| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Life as We Know It | $157,853 | -20.4% | 70 | +9 | $2,255 | $442,538 | 2 | NuMetro Distribution | false | false |
| 2 | 2 | Despicable Me | $106,363 | -6.8% | 39 | -25 | $2,727 | $1,908,086 | 6 | United International Pictures | false | false |
| 3 | - | The Social Network | $91,706 | - | 40 | - | $2,292 | $91,706 | 1 | Ster-Kinekor Pictures | true | false |
| 4 | 3 | Eat Pray Love | $90,198 | -13.7% | 74 | -6 | $1,218 | $1,542,730 | 5 | Sony Pictures Releasing | false | false |
| 5 | 5 | Takers 2010 Re-release | $73,063 | -13% | 40 | - | $1,826 | $209,216 | 2 | Ster-Kinekor Pictures | false | false |
| 6 | 4 | Piranha 3D | $70,165 | -31.1% | 33 | - | $2,126 | $223,174 | 2 | Ster-Kinekor Pictures | false | false |
| 7 | 6 | Alpha and Omega | $62,127 | -9.5% | 51 | -1 | $1,218 | $304,732 | 3 | NuMetro Distribution | false | false |
| 8 | - | You Again | $62,100 | - | 30 | - | $2,070 | $62,100 | 1 | Ster-Kinekor Pictures | true | false |
| 9 | 7 | The Switch | $46,020 | -17.1% | 37 | - | $1,243 | $464,549 | 4 | NuMetro Distribution | false | false |
| 10 | 9 | The Other Guys | $45,982 | -12.2% | 38 | -7 | $1,210 | $1,108,458 | 7 | Sony Pictures Releasing | false | false |
| 11 | 8 | Charlie St. Cloud | $35,328 | -33.2% | 25 | -20 | $1,413 | $231,578 | 3 | United International Pictures | false | false |
| 12 | - | The Girl Who Played with Fire | $31,115 | - | 14 | - | $2,222 | $31,115 | 1 | NuMetro Distribution | true | false |
| 13 | 12 | The Girl with the Dragon Tattoo | $22,606 | -2.3% | 12 | -3 | $1,883 | $177,768 | 4 | NuMetro Distribution | false | false |
| 14 | - | Action Replayy | $21,963 | - | 10 | - | $2,196 | $21,963 | 1 | NuMetro Distribution | true | false |
| 15 | 10 | The Karate Kid | $19,798 | -37.5% | 29 | -8 | $682 | $1,826,914 | 8 | Sony Pictures Releasing | false | false |
| 16 | - | Golmaal 3 | $19,144 | - | 8 | - | $2,393 | $19,144 | 1 | NuMetro Distribution | true | false |
| 17 | 11 | Why Did I Get Married Too? | $18,921 | -25.1% | 22 | -3 | $860 | $520,114 | 6 | Ster-Kinekor Pictures | false | false |
| 18 | - | The Infidel | $9,556 | - | 9 | - | $1,061 | $9,556 | 1 | United International Pictures | true | false |
| 19 | 18 | The Last Airbender | $4,149 | -31.5% | 4 | -8 | $1,037 | $1,367,134 | 9 | United International Pictures | false | false |
| 20 | 19 | Four Lions | $734 | -75.2% | 5 | - | $146 | $5,389 | 2 | United International Pictures | false | false |
