| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Elite Squad 2: The Enemy Within | $7,882,884 | - | 710 | - | $11,102 | $7,882,884 | 1 | N/A | true | false |
| 5 | 4 | Astral City: A Spiritual Journey | $517,044 | -53.2% | 340 | -57 | $1,520 | $19,616,132 | 6 | 20th Century Fox International | false | false |
| 2 | - | Legend of the Guardians: The Owls of Ga'Hoole | $1,531,875 | - | 289 | - | $5,300 | $1,531,875 | 1 | Warner Bros. | true | false |
| 3 | 1 | Eat Pray Love | $1,403,572 | -32.4% | 236 | - | $5,947 | $4,409,992 | 2 | Sony Pictures Releasing | false | false |
| 14 | 10 | Despicable Me | $47,389 | -57.6% | 180 | -14 | $263 | $13,524,706 | 10 | Universal Pictures International (UPI) | false | false |
| 4 | 3 | Grown Ups | $816,051 | -32.3% | 175 | -3 | $4,663 | $4,228,632 | 3 | Sony Pictures Releasing | false | false |
| 7 | 2 | Resident Evil: Afterlife | $239,669 | -81.6% | 142 | -246 | $1,687 | $8,865,830 | 4 | Sony Pictures Releasing | false | false |
| 9 | 7 | The Last Exorcism | $147,043 | -68.8% | 132 | -48 | $1,113 | $1,798,825 | 3 | PlayArte Pictures | false | false |
| 6 | 5 | Vampires Suck | $347,498 | -48.8% | 131 | +4 | $2,652 | $1,285,312 | 2 | 20th Century Fox International | false | false |
| 8 | 6 | Wall Street: Money Never Sleeps | $225,484 | -58.9% | 100 | -56 | $2,254 | $2,026,204 | 3 | 20th Century Fox International | false | false |
| 12 | 9 | The Karate Kid | $48,276 | -79.4% | 89 | -93 | $542 | $10,022,337 | 7 | Sony Pictures Releasing | false | false |
| 15 | 12 | The Last Airbender | $30,392 | -56.6% | 88 | -13 | $345 | $9,428,488 | 8 | Paramount Pictures International | false | false |
| 10 | - | Me and My Umbrella | $83,412 | - | 79 | - | $1,055 | $83,412 | 1 | 20th Century Fox International | true | false |
| 19 | 25 | Toy Story 3 | $12,462 | +49.4% | 66 | +6 | $188 | $24,988,997 | 17 | Walt Disney Pictures | false | false |
| 17 | 14 | Cats & Dogs: The Revenge of Kitty Galore | $16,718 | -44.9% | 47 | -5 | $355 | $3,582,553 | 6 | Warner Bros. | false | false |
| 16 | 11 | Nanny McPhee Returns | $29,707 | -72.8% | 39 | -8 | $761 | $639,533 | 4 | Universal Pictures International (UPI) | false | false |
| 11 | 8 | The Switch | $59,058 | -76.1% | 33 | -34 | $1,789 | $1,734,774 | 4 | N/A | false | false |
| 20 | 17 | The Sorcerer's Apprentice | $10,397 | -58.3% | 24 | -33 | $433 | $4,986,412 | 9 | Walt Disney Pictures | false | false |
| 18 | 13 | Going the Distance | $14,756 | -73.9% | 20 | -39 | $737 | $1,545,373 | 5 | Warner Bros. | false | false |
| 13 | - | Brother and Sister | $48,035 | - | 13 | - | $3,695 | $48,035 | 1 | N/A | true | false |
| 22 | 20 | Solomon Kane | $5,021 | -71.2% | 12 | -16 | $418 | $613,728 | 5 | Paris Filmes | false | false |
| 25 | 18 | Killers | $2,251 | -90.1% | 12 | -32 | $187 | $2,510,111 | 7 | N/A | false | false |
| 23 | 16 | The Expendables | $3,181 | -88.6% | 10 | -30 | $318 | $5,655,193 | 9 | N/A | false | false |
| 26 | 22 | The Well Beloved One | $1,880 | -83.4% | 10 | -23 | $188 | $4,948,115 | 12 | Walt Disney Pictures | false | false |
| 27 | 19 | 5 x Favela, Now by Ourselves | $1,367 | -93.6% | 10 | -19 | $136 | $760,822 | 7 | Sony Pictures Releasing | false | false |
| 21 | 15 | Inception | $8,525 | -69.9% | 8 | -22 | $1,065 | $10,300,115 | 10 | Warner Bros. | false | false |
| 28 | 21 | Hot Tub Time Machine | $475 | -97.2% | 3 | -19 | $158 | $626,028 | 5 | N/A | false | false |
| 24 | 26 | Salt | $2,681 | -56.3% | 2 | -3 | $1,340 | $7,383,489 | 11 | Sony Pictures Releasing | false | false |
| 29 | 27 | The Imaginarium of Doctor Parnassus | $407 | +37% | 2 | +1 | $203 | $161,625 | 23 | Sony Pictures Releasing | false | false |
| 30 | 28 | A Prophet | $138 | +263.2% | 1 | -2 | $138 | $161,422 | 17 | Sony Pictures Releasing | false | false |
