| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Life as We Know It | $198,329 | - | 61 | - | $3,251 | $198,329 | 1 | NuMetro Distribution | true | false |
| 2 | 2 | Despicable Me | $114,083 | -39.5% | 64 | -22 | $1,782 | $1,717,650 | 5 | United International Pictures | false | false |
| 3 | 1 | Eat Pray Love | $104,526 | -45.9% | 80 | -4 | $1,306 | $1,344,753 | 4 | Sony Pictures Releasing | false | false |
| 4 | - | Piranha 3D | $101,770 | - | 33 | - | $3,083 | $101,770 | 1 | Ster-Kinekor Pictures | true | false |
| 5 | - | Takers 2010 Re-release | $84,011 | - | 40 | - | $2,100 | $84,011 | 1 | Ster-Kinekor Pictures | true | false |
| 6 | 3 | Alpha and Omega | $68,682 | -45.1% | 52 | -1 | $1,320 | $220,259 | 2 | NuMetro Distribution | false | false |
| 7 | 4 | The Switch | $55,542 | -48.3% | 37 | - | $1,501 | $379,587 | 3 | NuMetro Distribution | false | false |
| 8 | 5 | Charlie St. Cloud | $52,849 | -41.2% | 45 | - | $1,174 | $174,990 | 2 | United International Pictures | false | false |
| 9 | 6 | The Other Guys | $52,382 | -39% | 45 | -6 | $1,164 | $1,001,249 | 6 | Sony Pictures Releasing | false | false |
| 10 | 7 | The Karate Kid | $31,675 | -45% | 37 | -24 | $856 | $1,740,185 | 7 | Sony Pictures Releasing | false | false |
| 11 | 8 | Why Did I Get Married Too? | $25,274 | -39.6% | 25 | -5 | $1,010 | $473,736 | 5 | Ster-Kinekor Pictures | false | false |
| 12 | 9 | The Girl with the Dragon Tattoo | $23,139 | -41.2% | 15 | - | $1,542 | $136,433 | 3 | NuMetro Distribution | false | false |
| 13 | 10 | The Joneses | $16,588 | -57.4% | 20 | - | $829 | $70,872 | 2 | Ster-Kinekor Pictures | false | false |
| 14 | 12 | Machete | $14,050 | -48.5% | 20 | - | $702 | $57,297 | 2 | Sony Pictures Releasing | false | false |
| 15 | 13 | Wall Street: Money Never Sleeps | $13,765 | -39.3% | 24 | +1 | $573 | $409,571 | 6 | 20th Century Fox International | false | false |
| 16 | - | Knucklehead | $7,927 | - | 9 | - | $880 | $7,927 | 1 | NuMetro Distribution | true | false |
| 17 | 17 | Mao's Last Dancer | $6,340 | -34.5% | 9 | - | $704 | $428,842 | 13 | NuMetro Distribution | false | false |
| 18 | 15 | The Last Airbender | $6,053 | -63.5% | 12 | -20 | $504 | $1,318,511 | 8 | United International Pictures | false | false |
| 19 | - | Four Lions | $2,959 | - | 5 | - | $591 | $29,596 | 1 | United International Pictures | true | false |
| 20 | 19 | The End of the Line 2010 Re-release | $1,157 | -71.3% | 6 | - | $192 | $6,696 | 2 | United International Pictures | false | false |
| 21 | 20 | London River 2010 Re-release | $238 | -65.1% | 1 | - | $238 | $54,261 | 11 | United International Pictures | false | false |
