| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Legend of the Guardians: The Owls of Ga'Hoole | $448,993 | -27.9% | 162 | +2 | $2,771 | $1,215,861 | 2 | Warner Bros. | false | false |
| 2 | 3 | Eat Pray Love | $125,627 | -6.1% | 25 | - | $5,025 | $319,577 | 2 | Sony Pictures Releasing | false | false |
| 3 | - | Avatar 2010 Special Edition | $121,125 | - | 46 | - | $2,633 | $14,670,044 | 1 | 20th Century Fox International | true | false |
| 4 | 2 | Resident Evil: Afterlife | $118,145 | -47.5% | 68 | -21 | $1,737 | $2,923,762 | 5 | Sony Pictures Releasing | false | false |
| 5 | - | Tinker Bell and the Great Fairy Rescue | $98,525 | - | 41 | - | $2,403 | $98,525 | 1 | Walt Disney Pictures | true | false |
| 6 | 5 | Wall Street: Money Never Sleeps | $70,674 | -19.6% | 40 | +3 | $1,766 | $349,318 | 3 | 20th Century Fox International | false | false |
| 7 | 6 | Inception | $47,105 | -16% | 27 | -3 | $1,744 | $3,104,517 | 10 | Warner Bros. | false | false |
| 8 | 4 | The Last Airbender | $39,885 | -61.2% | 55 | -23 | $725 | $3,400,669 | 7 | United International Pictures | false | false |
| 9 | 7 | Going the Distance | $26,537 | -28.9% | 22 | -5 | $1,206 | $282,898 | 4 | Warner Bros. | false | false |
| 10 | 9 | From Paris with Love | $20,305 | -2% | 22 | +1 | $922 | $130,164 | 4 | - | false | false |
| 11 | 12 | Vampires Suck | $19,549 | +51.7% | 13 | +4 | $1,503 | $184,778 | 6 | 20th Century Fox International | false | false |
| 12 | 8 | Cats & Dogs: The Revenge of Kitty Galore | $18,470 | -24.8% | 32 | -2 | $577 | $2,073,582 | 9 | Warner Bros. | false | false |
| 13 | - | Micmacs | $12,037 | - | 10 | - | $1,203 | $12,037 | 1 | Sony Pictures Releasing | true | false |
| 14 | 11 | Despicable Me | $10,221 | -23.5% | 26 | -7 | $393 | $2,766,880 | 11 | Universal Pictures International (UPI) | false | false |
| 15 | 10 | Grown Ups | $8,782 | -43.5% | 11 | -3 | $798 | $955,248 | 10 | Sony Pictures Releasing | false | false |
| 16 | 13 | Oceans | $4,304 | -50.6% | 16 | -6 | $269 | $541,311 | 8 | Cine Colombia | false | false |
| 17 | 20 | Halloween II | $4,051 | +506.4% | 3 | +2 | $1,350 | $111,312 | 7 | Cine Colombia | false | false |
| 18 | 17 | Daybreakers | $3,957 | +14.2% | 5 | - | $791 | $119,053 | 6 | Venus | false | false |
| 19 | 15 | City of Life and Death | $3,147 | -18.1% | 2 | -1 | $1,573 | $8,986 | 2 | Cineplex | false | false |
| 20 | 18 | The Box | $2,527 | -14.1% | 3 | -4 | $842 | $71,459 | 4 | Cine Colombia | false | false |
| 21 | 14 | Green Zone 2010 Re-release | $1,441 | -75.7% | 2 | -2 | $720 | $131,978 | 8 | United International Pictures | false | false |
| 22 | 16 | The Burning Plain | $1,389 | -63% | 3 | -1 | $463 | $54,487 | 4 | Cine Colombia | false | false |
| 23 | 19 | Shrek Forever After | $1,190 | -47.5% | 5 | -6 | $238 | $6,839,803 | 14 | United International Pictures | false | false |
