| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Eat Pray Love | $408,496 | - | 40 | - | $10,212 | $447,114 | 1 | Sony Pictures Releasing | true | false |
| 2 | - | Vampires Suck | $291,608 | - | 41 | - | $7,112 | $291,608 | 1 | 20th Century Fox International | true | false |
| 3 | 1 | Resident Evil: Afterlife | $209,227 | -35.7% | 35 | - | $5,977 | $581,765 | 2 | Belga Films | false | false |
| 4 | 3 | The Town | $177,879 | -19.7% | 25 | - | $7,115 | $539,376 | 2 | Warner Bros. | false | false |
| 5 | 2 | Wall Street: Money Never Sleeps | $169,094 | -28.7% | 43 | - | $3,932 | $845,081 | 3 | 20th Century Fox International | false | false |
| 6 | 6 | Inception | $82,485 | -21.9% | 39 | -30 | $2,115 | $5,856,951 | 12 | Warner Bros. | false | false |
| 7 | 5 | Grown Ups | $75,249 | -29.5% | 25 | -3 | $3,009 | $739,527 | 5 | Sony Pictures Releasing | false | false |
| 8 | 7 | Oxygen | $74,389 | -22.8% | 23 | - | $3,234 | $638,932 | 5 | Kinepolis Film Distribution (KFD) | false | false |
| 9 | 4 | Of Gods and Men | $67,588 | -37.6% | 22 | -2 | $3,072 | $706,085 | 5 | Benelux Film Distributors | false | false |
| 10 | 12 | Turquaze | $55,612 | -12% | 9 | - | $6,179 | $137,503 | 2 | Kinepolis Film Distribution (KFD) | false | false |
| 11 | 9 | Piranha 3D | $46,889 | -40.9% | 22 | -7 | $2,131 | $1,028,202 | 6 | Kinepolis Film Distribution (KFD) | false | false |
| 12 | 8 | The Expendables | $42,242 | -52.8% | 37 | -3 | $1,141 | $2,597,185 | 8 | Benelux Film Distributors | false | false |
| 13 | 14 | Marmaduke | $41,341 | -32.4% | 41 | -4 | $1,008 | $1,126,810 | 8 | 20th Century Fox International | false | false |
| 14 | 16 | I Am Love | $40,388 | -18.6% | 10 | - | $4,038 | $130,350 | 2 | Cinéart | false | false |
| 15 | 11 | A Turtle's Tale: Sammy's Adventures | $38,824 | -46.5% | 45 | -6 | $862 | $1,925,741 | 10 | Kinepolis Film Distribution (KFD) | false | false |
| 16 | 10 | Dinner for Schmucks | $33,096 | -55% | 21 | - | $1,576 | $203,525 | 2 | Universal Pictures International (UPI) | false | false |
| 17 | 15 | The Sorcerer's Apprentice | $30,965 | -45.6% | 30 | -8 | $1,032 | $2,020,773 | 9 | Walt Disney Pictures | false | false |
| 18 | 17 | Outside the Law | $29,389 | -40.1% | 20 | -1 | $1,469 | $107,803 | 2 | N/A | false | false |
| 19 | 13 | Step Up 3D | $28,659 | -54.5% | 27 | -17 | $1,061 | $3,493,546 | 10 | Belga Films | false | false |
| 20 | 18 | Tamara Drewe | $27,490 | -24.3% | 13 | +1 | $2,114 | $235,821 | 4 | Cinéart | false | false |
| 21 | 19 | The Last Exorcism | $21,922 | -37.5% | 10 | -1 | $2,192 | $231,205 | 4 | Cinéart | false | false |
| 22 | - | Illégal | $20,909 | - | 14 | - | $1,493 | $27,310 | 1 | N/A | true | false |
| 23 | 22 | The Switch | $14,264 | -43% | 11 | -9 | $1,296 | $666,251 | 7 | Paradiso Entertainment | false | false |
| 24 | 21 | Toy Story 3 | $13,365 | -50.3% | 25 | -1 | $534 | $5,436,016 | 16 | Walt Disney Pictures | false | false |
| 25 | - | Heartbeats | $13,067 | - | 9 | - | $1,451 | $14,570 | 1 | ABC Distribution | true | false |
| 26 | 25 | Shrek Forever After | $12,924 | -42.8% | 26 | -7 | $497 | $4,879,442 | 13 | Universal Pictures International (UPI) | false | false |
| 27 | 24 | Salt | $12,878 | -43.9% | 10 | -8 | $1,287 | $1,742,087 | 10 | Sony Pictures Releasing | false | false |
| 28 | 20 | Twelve | $11,835 | -65.1% | 11 | -4 | $1,075 | $146,011 | 3 | Benelux Film Distributors | false | false |
| 29 | 26 | Cats & Dogs: The Revenge of Kitty Galore | $10,678 | -51.2% | 30 | -8 | $355 | $1,422,561 | 10 | Warner Bros. | false | false |
| 30 | - | Special Treatment | $8,974 | - | 4 | - | $2,243 | $10,463 | 1 | Cinéart | true | false |
| 31 | 29 | The Tree | $8,727 | -19.5% | 10 | -2 | $872 | $229,286 | 7 | Cinéart | false | false |
| 32 | 27 | The Last Airbender | $8,255 | -47.5% | 14 | -9 | $589 | $3,243,184 | 11 | Universal Pictures International (UPI) | false | false |
| 33 | 28 | The Karate Kid | $5,474 | -53.9% | 14 | - | $391 | $2,340,396 | 12 | Sony Pictures Releasing | false | false |
| 34 | 31 | Tinker Bell and the Lost Treasure | $4,249 | -41.4% | 8 | - | $531 | $160,348 | 8 | Walt Disney Pictures | false | false |
| 35 | 23 | Going the Distance | $4,064 | -82.6% | 17 | -5 | $239 | $333,853 | 5 | Warner Bros. | false | false |
| 36 | 38 | Uncle Boonmee Who Can Recall His Past Lives | $3,529 | +18.9% | 6 | - | $588 | $53,407 | 6 | N/A | false | false |
| 37 | 33 | Benda Bilili! | $3,368 | -41.9% | 4 | - | $842 | $19,244 | 3 | Cinéart | false | false |
| 38 | 34 | The Secret in Their Eyes | $2,498 | -53.9% | 7 | - | $356 | $328,946 | 18 | N/A | false | false |
| 39 | 36 | Solutions locales pour un désordre global | $2,327 | -34.6% | 5 | -1 | $465 | $49,758 | 5 | N/A | false | false |
| 40 | - | Donnant donnant | $2,117 | - | 13 | - | $162 | $2,117 | 1 | N/A | true | false |
| 41 | 32 | The Killer Inside Me | $1,465 | -77.3% | 4 | -5 | $366 | $172,968 | 8 | Paradiso Entertainment | false | false |
| 42 | 30 | Four Lovers | $1,375 | -83.7% | 6 | -1 | $229 | $30,496 | 3 | Benelux Film Distributors | false | false |
| 43 | 37 | Letters to Juliet | $958 | -68.5% | 10 | -2 | $95 | $354,429 | 7 | Belga Films | false | false |
| 44 | 41 | The Disappearance of Alice Creed | $787 | -61.2% | 6 | +1 | $131 | $67,226 | 4 | Benelux Film Distributors | false | false |
| 45 | 40 | Single by Contract | $723 | -74.8% | 4 | - | $180 | $14,854 | 4 | N/A | false | false |
| 46 | 46 | Furry Vengeance | $706 | -47% | 3 | - | $235 | $203,540 | 12 | Belga Films | false | false |
| 47 | 43 | Love Crime | $701 | -53.9% | 8 | -2 | $87 | $166,930 | 8 | Benelux Film Distributors | false | false |
| 48 | 47 | The Ghost Writer | $488 | -38.5% | 4 | +2 | $122 | $922,230 | 29 | Benelux Film Distributors | false | false |
| 49 | 42 | The Twilight Saga: Eclipse | $419 | -72.7% | 4 | -2 | $104 | $6,741,763 | 15 | Belga Films | false | false |
| 50 | 48 | The Runaways | $400 | -7% | 2 | - | $200 | $23,398 | 4 | Belga Films | false | false |
| 51 | 44 | Women Without Men | $145 | -90.2% | 1 | -1 | $145 | $24,395 | 6 | Benelux Film Distributors | false | false |
