| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Paranormal Activity 2 | $378,473 | - | 65 | - | $5,822 | $401,183 | 1 | United International Pictures | true | false |
| 2 | 1 | Piranha 3D | $139,507 | -50.9% | 70 | -24 | $1,992 | $542,432 | 2 | Cineplex | false | false |
| 3 | - | Life as We Know It | $120,442 | - | 44 | - | $2,737 | $120,442 | 1 | Warner Bros. | true | false |
| 4 | 4 | Eat Pray Love | $54,822 | -35.2% | 25 | - | $2,192 | $729,748 | 5 | Sony Pictures Releasing | false | false |
| 5 | 3 | The Town | $46,917 | -47.5% | 39 | -8 | $1,203 | $368,148 | 3 | Warner Bros. | false | false |
| 6 | 2 | Legend of the Guardians: The Owls of Ga'Hoole | $45,913 | -68.1% | 70 | -55 | $655 | $2,306,994 | 5 | Warner Bros. | false | false |
| 7 | 6 | The Collector | $39,652 | +2.2% | 26 | - | $1,525 | $198,614 | 3 | Venus | false | false |
| 8 | 5 | Tinker Bell and the Great Fairy Rescue | $28,703 | -36.2% | 42 | - | $683 | $384,290 | 4 | Walt Disney Pictures | false | false |
| 9 | 8 | Avatar 2010 Special Edition | $13,526 | -32.6% | 11 | -7 | $1,229 | $386,690 | 4 | 20th Century Fox International | false | false |
| 10 | - | A Single Man | $13,516 | - | 11 | - | $1,228 | $13,516 | 1 | - | true | false |
| 11 | 10 | Takers 2010 Re-release | $11,685 | -39.1% | 30 | - | $389 | $125,380 | 3 | Sony Pictures Releasing | false | false |
| 12 | 11 | Inception | $6,969 | -62.4% | 7 | -5 | $995 | $3,211,038 | 13 | Warner Bros. | false | false |
| 13 | 7 | Resident Evil: Afterlife | $6,254 | -70.7% | 69 | +45 | $90 | $3,124,133 | 8 | Sony Pictures Releasing | false | false |
| 14 | 9 | Wall Street: Money Never Sleeps | $6,059 | -69% | 11 | -8 | $550 | $470,834 | 6 | 20th Century Fox International | false | false |
| 15 | 20 | The Box | $5,378 | +25.6% | 8 | +1 | $672 | $140,514 | 7 | Cine Colombia | false | false |
| 16 | 14 | Micmacs | $4,978 | -25.1% | 10 | - | $497 | $47,209 | 4 | Sony Pictures Releasing | false | false |
| 17 | 17 | Grown Ups | $3,659 | -42.7% | 50 | +44 | $73 | $989,324 | 13 | Sony Pictures Releasing | false | false |
| 18 | 15 | Cats & Dogs: The Revenge of Kitty Galore | $3,436 | -47.6% | 22 | -8 | $156 | $2,134,984 | 12 | Warner Bros. | false | false |
| 19 | 24 | The Burning Plain | $3,044 | +110.5% | 6 | +2 | $507 | $66,777 | 7 | Cine Colombia | false | false |
| 20 | 12 | Vampires Suck | $2,945 | -69.7% | 3 | -7 | $981 | $248,852 | 9 | 20th Century Fox International | false | false |
| 21 | 18 | Despicable Me | $2,030 | -66.7% | 14 | -19 | $145 | $2,808,009 | 14 | Universal Pictures International (UPI) | false | false |
| 22 | 13 | The Last Airbender | $2,029 | -75.1% | 11 | -21 | $184 | $3,486,714 | 10 | United International Pictures | false | false |
| 23 | 19 | Oceans | $1,059 | -75.4% | 3 | -10 | $353 | $561,544 | 11 | Cine Colombia | false | false |
| 24 | 23 | Halloween II | $951 | -38.8% | 3 | -2 | $317 | $121,718 | 10 | Cine Colombia | false | false |
| 25 | 16 | From Paris with Love | $795 | -87.7% | 2 | -9 | $397 | $178,090 | 7 | - | false | false |
| 26 | 22 | Daybreakers | $784 | -61.7% | 1 | -2 | $784 | $135,385 | 9 | Venus | false | false |
| 27 | 25 | Shrek Forever After | $684 | +1% | 3 | - | $228 | $6,845,868 | 17 | United International Pictures | false | false |
| 28 | 21 | Going the Distance | $68 | -96.8% | 1 | -4 | $68 | $312,721 | 7 | Warner Bros. | false | false |
