| Est. Rank | Rank | Diff | Release
| Est. Gross | Actual | Diff | % Diff | Theaters | Estimated Total | Actual | Weekend | Distributor
| New This Week
|
|---|
| 1 | 1 | - | Harry Potter and the Deathly Hallows: Part 1 | $50,345,000 | $49,087,101 | -$1,257,899 | -2.5% | 4,125 | $220,352,000 | $219,056,129 | 2 | Warner Bros. | - |
| 2 | 2 | - | Tangled | $49,100,000 | $48,767,052 | -$332,948 | -0.7% | 3,603 | $69,000,000 | $68,706,298 | 1 | Walt Disney Studios Motion Pictures | - |
| 3 | 3 | - | Megamind | $12,850,000 | $12,575,778 | -$274,222 | -2.1% | 3,411 | $130,466,000 | $130,218,934 | 4 | DreamWorks | - |
| 4 | 4 | - | Burlesque | $11,800,000 | $11,947,744 | +$147,744 | +1.3% | 3,037 | $17,150,000 | $17,300,213 | 1 | Screen Gems | - |
| 5 | 5 | - | Unstoppable | $11,750,000 | $11,432,903 | -$317,097 | -2.7% | 3,183 | $60,726,000 | $60,442,621 | 3 | Twentieth Century Fox | - |
| 6 | 6 | - | Love & Other Drugs | $9,850,000 | $9,739,161 | -$110,839 | -1.1% | 2,455 | $14,000,000 | $13,901,532 | 1 | Twentieth Century Fox | - |
| 7 | 7 | - | Faster | $8,708,000 | $8,523,153 | -$184,847 | -2.1% | 2,454 | $12,200,000 | $12,002,840 | 1 | CBS Films | - |
| 8 | 8 | - | Due Date | $7,300,000 | $7,167,885 | -$132,115 | -1.8% | 2,555 | $85,018,000 | $84,861,008 | 4 | Warner Bros. | - |
| 9 | 9 | - | The Next Three Days | $4,840,000 | $4,683,123 | -$156,877 | -3.2% | 2,564 | $14,551,000 | $14,392,072 | 2 | Lionsgate | - |
| 10 | 10 | - | Morning Glory | $4,030,000 | $3,910,058 | -$119,942 | -3% | 2,441 | $26,451,000 | $26,340,571 | 3 | Paramount Pictures | - |
| 11 | 11 | - | 127 Hours | $1,725,000 | $1,708,883 | -$16,117 | -0.9% | 293 | $4,441,000 | $4,420,168 | 4 | Fox Searchlight Pictures | - |
| 12 | 12 | - | Fair Game | $1,583,000 | $1,560,189 | -$22,811 | -1.4% | 396 | $5,976,000 | $5,958,797 | 4 | Summit Entertainment | - |
| 13 | 14 | +1 | For Colored Girls | $1,415,000 | $1,362,287 | -$52,713 | -3.7% | 605 | $36,630,000 | $36,564,364 | 4 | Lionsgate | - |
| 14 | 13 | -1 | Red | $1,385,000 | $1,375,685 | -$9,315 | -0.7% | 914 | $86,141,000 | $86,117,412 | 7 | Summit Entertainment | - |
| 15 | 15 | - | Skyline | $1,108,000 | $1,141,440 | +$33,440 | +3% | 1,189 | $20,182,000 | $20,215,790 | 3 | Universal Pictures | - |
| 16 | 16 | - | The Social Network | $750,000 | $707,153 | -$42,847 | -5.7% | 291 | $90,462,000 | $90,423,986 | 9 | Sony Pictures Releasing | - |
| 17 | 17 | - | Secretariat | $656,000 | $647,172 | -$8,828 | -1.3% | 501 | $57,559,000 | $57,547,263 | 8 | Walt Disney Studios Motion Pictures | - |
| 18 | 18 | - | The Girl Who Kicked the Hornet's Nest | $439,000 | $390,888 | -$48,112 | -11% | 168 | $4,036,000 | $4,011,260 | 5 | Music Box Films | - |
| 19 | 20 | +1 | The King's Speech | $350,000 | $355,450 | +$5,450 | +1.6% | 4 | $350,000 | $355,450 | 1 | The Weinstein Company | - |
| 20 | 19 | -1 | Despicable Me | $349,000 | $363,090 | +$14,090 | +4% | 266 | - | $249,724,650 | 21 | Universal Pictures | - |
| 21 | 23 | +2 | Paranormal Activity 2 | $215,000 | $220,108 | +$5,108 | +2.4% | 279 | $84,101,000 | $84,105,661 | 6 | Paramount Pictures | - |
| 22 | 28 | +6 | Jackass 3D | $190,000 | $182,055 | -$7,945 | -4.2% | 183 | $116,573,000 | $116,563,800 | 7 | Paramount Pictures | - |
| 23 | 29 | +6 | Alpha and Omega | $165,000 | $165,947 | +$947 | +0.6% | 228 | $25,078,000 | $25,077,977 | 11 | Lionsgate | - |
| 24 | 39 | +15 | The Nutcracker: The Untold Story | $68,000 | $65,944 | -$2,056 | -3% | 42 | $89,000 | $87,539 | 1 | Freestyle Releasing | - |
| 25 | 41 | +16 | Waiting for Superman | $62,000 | $60,563 | -$1,437 | -2.3% | 69 | $6,254,000 | $6,252,794 | 10 | Paramount Vantage | - |
