| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Eat Pray Love | $42,893 | -28.2% | 7 | - | $6,127 | $123,661 | 2 | Sony Pictures Releasing | false | false |
| 2 | 3 | Despicable Me | $35,392 | -18.3% | 8 | - | $4,424 | $226,305 | 4 | United International Pictures | false | false |
| 3 | 2 | Resident Evil: Afterlife | $25,569 | -44.4% | 7 | -1 | $3,652 | $176,375 | 3 | Jaguar Film International Distribution | false | false |
| 4 | - | Legend of the Guardians: The Owls of Ga'Hoole | $17,221 | - | 8 | - | $2,152 | $17,221 | 1 | Warner Bros. | true | false |
| 5 | - | Centurion | $14,400 | - | 5 | - | $2,880 | $14,400 | 1 | N/A | true | false |
| 6 | 4 | Step Up 3D | $13,323 | -46.4% | 6 | - | $2,220 | $505,014 | 6 | Jaguar Film International Distribution | false | false |
| 7 | 5 | Going the Distance | $12,058 | -20.9% | 5 | -1 | $2,411 | $57,184 | 3 | Warner Bros. | false | false |
| 8 | 8 | Wall Street: Money Never Sleeps | $9,495 | -14.2% | 5 | - | $1,899 | $85,502 | 4 | 20th Century Fox International | false | false |
| 9 | 9 | The Other Guys | $9,250 | -8% | 4 | -1 | $2,312 | $107,329 | 5 | Sony Pictures Releasing | false | false |
| 10 | 6 | The American | $7,584 | -40.8% | 5 | -2 | $1,516 | $45,200 | 3 | Italian International Film | false | false |
| 11 | - | Cyrus | $5,547 | - | 3 | - | $1,849 | $5,547 | 1 | 20th Century Fox International | true | false |
| 12 | 10 | Dinner for Schmucks | $2,958 | -55% | 3 | - | $986 | $107,630 | 5 | United International Pictures | false | false |
| 13 | 15 | Piranha 3D | $2,287 | +76.7% | 3 | - | $762 | $201,541 | 6 | Italian International Film | false | false |
| 14 | 12 | You Again | $2,005 | -43.9% | 3 | -1 | $668 | $30,374 | 4 | Walt Disney Pictures | false | false |
| 15 | - | 12 Angry Lebanese: The Documentary | $1,981 | - | 2 | - | $990 | $24,745 | 7 | N/A | false | false |
| 16 | 14 | Knight and Day 2010 Re-release | $1,971 | -1.6% | 2 | - | $985 | $269,726 | 16 | 20th Century Fox International | false | false |
| 17 | 11 | The Expendables | $1,220 | -81% | 3 | -2 | $406 | $181,363 | 6 | N/A | false | false |
| 18 | 16 | Everyday Is a Holiday | $1,038 | -11.4% | 2 | - | $519 | $7,225 | 3 | N/A | false | false |
| 19 | 13 | The Descent: Part 2 | $1,022 | -70.6% | 3 | -1 | $340 | $5,290 | 2 | N/A | false | false |
| 20 | 7 | Scott Pilgrim vs. the World | $897 | -92% | 2 | -3 | $448 | $14,670 | 2 | United International Pictures | false | false |
| 21 | 20 | Cats & Dogs: The Revenge of Kitty Galore | $688 | +14.7% | 1 | - | $688 | $107,846 | 6 | Warner Bros. | false | false |
| 22 | 19 | Inception | $686 | +3% | 1 | - | $686 | $556,318 | 12 | Warner Bros. | false | false |
| 23 | 17 | The Sorcerer's Apprentice | $372 | -68% | 1 | -1 | $372 | $191,358 | 14 | Walt Disney Pictures | false | false |
| 24 | 21 | Lembi 8 Giga | $320 | -40.5% | 1 | - | $320 | $213,630 | 13 | N/A | false | false |
| 25 | 18 | Partir | $260 | -63.6% | 1 | -2 | $260 | $15,215 | 7 | Italian International Film | false | false |
| 26 | - | What's Going On? | $104 | - | 2 | - | $52 | $558 | 2 | Italian International Film | false | false |
