| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Wall Street: Money Never Sleeps | $2,849,151 | - | 444 | - | $6,417 | $2,849,151 | 1 | 20th Century Fox International | true | false |
| 2 | - | Life as We Know It | $1,573,720 | - | 395 | - | $3,984 | $1,573,720 | 1 | Warner Bros. | true | false |
| 3 | - | Charlie St. Cloud | $1,027,318 | - | 376 | - | $2,732 | $1,027,318 | 1 | Universal Pictures International (UPI) | true | false |
| 4 | 1 | The Other Guys | $1,017,185 | -34.2% | 400 | -27 | $2,542 | $11,387,647 | 4 | Sony Pictures Releasing | false | false |
| 5 | 2 | The Town | $930,848 | -33.9% | 326 | +3 | $2,855 | $5,985,471 | 3 | Warner Bros. | false | false |
| 6 | 5 | The Hole | $809,973 | -27% | 325 | -34 | $2,492 | $4,104,810 | 3 | N/A | false | false |
| 7 | 6 | Made in Dagenham | $809,825 | -24.1% | 357 | +3 | $2,268 | $2,859,723 | 2 | Paramount Pictures International | false | false |
| 8 | 4 | Eat Pray Love | $645,000 | -49.1% | 388 | -41 | $1,662 | $6,116,464 | 3 | Sony Pictures Releasing | false | false |
| 9 | 3 | Buried | $522,192 | -59.8% | 283 | -19 | $1,845 | $2,479,092 | 2 | Icon Film Distribution | false | false |
| 10 | 8 | Toy Story 3 | $417,333 | -36.3% | 399 | +19 | $1,045 | $116,989,068 | 12 | Walt Disney Pictures | false | false |
| 11 | - | Mr. Nice | $382,978 | - | 102 | - | $3,754 | $382,978 | 1 | Entertainment One | true | false |
| 12 | 12 | Marmaduke | $327,233 | -25.7% | 367 | -28 | $891 | $8,529,109 | 8 | 20th Century Fox International | false | false |
| 13 | 7 | Back to the Future Part II 2010 Re-release | $311,934 | -57.3% | 262 | -11 | $1,190 | $1,464,772 | 2 | Universal Pictures International (UPI) | false | false |
| 14 | 13 | Diary of a Wimpy Kid | $233,847 | -29.4% | 315 | -24 | $742 | $4,283,601 | 7 | 20th Century Fox International | false | false |
| 15 | 10 | Grown Ups | $220,381 | -53.9% | 180 | -93 | $1,224 | $12,161,427 | 7 | Sony Pictures Releasing | false | false |
| 16 | 9 | Devil | $218,559 | -58.5% | 176 | -149 | $1,241 | $4,477,471 | 4 | Universal Pictures International (UPI) | false | false |
| 17 | 11 | Enthiran | $172,555 | -63.1% | 34 | +4 | $5,075 | $785,837 | 2 | Ayngaran International | false | false |
| 18 | 14 | Takers 2010 Re-release | $150,388 | -54.4% | 117 | -34 | $1,285 | $686,142 | 2 | Sony Pictures Releasing | false | false |
| 19 | 15 | Anjaana Anjaani | $136,212 | -53.2% | 54 | - | $2,522 | $577,786 | 2 | Eros Worldwide | false | false |
| 20 | - | Resident Evil: Afterlife | $116,281 | - | 73 | - | $1,592 | $7,492,098 | 5 | Sony Pictures Releasing | false | false |
| 21 | - | Inception | $100,744 | - | 49 | - | $2,056 | $56,878,570 | 13 | Warner Bros. | false | false |
| 22 | - | Winter's Bone | $62,682 | - | 35 | - | $1,790 | $947,359 | 4 | Artificial Eye | false | false |
| 23 | - | Tinker Bell and the Great Fairy Rescue | $51,547 | - | 130 | - | $396 | $2,396,006 | 9 | Walt Disney Pictures | false | false |
| 24 | - | Shrek Forever After | $45,464 | - | 125 | - | $363 | $51,462,094 | 15 | Paramount Pictures International | false | false |
| 25 | - | Scott Pilgrim vs. the World | $45,216 | - | 60 | - | $753 | $8,445,713 | 7 | Universal Pictures International (UPI) | false | false |
| 26 | - | Tamara Drewe | $36,496 | - | 53 | - | $688 | $3,967,673 | 5 | Momentum Pictures | false | false |
| 27 | - | Avatar | $33,694 | - | 6 | - | $5,615 | $150,025,197 | 43 | 20th Century Fox International | false | false |
| 28 | - | The Karate Kid | $33,159 | - | 91 | - | $364 | $19,762,070 | 11 | Sony Pictures Releasing | false | false |
| 29 | - | Crook: It's Good to Be Bad | $27,345 | - | 15 | - | $1,823 | $27,345 | 1 | - | true | false |
| 30 | - | A Town Called Panic | $26,312 | - | 15 | - | $1,754 | $26,312 | 1 | Optimum Releasing | true | false |
| 31 | - | Cats & Dogs: The Revenge of Kitty Galore | $22,234 | - | 240 | - | $92 | $7,449,966 | 10 | Warner Bros. | false | false |
| 32 | - | Salt | $18,050 | - | 28 | - | $644 | $11,321,253 | 8 | Sony Pictures Releasing | false | false |
| 33 | - | Dabangg | $14,726 | - | 14 | - | $1,051 | $1,247,468 | 5 | Eros Worldwide | false | false |
| 34 | - | Restrepo | $14,710 | - | 6 | - | $2,451 | $14,710 | 1 | Periscoop Film | true | false |
| 35 | - | The Girl Who Played with Fire | $14,025 | - | 15 | - | $935 | $2,486,775 | 7 | Momentum Pictures | false | false |
| 36 | - | Cyrus | $12,940 | - | 19 | - | $681 | $1,936,218 | 5 | 20th Century Fox International | false | false |
| 37 | - | The Illusionist | $11,727 | - | 12 | - | $977 | $1,316,848 | 8 | Warner Bros. | false | false |
| 38 | - | Enter the Void | $11,443 | - | 9 | - | $1,271 | $137,307 | 3 | Trinity Filmed Entertainment | false | false |
| 39 | - | The Last Exorcism | $11,192 | - | 37 | - | $302 | $5,874,380 | 6 | Optimum Releasing | false | false |
| 40 | - | The Secret in Their Eyes | $10,226 | - | 9 | - | $1,136 | $1,166,844 | 9 | - | false | false |
| 41 | - | Police, Adjective | $9,871 | - | 10 | - | $987 | $38,268 | 2 | Artificial Eye | false | false |
| 42 | - | The Sorcerer's Apprentice | $9,867 | - | 28 | - | $352 | $5,423,182 | 9 | Walt Disney Pictures | false | false |
| 43 | - | Going the Distance | $8,814 | - | 15 | - | $587 | $2,124,322 | 5 | Warner Bros. | false | false |
| 44 | - | Certified Copy | $7,530 | - | 6 | - | $1,255 | $497,860 | 6 | Artificial Eye | false | false |
| 45 | - | Jackboots on Whitehall | $7,526 | - | 31 | - | $242 | $7,526 | 1 | Vertigo Films | true | false |
| 46 | - | Dinner for Schmucks | $7,217 | - | 16 | - | $451 | $4,040,902 | 6 | Paramount Pictures International | false | false |
| 47 | - | The Expendables | $6,042 | - | 16 | - | $377 | $15,969,695 | 8 | Lionsgate Films | false | false |
| 48 | - | I'm Still Here | $5,638 | - | 5 | - | $1,127 | $98,671 | 4 | Optimum Releasing | false | false |
| 49 | - | Peepli Live | $5,635 | - | 9 | - | $626 | $136,106 | 3 | Artificial Eye | false | false |
