Domestic 2010 Weekend 41
October 8-11, 2010 - Indigenous Peoples' Day Weekend
Key:New This Week
| Rank | LW | Release | Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | - | The Social Network | $17,640,079 | - | 2,771 | - | $6,365 | $48,209,249 | 2 | Sony Pictures Releasing |
| 2 | - | Life as We Know It | $16,211,823 | - | 3,150 | - | $5,146 | $16,211,823 | 1 | Warner Bros. |
| 3 | - | Secretariat | $14,576,278 | - | 3,072 | - | $4,744 | $14,576,278 | 1 | Walt Disney Studios Motion Pictures |
| 4 | - | Legend of the Guardians: The Owls of Ga'Hoole | $8,158,927 | - | 3,225 | - | $2,529 | $40,544,892 | 3 | Warner Bros. |
| 5 | - | My Soul to Take | $7,497,630 | - | 2,572 | - | $2,915 | $7,497,630 | 1 | Universal Pictures |
| 6 | - | The Town | $7,361,369 | - | 2,720 | - | $2,706 | $74,797,888 | 4 | Warner Bros. |
| 7 | - | Wall Street: Money Never Sleeps | $5,208,414 | - | 2,829 | - | $1,841 | $44,249,992 | 3 | Twentieth Century Fox |
| 8 | - | Easy A | $4,852,158 | - | 2,847 | - | $1,704 | $48,790,941 | 4 | Screen Gems |
| 9 | - | Case 39 | $3,030,534 | - | 2,212 | - | $1,370 | $10,000,234 | 2 | Paramount Vantage |
| 10 | - | You Again | $2,876,675 | - | 2,332 | - | $1,233 | $21,133,888 | 3 | Walt Disney Studios Motion Pictures |
| 11 | - | Let Me In | $2,802,586 | - | 2,042 | - | $1,372 | $9,526,387 | 2 | Overture Films |
| 12 | - | It's Kind of a Funny Story | $2,277,620 | - | 742 | - | $3,069 | $2,277,620 | 1 | Focus Features |
| 13 | - | Devil | $2,018,785 | - | 1,442 | - | $1,399 | $30,255,620 | 4 | Universal Pictures |
| 14 | - | Alpha and Omega | $1,910,953 | - | 1,616 | - | $1,182 | $21,428,627 | 4 | Lionsgate Films |
| 15 | - | Resident Evil: Afterlife | $1,428,715 | - | 1,012 | - | $1,411 | $59,040,441 | 5 | Screen Gems |
| 16 | - | Waiting for Superman | $762,567 | - | 103 | - | $7,403 | $1,537,518 | 3 | Paramount Vantage |
| 17 | - | Inception | $568,790 | - | 403 | - | $1,411 | $289,260,086 | 13 | Warner Bros. |
| 18 | - | Catfish | $457,438 | - | 143 | - | $3,198 | $2,300,189 | 4 | Rogue Pictures |
| 19 | - | Takers | $438,550 | - | 412 | - | $1,064 | $56,823,331 | 7 | Screen Gems |
| 20 | - | Despicable Me | $414,775 | - | 353 | - | $1,175 | $246,624,525 | 14 | Universal Pictures |
| 21 | - | Never Let Me Go | $402,803 | - | 167 | - | $2,411 | $1,206,766 | 4 | - |
| 22 | - | Buried | $264,197 | - | 92 | - | $2,871 | $553,541 | 3 | Lionsgate Films |
| 23 | - | Salt | $236,285 | - | 266 | - | $888 | $117,923,111 | 12 | Sony Pictures Releasing |
| 24 | - | Hubble | $212,276 | - | 60 | - | $3,537 | $16,494,206 | 30 | Warner Bros. |
| 25 | - | The Other Guys | $194,727 | - | 289 | - | $673 | $118,020,516 | 10 | Sony Pictures Releasing |
| 26 | - | Nanny McPhee Returns | $179,625 | - | 318 | - | $564 | $28,755,660 | 8 | Universal Pictures |
| 27 | - | Lottery Ticket | $161,485 | - | 194 | - | $832 | $24,469,373 | 8 | Warner Bros. |
| 28 | - | The Expendables | $141,918 | - | 225 | - | $630 | $102,752,519 | 9 | Lionsgate Films |
| 29 | - | Eat Pray Love | $140,050 | - | 215 | - | $651 | $80,006,996 | 9 | Sony Pictures Releasing |
| 30 | - | Vampires Suck | $114,077 | - | 190 | - | $600 | $36,525,627 | 8 | Twentieth Century Fox |
| 31 | - | Dinner for Schmucks | $113,629 | - | 159 | - | $714 | $72,993,255 | 11 | DreamWorks |
| 32 | - | Machete | $113,230 | - | 167 | - | $678 | $26,402,220 | 6 | Twentieth Century Fox |
| 33 | - | Grown Ups | $106,910 | - | 159 | - | $672 | $161,801,268 | 16 | Sony Pictures Releasing |
| 34 | - | The American | $98,499 | - | 174 | - | $566 | $35,388,595 | 6 | Focus Features |
| 35 | - | Stone | $86,584 | - | 6 | - | $14,430 | $86,584 | 1 | Overture Films |
| 36 | - | Going the Distance | $75,228 | - | 196 | - | $383 | $17,757,777 | 6 | Warner Bros. |
| 37 | - | Jack Goes Boating | $64,564 | - | 90 | - | $717 | $380,654 | 4 | Overture Films |
| 38 | - | Cats & Dogs: The Revenge of Kitty Galore | $64,421 | - | 119 | - | $541 | $43,526,053 | 11 | Warner Bros. |
| 39 | - | Under the Sea 3D | $63,779 | - | 18 | - | $3,543 | $24,423,218 | 87 | Warner Bros. |
| 40 | - | Ramona and Beezus | $59,554 | - | 106 | - | $561 | $26,049,930 | 12 | Twentieth Century Fox |
| 41 | - | Nowhere Boy | $59,167 | - | 4 | - | $14,791 | $59,167 | 1 | The Weinstein Company |
| 42 | - | The Twilight Saga: Eclipse | $43,645 | - | 83 | - | $525 | $300,482,411 | 15 | Summit Entertainment |
| 43 | - | I Spit on Your Grave | $37,635 | - | 12 | - | $3,136 | $37,635 | 1 | Anchor Bay Films |
| 44 | - | Piranha 3D | $33,219 | - | 54 | - | $615 | $24,954,225 | 8 | - |
| 45 | - | Winter's Bone | $25,151 | - | 57 | - | $441 | $6,170,045 | 18 | Roadside Attractions |
| 46 | - | The Kids Are All Right | $22,295 | - | 31 | - | $719 | $20,777,816 | 14 | Focus Features |
| 47 | - | The Tillman Story | $20,898 | - | 24 | - | $870 | $670,212 | 8 | The Weinstein Company |
| 48 | - | Avatar 2010 Special Edition | $19,942 | - | 14 | - | $1,424 | $10,544,093 | 7 | Twentieth Century Fox |
| 49 | - | The Concert | $9,069 | - | 10 | - | $906 | $632,717 | 11 | The Weinstein Company |
| 50 | - | Flipped | $7,592 | - | 18 | - | $421 | $1,752,866 | 10 | Warner Bros. |
| 51 | - | Undertow | $1,847 | - | 1 | - | $1,847 | $19,953 | 4 | The Film Collaborative |
| 52 | - | The Disappearance of Alice Creed | $1,722 | - | 2 | - | $861 | $164,495 | 10 | Anchor Bay Films |
