| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Megamind | $455,096 | - | 92 | - | $4,946 | $545,463 | 1 | United International Pictures | true | false |
| 2 | 1 | Tangled | $444,002 | -38.2% | 78 | - | $5,692 | $2,968,223 | 3 | Walt Disney Pictures | false | false |
| 3 | 2 | Harry Potter and the Deathly Hallows: Part 1 | $286,741 | -34.7% | 95 | -1 | $3,018 | $3,626,386 | 4 | Warner Bros. | false | false |
| 4 | - | The Last Exorcism | $99,226 | - | 28 | - | $3,543 | $99,226 | 1 | N/A | true | false |
| 5 | 4 | The Zero Hour | $98,114 | -12.8% | 43 | +1 | $2,281 | $2,613,869 | 10 | N/A | false | false |
| 6 | 3 | The Social Network | $72,898 | -42.8% | 31 | -4 | $2,351 | $304,160 | 2 | Sony Pictures Releasing | false | false |
| 7 | 5 | 9 meses | $48,933 | -16% | 25 | +1 | $1,957 | $496,923 | 5 | N/A | false | false |
| 8 | - | Takers 2010 Re-release | $44,320 | - | 30 | - | $1,477 | $44,320 | 1 | Sony Pictures Releasing | true | false |
| 9 | 9 | Muerte en alto contraste | $23,903 | -26.8% | 21 | -1 | $1,138 | $159,989 | 3 | N/A | false | false |
| 10 | 6 | Life as We Know It | $18,940 | -65.9% | 19 | -17 | $996 | $901,535 | 5 | Warner Bros. | false | false |
| 11 | 7 | Wall Street: Money Never Sleeps | $6,449 | -86.3% | 5 | -31 | $1,289 | $254,351 | 3 | 20th Century Fox International | false | false |
| 12 | 8 | Paranormal Activity 2 | $5,580 | -85% | 11 | -12 | $507 | $924,698 | 6 | United International Pictures | false | false |
| 13 | - | I Served the King of England 2010 Re-release | $4,918 | - | 2 | - | $2,459 | $4,918 | 1 | N/A | true | false |
| 14 | 10 | Solomon Kane | $2,684 | -84.4% | 4 | -15 | $671 | $312,949 | 5 | N/A | false | false |
| 15 | 13 | Eat Pray Love | $2,630 | -47.8% | 2 | -2 | $1,315 | $570,588 | 7 | Sony Pictures Releasing | false | false |
| 16 | 16 | Vampires Suck | $1,848 | +42.3% | 6 | +3 | $308 | $404,239 | 7 | 20th Century Fox International | false | false |
| 17 | 14 | Tinker Bell and the Great Fairy Rescue | $1,282 | -56.6% | 7 | -3 | $183 | $338,292 | 12 | Walt Disney Pictures | false | false |
| 18 | 15 | Legend of the Guardians: The Owls of Ga'Hoole | $969 | -32.2% | 6 | -5 | $161 | $1,785,409 | 11 | Warner Bros. | false | false |
| 19 | 12 | Due Date | $554 | -89.3% | 3 | -7 | $184 | $614,876 | 6 | Warner Bros. | false | false |
| 20 | 18 | Despicable Me | $533 | -47.8% | 4 | -1 | $133 | $2,321,604 | 18 | United International Pictures | false | false |
| 21 | 17 | Furry Vengeance | $383 | -66.5% | 4 | -2 | $95 | $899,826 | 15 | N/A | false | false |
