| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Fast Five | $863,090 | - | 99 | - | $8,718 | $863,090 | 1 | United International Pictures | true | false |
| 2 | 1 | Pirates of the Caribbean: On Stranger Tides | $693,768 | -23% | 94 | -5 | $7,380 | $4,191,193 | 3 | Walt Disney Pictures | false | false |
| 3 | 2 | The Hangover Part II | $307,519 | -20.7% | 53 | -9 | $5,802 | $1,054,291 | 2 | Warner Bros. | false | false |
| 4 | 3 | Big Mommas: Like Father, Like Son | $95,653 | -40.8% | 40 | -1 | $2,391 | $1,137,677 | 4 | 20th Century Fox International | false | false |
| 5 | 4 | Rio | $88,420 | -43.9% | 48 | -12 | $1,842 | $8,057,981 | 9 | 20th Century Fox International | false | false |
| 6 | 6 | The Crazies | $37,543 | -35.6% | 11 | -4 | $3,413 | $142,820 | 2 | N/A | false | false |
| 7 | 10 | Beyond a Reasonable Doubt | $22,628 | -30.4% | 12 | -3 | $1,885 | $74,114 | 2 | N/A | false | false |
| 8 | 5 | Thor | $19,543 | -66.9% | 24 | -18 | $814 | $2,605,564 | 6 | United International Pictures | false | false |
| 9 | 8 | Priest | $16,983 | -63.4% | 12 | -27 | $1,415 | $838,443 | 4 | Sony Pictures Releasing | false | false |
| 10 | 13 | El último cuerpo | $14,275 | +19.4% | 12 | -4 | $1,189 | $112,101 | 4 | N/A | false | false |
| 11 | 9 | Gnomeo & Juliet | $13,694 | -58.2% | 14 | -11 | $978 | $455,497 | 5 | N/A | false | false |
| 12 | 7 | The Switch | $8,405 | -83.4% | 3 | -12 | $2,801 | $438,164 | 4 | N/A | false | false |
| 13 | 11 | Love & Other Drugs | $7,937 | -49% | 4 | -5 | $1,984 | $127,444 | 3 | 20th Century Fox International | false | false |
| 14 | 14 | The Rebound | $6,926 | -33.9% | 5 | - | $1,385 | $70,323 | 4 | N/A | false | false |
| 15 | 15 | Biutiful | $6,803 | -23.6% | 2 | -1 | $3,401 | $39,923 | 3 | N/A | false | false |
| 16 | 12 | Just Go with It | $2,816 | -77.7% | 3 | -9 | $938 | $2,805,280 | 8 | Sony Pictures Releasing | false | false |
| 17 | 16 | Hop | $558 | -84.6% | 1 | -6 | $558 | $1,325,153 | 8 | United International Pictures | false | false |
| 18 | 20 | 127 Hours | $184 | -80% | 1 | - | $184 | $50,920 | 4 | 20th Century Fox International | false | false |
| 19 | 19 | African Cats | $85 | -90.9% | 1 | -2 | $85 | $39,973 | 7 | Walt Disney Pictures | false | false |
