| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Despicable Me | $51,603 | -27.7% | 18 | - | $2,866 | $142,974 | 2 | United International Pictures | false | false |
| 2 | - | The Other Guys | $29,444 | - | 7 | - | $4,206 | $29,444 | 1 | Sony Pictures Releasing | true | false |
| 3 | 2 | Eat Pray Love | $25,573 | -25.5% | 8 | - | $3,196 | $310,544 | 5 | Sony Pictures Releasing | false | false |
| 4 | 3 | Step Up 3D | $13,526 | -26.4% | 6 | - | $2,254 | $198,171 | 5 | N/A | false | false |
| 5 | 4 | Dinner for Schmucks | $9,910 | -35% | 8 | - | $1,238 | $142,333 | 6 | United International Pictures | false | false |
| 6 | - | Chatroom | $8,167 | - | 6 | - | $1,361 | $9,920 | 1 | N/A | true | false |
| 7 | 5 | The Sorcerer's Apprentice | $7,404 | -39.6% | 10 | - | $740 | $131,427 | 6 | Walt Disney Pictures | false | false |
| 8 | 6 | The Switch | $5,079 | -32.5% | 3 | - | $1,693 | $25,789 | 3 | N/A | false | false |
| 9 | 7 | Going the Distance | $4,441 | +4.6% | 7 | - | $634 | $80,575 | 7 | Warner Bros. | false | false |
| 10 | 9 | Legend of the Guardians: The Owls of Ga'Hoole | $3,704 | -2.7% | 11 | - | $336 | $39,166 | 4 | Warner Bros. | false | false |
| 11 | 8 | Scott Pilgrim vs. the World | $1,876 | -51.1% | 6 | - | $312 | $20,495 | 4 | United International Pictures | false | false |
| 12 | 11 | The Crazies | $1,615 | -34.7% | 2 | - | $807 | $17,928 | 5 | N/A | false | false |
