| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | F9: The Fast Saga | $23,008,860 | -67.2% | 4,203 | +24 | $5,474 | $116,112,820 | 2 | Universal Pictures | false | false |
| 2 | - | The Boss Baby 2: Family Business | $16,000,665 | - | 3,644 | - | $4,390 | $16,000,665 | 1 | Universal Pictures | true | false |
| 3 | - | The Forever Purge | $12,551,220 | - | 3,051 | - | $4,113 | $12,551,220 | 1 | Universal Pictures | true | false |
| 4 | 2 | A Quiet Place Part II | $4,101,048 | -33.8% | 2,826 | -298 | $1,451 | $144,312,707 | 6 | Paramount Pictures | false | false |
| 5 | 3 | Hitman's Wife's Bodyguard | $3,002,155 | -38.1% | 3,361 | - | $893 | $31,380,322 | 3 | Lionsgate Films | false | false |
| 6 | 5 | Cruella | $2,386,652 | -37.3% | 2,380 | -440 | $1,002 | $76,425,636 | 6 | Walt Disney Studios Motion Pictures | false | false |
| 7 | 4 | Peter Rabbit 2: The Runaway | $2,189,910 | -54.1% | 2,954 | -377 | $741 | $34,356,392 | 4 | Sony Pictures Releasing | false | false |
| 8 | 6 | The Conjuring: The Devil Made Me Do It | $1,260,000 | -57.9% | 1,716 | -952 | $734 | $62,195,663 | 5 | Warner Bros. | false | true |
| 9 | - | Zola | $1,200,013 | - | 1,468 | - | $817 | $1,997,265 | 1 | A24 | true | false |
| 10 | 7 | In the Heights | $1,185,000 | -46.9% | 1,405 | -998 | $843 | $26,797,024 | 4 | Warner Bros. | false | true |
| 11 | - | Summer of Soul (...Or, When the Revolution Could Not Be Televised) | $647,634 | - | 752 | +152 | $861 | $647,634 | 2 | Searchlight Pictures | false | false |
| 12 | 8 | Spirit Untamed | $353,690 | -67.3% | 1,296 | -477 | $272 | $16,910,245 | 5 | Universal Pictures | false | false |
| 13 | 9 | Nobody | $278,310 | -53.2% | 224 | +109 | $1,242 | $27,197,095 | 15 | Universal Pictures | false | false |
| 14 | 10 | 12 Mighty Orphans | $204,709 | -63.1% | 338 | -682 | $605 | $2,790,070 | 4 | Sony Pictures Releasing | false | false |
| 15 | 12 | The House Next Door: Meet the Blacks 2 | $86,559 | -62.9% | 116 | -219 | $746 | $2,768,443 | 4 | Hidden Empire Film Group (HEFG) | false | false |
| 16 | 11 | Werewolves Within | $86,100 | -65.7% | 209 | -61 | $411 | $443,917 | 2 | IFC Films | false | false |
| 17 | 15 | Queen Bees | $81,919 | -51% | 170 | -185 | $481 | $1,519,333 | 4 | Gravitas Ventures | false | false |
| 18 | 17 | Demon Slayer: Kimetsu no Yaiba - The Movie: Mugen Train | $58,568 | -50.4% | 81 | -64 | $723 | $49,276,871 | 11 | FUNimation Entertainment | false | false |
| 19 | 13 | Wrath of Man | $56,158 | -73.3% | 82 | -225 | $684 | $27,404,604 | 9 | United Artists Releasing | false | false |
| 20 | 19 | Raya and the Last Dragon | $42,510 | -19.8% | 75 | -45 | $566 | $54,539,253 | 18 | Walt Disney Studios Motion Pictures | false | false |
| 21 | 21 | Witnesses | $30,290 | -28.9% | 33 | -14 | $917 | $668,835 | 5 | Purdie Distribution | false | false |
| 22 | 16 | The Sparks Brothers | $24,950 | -79.1% | 130 | -404 | $191 | $615,870 | 3 | Focus Features | false | false |
| 23 | 20 | Spiral | $23,725 | -53.3% | 102 | -253 | $232 | $23,201,002 | 8 | Lionsgate Films | false | false |
| 24 | 25 | I Carry You with Me | $21,624 | +26.3% | 24 | +20 | $901 | $45,174 | 2 | Sony Pictures Classics | false | false |
| 25 | 18 | Rita Moreno: Just a Girl Who Decided to Go for It | $15,644 | -72.3% | 56 | -153 | $279 | $233,997 | 3 | Roadside Attractions | false | false |
| 26 | 22 | Dream Horse | $14,996 | -46.1% | 73 | - | $205 | $2,807,243 | 7 | Bleecker Street Media | false | false |
| 27 | 28 | The Truffle Hunters | $13,852 | +21% | 25 | +1 | $554 | $458,472 | 18 | Sony Pictures Classics | false | false |
| 28 | 23 | Lansky | $13,614 | -50.4% | 42 | -7 | $324 | $53,384 | 2 | Vertical Entertainment | false | false |
| 29 | - | The God Committee | $12,237 | - | 28 | - | $437 | $12,237 | 1 | Vertical Entertainment | true | false |
| 30 | - | First Date | $8,882 | - | 21 | - | $422 | $8,882 | 1 | Magnolia Pictures | true | false |
| 31 | 27 | Truman & Tennessee: An Intimate Conversation | $8,872 | -23.5% | 21 | -1 | $422 | $41,845 | 3 | Kino Lorber | false | false |
| 32 | 26 | Summer of 85 | $7,961 | -45.9% | 19 | -4 | $419 | $48,916 | 3 | Music Box Films | false | false |
| 33 | - | The Swimming Pool 2021 Re-release | $6,875 | - | 9 | +1 | $763 | $107,414 | 8 | Rialto Distribution | false | false |
| 34 | 29 | The Red Circle 2021 Re-release | $5,925 | -34.4% | 1 | - | $5,925 | $23,163 | 2 | Rialto Pictures | false | false |
| 35 | 32 | The Dry | $4,670 | -14.9% | 7 | -4 | $667 | $351,810 | 7 | IFC Films | false | false |
| 36 | - | The Ladykillers 2021 Re-release | $2,524 | - | 1 | - | $2,524 | $15,296 | 5 | Rialto Pictures | false | false |
| 37 | 37 | Undine | $1,981 | +9.8% | 6 | - | $330 | $71,950 | 5 | IFC Films | false | false |
| 38 | 33 | Censor | $1,976 | -56.4% | 4 | -8 | $494 | $86,027 | 4 | Magnolia Pictures | false | false |
| 39 | - | Lydia Lunch: The War Is Never Over | $1,710 | - | 1 | - | $1,710 | $1,710 | 1 | Kino Lorber | true | false |
| 40 | 44 | About Endlessness | $1,419 | +236.3% | 1 | - | $1,419 | $47,488 | 10 | Magnolia Pictures | false | false |
| 41 | 31 | Our Ladies | $1,112 | -81.4% | 12 | -13 | $92 | $26,118 | 3 | Sony Pictures Releasing | false | false |
| 42 | - | Operation Portugal | $733 | - | 10 | - | $73 | $733 | 1 | Sony Pictures Releasing | true | false |
| 43 | 42 | Together Together | $476 | -48.2% | 4 | - | $119 | $1,436,146 | 11 | Bleecker Street Media | false | false |
| 44 | 39 | Holler | $253 | -80.6% | 4 | -2 | $63 | $28,309 | 4 | IFC Films | false | false |
| 45 | 45 | The Evil Next Door | $128 | -57.8% | 2 | -1 | $64 | $672 | 2 | Magnolia Pictures | false | false |
