| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Saw 3D | $625,792 | - | 80 | - | $7,822 | $646,649 | 1 | Cineplex | true | false |
| 2 | 1 | Paranormal Activity 2 | $287,783 | -24% | 65 | - | $4,427 | $939,383 | 2 | United International Pictures | false | false |
| 3 | - | Due Date | $167,992 | - | 65 | - | $2,584 | $167,992 | 1 | Warner Bros. | true | false |
| 4 | 3 | Life as We Know It | $98,863 | -17.9% | 43 | -1 | $2,299 | $302,907 | 2 | Warner Bros. | false | false |
| 5 | 4 | Eat Pray Love | $43,401 | -20.8% | 25 | - | $1,736 | $808,697 | 6 | Sony Pictures Releasing | false | false |
| 6 | - | Rage | $36,378 | - | 25 | - | $1,455 | $36,444 | 1 | Cine Colombia | true | false |
| 7 | 2 | Piranha 3D | $31,610 | -77.3% | 37 | -33 | $854 | $676,780 | 3 | Cineplex | false | false |
| 8 | 7 | The Collector | $27,870 | -29.7% | 27 | +1 | $1,032 | $255,806 | 4 | Venus | false | false |
| 9 | 6 | Legend of the Guardians: The Owls of Ga'Hoole | $26,940 | -41.3% | 40 | -30 | $673 | $2,310,466 | 6 | Warner Bros. | false | false |
| 10 | 8 | Tinker Bell and the Great Fairy Rescue | $24,092 | -16.1% | 39 | -3 | $617 | $418,842 | 5 | Walt Disney Pictures | false | false |
| 11 | 5 | The Town | $22,102 | -52.9% | 23 | -16 | $960 | $417,040 | 4 | Warner Bros. | false | false |
| 12 | 11 | Takers 2010 Re-release | $13,228 | +13.2% | 30 | - | $440 | $148,360 | 4 | Sony Pictures Releasing | false | false |
| 13 | 10 | A Single Man | $10,002 | -26% | 9 | -2 | $1,111 | $33,511 | 2 | - | false | false |
| 14 | 9 | Avatar 2010 Special Edition | $6,786 | -49.8% | 11 | - | $616 | - | 5 | 20th Century Fox International | false | false |
| 15 | 21 | Despicable Me | $2,992 | +47.4% | 9 | -5 | $332 | $2,748,308 | 15 | Universal Pictures International (UPI) | false | false |
| 16 | 12 | Inception | $2,606 | -62.6% | 3 | -4 | $868 | $3,144,672 | 14 | Warner Bros. | false | false |
| 17 | 18 | Cats & Dogs: The Revenge of Kitty Galore | $2,343 | -31.8% | 10 | -12 | $234 | $2,090,090 | 13 | Warner Bros. | false | false |
| 18 | 17 | Grown Ups | $1,972 | -46.1% | 50 | - | $39 | $994,367 | 14 | Sony Pictures Releasing | false | false |
| 19 | 20 | Vampires Suck | $1,215 | -58.7% | 1 | -2 | $1,215 | $246,857 | 10 | 20th Century Fox International | false | false |
| 20 | 16 | Micmacs | $989 | -80.1% | 10 | - | $98 | $52,380 | 5 | Sony Pictures Releasing | false | false |
| 21 | 19 | The Burning Plain | $863 | -71.6% | 2 | -4 | $431 | $68,252 | 8 | Cine Colombia | false | false |
| 22 | 15 | The Box | $109 | -98% | 1 | -7 | $109 | $137,384 | 8 | Cine Colombia | false | false |
| 23 | 22 | The Last Airbender | $49 | -97.6% | 2 | -9 | $24 | $3,408,130 | 11 | United International Pictures | false | false |
| 24 | 14 | Wall Street: Money Never Sleeps | $41 | -99.3% | 1 | -10 | $41 | $464,834 | 7 | 20th Century Fox International | false | false |
| 25 | 24 | Halloween II | $13 | -98.6% | 2 | -1 | $6 | $118,926 | 11 | Cine Colombia | false | false |
| 26 | 25 | From Paris with Love | $11 | -98.6% | 1 | -1 | $11 | $173,997 | 8 | - | false | false |
| 27 | 28 | Going the Distance | $11 | -83.8% | 1 | - | $11 | $305,525 | 8 | Warner Bros. | false | false |
| 28 | 27 | Shrek Forever After | $5 | -99.3% | 2 | -1 | $2 | $6,688,109 | 18 | United International Pictures | false | false |
| 29 | 26 | Daybreakers | $5 | -99.4% | 1 | - | $5 | $132,270 | 10 | Venus | false | false |
| 30 | 23 | Oceans | $5 | -99.5% | 1 | -2 | $5 | $548,608 | 12 | Cine Colombia | false | false |
