| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Mr. Popper's Penguins | $341,709 | - | 62 | - | $5,511 | $341,709 | 1 | 20th Century Fox International | true | false |
| 2 | 1 | Green Lantern | $243,897 | -42.7% | 63 | -14 | $3,871 | $2,129,880 | 3 | Warner Bros. | false | false |
| 3 | 2 | Er Conde Jones | $219,759 | -41.8% | 49 | -9 | $4,484 | $2,948,126 | 4 | N/A | false | false |
| 4 | 3 | Friends with Benefits | $218,007 | -19.4% | 50 | -1 | $4,360 | $722,037 | 2 | Sony Pictures Releasing | false | false |
| 5 | 4 | Cars 2 | $118,315 | -42.3% | 57 | -21 | $2,075 | $4,307,676 | 5 | Walt Disney Pictures | false | false |
| 6 | - | Garfield's Pet Force | $96,917 | - | 31 | - | $3,126 | $143,359 | 1 | N/A | true | false |
| 7 | - | The Dilemma | $77,066 | - | 31 | - | $2,486 | $77,066 | 1 | United International Pictures | true | false |
| 8 | 5 | The Smurfs | $62,925 | -56.8% | 51 | -28 | $1,233 | $7,651,809 | 7 | Sony Pictures Releasing | false | false |
| 9 | 8 | Saluda al diablo de mi parte | $43,790 | -32.8% | 18 | - | $2,432 | $161,292 | 2 | N/A | false | false |
| 10 | 7 | Insidious | $43,290 | -34.7% | 18 | -2 | $2,405 | $171,228 | 2 | N/A | false | false |
| 11 | 6 | Limitless | $27,776 | -62.3% | 14 | -11 | $1,984 | $575,586 | 4 | N/A | false | false |
| 12 | 9 | Crazy, Stupid, Love. | $20,354 | -67.8% | 15 | -14 | $1,356 | $1,004,389 | 5 | Warner Bros. | false | false |
| 13 | 10 | Horrible Bosses | $19,216 | -48.3% | 6 | -9 | $3,202 | $1,318,795 | 7 | Warner Bros. | false | false |
| 14 | 12 | Igor | $4,382 | -78.7% | 16 | -6 | $273 | $45,835 | 2 | N/A | false | false |
| 15 | 15 | Solitary Man | $2,713 | -44.4% | 5 | - | $542 | $86,757 | 4 | N/A | false | false |
| 16 | 13 | Zookeeper | $2,553 | -84.6% | 7 | -12 | $364 | $4,015,011 | 9 | Sony Pictures Releasing | false | false |
| 17 | 14 | Paul | $2,545 | -82.7% | 5 | -23 | $509 | $167,098 | 3 | United International Pictures | false | false |
| 18 | 17 | You Will Meet a Tall Dark Stranger | $2,501 | -9.2% | 1 | -1 | $2,501 | $90,336 | 6 | N/A | false | false |
| 19 | 11 | Season of the Witch | $1,968 | -91.5% | 2 | -6 | $984 | $755,919 | 6 | N/A | false | false |
| 20 | 18 | The Beaver | $693 | -71.1% | 2 | -2 | $346 | $179,986 | 6 | N/A | false | false |
| 21 | 16 | Skyline | $450 | -87.2% | 2 | -6 | $225 | $147,640 | 5 | N/A | false | false |
