| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Little Fockers | $236,621 | - | 72 | - | $3,286 | $236,621 | 1 | United International Pictures | true | false |
| 2 | 1 | Megamind | $135,216 | -79.1% | 74 | - | $1,827 | $1,183,235 | 2 | United International Pictures | false | false |
| 3 | 3 | The Chronicles of Narnia: The Voyage of the Dawn Treader | $116,230 | -47.2% | 92 | -16 | $1,263 | $1,398,600 | 3 | NuMetro Distribution | false | false |
| 4 | 2 | Due Date | $91,718 | -75.2% | 61 | - | $1,503 | $664,257 | 2 | NuMetro Distribution | false | false |
| 5 | 4 | Spud | $84,190 | -50.6% | 85 | +1 | $990 | $1,748,005 | 4 | NuMetro Distribution | false | false |
| 6 | - | Yogi Bear | $39,633 | - | 52 | - | $762 | $39,633 | 1 | NuMetro Distribution | true | false |
| 7 | 5 | Harry Potter and the Deathly Hallows: Part 1 | $37,741 | -62% | 51 | -30 | $740 | $2,115,533 | 5 | NuMetro Distribution | false | false |
| 8 | 6 | Liefling | $36,607 | -57.1% | 51 | -8 | $717 | $1,685,386 | 6 | Indigenous Film Distribution | false | false |
| 9 | 7 | Faster | $26,437 | -46.9% | 21 | -13 | $1,258 | $403,907 | 4 | Ster-Kinekor Pictures | false | false |
| 10 | 8 | RED | $22,866 | -42.5% | 23 | -3 | $994 | $731,303 | 6 | NuMetro Distribution | false | false |
| 11 | 11 | Unstoppable | $19,704 | -34.6% | 27 | -3 | $729 | $891,549 | 7 | NuMetro Distribution | false | false |
| 12 | 10 | Paranormal Activity 2 | $15,141 | -55.2% | 12 | -3 | $1,261 | $175,985 | 3 | United International Pictures | false | false |
| 13 | - | Eternity | $14,387 | - | 28 | - | $513 | $14,387 | 1 | Indigenous Film Distribution | true | false |
| 14 | 12 | The American | $6,806 | -73.4% | 10 | -14 | $680 | $274,922 | 4 | Ster-Kinekor Pictures | false | false |
| 15 | 19 | The Social Network | $5,010 | +42.8% | 4 | +1 | $1,252 | $376,345 | 8 | Ster-Kinekor Pictures | false | false |
| 16 | 15 | You Again | $4,174 | -48.3% | 3 | -3 | $1,391 | $372,055 | 8 | Ster-Kinekor Pictures | false | false |
| 17 | 16 | Takers 2010 Re-release | $4,024 | -37.6% | 6 | -3 | $670 | $460,897 | 9 | Ster-Kinekor Pictures | false | false |
| 18 | 9 | Stoute Boudjies | $3,734 | -89.5% | 7 | -28 | $533 | $181,679 | 3 | Ster-Kinekor Pictures | false | false |
| 19 | - | Wolf 2010 Re-release | $2,864 | - | 4 | - | $716 | $2,864 | 1 | Ster-Kinekor Pictures | true | false |
| 20 | 18 | Jackass 3D | $2,432 | -45.7% | 1 | -2 | $2,432 | $506,596 | 6 | United International Pictures | false | false |
| 21 | 17 | Despicable Me | $2,155 | -61.9% | 3 | -2 | $718 | $2,345,587 | 13 | United International Pictures | false | false |
| 22 | 21 | Eat Pray Love | $1,432 | -27.6% | 4 | - | $358 | $1,826,482 | 12 | Sony Pictures Releasing | false | false |
| 23 | 20 | Coco Chanel & Igor Stravinsky | $1,204 | -45.4% | 3 | - | $401 | $37,412 | 5 | United International Pictures | false | false |
| 24 | 23 | The Kids Are All Right | $1,183 | +18.9% | 2 | +1 | $591 | $41,628 | 7 | United International Pictures | false | false |
| 25 | 14 | Scott Pilgrim vs. the World | $1,111 | -87.2% | 5 | -4 | $222 | $82,696 | 4 | United International Pictures | false | false |
