlight Pictures | false | false |
| 17 | 14 | 12 Mighty Orphans | $88,166 | -35.4% | 140 | -45 | $629 | $3,326,335 | 6 | Sony Pictures Releasing | false | false |
| 18 | 13 | Spirit Untamed | $58,115 | -58.5% | 910 | -58 | $63 | $17,487,395 | 7 | Universal Pictures | false | false |
| 19 | 15 | Queen Bees | $53,754 | -26.9% | 123 | -40 | $437 | $1,778,910 | 6 | Gravitas Ventures | false | false |
| 20 | 18 | Demon Slayer: Kimetsu no Yaiba - The Movie: Mugen Train | $29,722 | -15% | 38 | -4 | $782 | $49,435,402 | 13 | FUNimation Entertainment | false | false |
| 21 | 20 | I Carry You with Me | $26,356 | -14.6% | 111 | +54 | $237 | $135,156 | 4 | Sony Pictures Classics | false | false |
| 22 | 22 | Summertime | $21,650 | +0.7% | 63 | +61 | $343 | $43,140 | 2 | Good Deed Entertainment | false | false |
| 23 | 17 | The Loneliest Whale: The Search for 52 | $18,903 | -54% | 71 | - | $266 | $83,201 | 2 | Bleecker Street Media | false | false |
| 24 | 19 | Raya and the Last Dragon | $15,291 | -54.5% | 41 | -14 | $372 | $54,620,871 | 20 | Walt Disney Studios Motion Pictures | false | false |
| 25 | 21 | Werewolves Within | $15,064 | -39.8% | 46 | -17 | $327 | $557,413 | 4 | IFC Films | false | false |
| 26 | 23 | Witnesses | $13,476 | -33% | 21 | -5 | $641 | $771,375 | 7 | Purdie Distribution | false | false |
| 27 | 24 | Dream Horse | $9,657 | -38.9% | 30 | -14 | $321 | $2,853,673 | 9 | Bleecker Street Media | false | false |
| 28 | - | Mama Weed | $8,891 | - | 20 | - | $444 | $8,891 | 1 | Music Box Films | true | false |
| 29 | 26 | The Truffle Hunters | $8,425 | -26.7% | 15 | -3 | $561 | $494,064 | 20 | Sony Pictures Classics | false | false |
| 30 | 25 | Wrath of Man | $8,112 | -34.8% | 45 | -5 | $180 | $27,454,233 | 11 | United Artists Releasing | false | false |
| 31 | 31 | The Swimming Pool 2021 Re-release | $6,542 | +71.6% | 4 | -4 | $1,635 | $127,330 | 10 | Rialto Distribution | false | false |
| 32 | 27 | The Red Circle 2021 Re-release | $5,586 | -6% | 5 | +1 | $1,117 | $45,987 | 4 | Rialto Pictures | false | false |
| 33 | 28 | Rita Moreno: Just a Girl Who Decided to Go for It | $4,541 | -22.2% | 16 | -7 | $283 | $257,983 | 5 | Roadside Attractions | false | false |
| 34 | 29 | Summer of 85 | $3,628 | -29% | 10 | -3 | $362 | $67,120 | 5 | Music Box Films | false | false |
| 35 | - | Can You Bring It: Bill T. Jones and D-Man in the Waters | $2,558 | - | 1 | - | $2,558 | $3,777 | 1 | Kino Lorber | true | false |
| 36 | - | Rock Paper Scissors | $2,222 | - | 2 | - | $1,111 | $2,222 | 1 | Indican Pictures | true | false |
| 37 | - | Casanova, Last Love | $2,126 | - | 6 | - | $354 | $3,090 | 1 | Cohen Media Group | true | false |
| 38 | 32 | The Dry | $2,012 | -44.5% | 5 | -2 | $402 | $361,719 | 9 | IFC Films | false | false |
| 39 | 36 | Undine | $1,680 | -19.3% | 4 | -3 | $420 | $76,522 | 7 | IFC Films | false | false |
| 40 | 34 | Shiva Baby | $1,037 | -51.9% | 3 | -1 | $345 | $154,787 | 16 | Utopia | false | false |
| 41 | 37 | A Soldier's Story 2: Return from the Dead | $297 | -82.8% | 1 | -1 | $297 | $21,341 | 4 | Indican Pictures | false | false |
| 42 | - | Truman & Tennessee: An Intimate Conversation | $280 | - | 3 | - | $93 | $53,724 | 5 | Kino Lorber | false | false |
| 43 | 38 | The Ladykillers 2021 Re-release | $203 | -81.4% | 1 | -2 | $203 | $18,705 | 7 | Rialto Pictures | false | false |
| 44 | 41 | The Perfect Candidate | $47 | -58.8% | 1 | - | $47 | $28,664 | 10 | Music Box Films | false | false |
