| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Pirates of the Caribbean: On Stranger Tides | $1,138,344 | - | 109 | - | $10,443 | $1,205,560 | 1 | Walt Disney Pictures | true | false |
| 2 | 1 | Rio | $245,648 | -35.1% | 69 | +8 | $3,560 | $7,622,712 | 7 | 20th Century Fox International | false | false |
| 3 | 4 | Big Mommas: Like Father, Like Son | $220,327 | -1.3% | 47 | +8 | $4,687 | $648,795 | 2 | 20th Century Fox International | false | false |
| 4 | 3 | Thor | $134,849 | -47.3% | 63 | +3 | $2,140 | $2,426,895 | 4 | United International Pictures | false | false |
| 5 | 2 | Priest | $128,473 | -63.3% | 59 | -17 | $2,177 | $676,678 | 2 | Sony Pictures Releasing | false | false |
| 6 | 6 | The Switch | $82,869 | -31.8% | 28 | +3 | $2,959 | $296,876 | 2 | N/A | false | false |
| 7 | - | Love & Other Drugs | $50,499 | - | 20 | - | $2,524 | $50,499 | 1 | 20th Century Fox International | true | false |
| 8 | 7 | Gnomeo & Juliet | $47,160 | -50.6% | 31 | -3 | $1,521 | $380,045 | 3 | N/A | false | false |
| 9 | 5 | Just Go with It | $41,774 | -70.9% | 23 | -37 | $1,816 | $2,760,125 | 6 | Sony Pictures Releasing | false | false |
| 10 | 9 | El último cuerpo | $25,091 | +29.3% | 24 | +3 | $1,045 | $59,503 | 2 | N/A | false | false |
| 11 | 12 | The Rebound | $15,557 | +83.7% | 6 | +1 | $2,592 | $37,436 | 2 | N/A | false | false |
| 12 | - | Biutiful | $10,520 | - | 4 | - | $2,630 | $10,520 | 1 | N/A | true | false |
| 13 | 10 | Hop | $6,477 | -63.6% | 20 | -17 | $323 | $1,317,540 | 6 | United International Pictures | false | false |
| 14 | 11 | Hall Pass | $5,637 | -42.6% | 3 | -2 | $1,879 | $1,099,860 | 8 | Warner Bros. | false | false |
| 15 | 8 | 127 Hours | $4,751 | -77.2% | 7 | -1 | $678 | $44,500 | 2 | 20th Century Fox International | false | false |
| 16 | 17 | Mother and Child | $2,969 | +3% | 2 | -1 | $1,484 | $29,941 | 3 | N/A | false | false |
| 17 | 15 | I Spit on Your Grave | $2,449 | -46.4% | 4 | -1 | $612 | $91,354 | 3 | N/A | false | false |
| 18 | 21 | The Ghost Writer | $2,172 | +182.8% | 1 | - | $2,172 | $64,868 | 4 | N/A | false | false |
| 19 | 13 | The Roommate | $1,324 | -82.3% | 5 | -6 | $264 | $232,725 | 4 | Sony Pictures Releasing | false | false |
| 20 | 16 | Black Swan | $1,293 | -64.7% | 2 | - | $646 | $427,527 | 5 | 20th Century Fox International | false | false |
| 21 | 20 | A Turtle's Tale: Sammy's Adventures | $886 | +5.7% | 4 | +1 | $221 | $611,720 | 9 | N/A | false | false |
| 22 | 18 | African Cats | $397 | -77.9% | 2 | -6 | $198 | $38,473 | 5 | Walt Disney Pictures | false | false |
