| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Legend of the Guardians: The Owls of Ga'Hoole | $273,728 | - | 72 | - | $3,801 | $273,728 | 1 | Warner Bros. | true | false |
| 2 | - | The Other Guys | $153,361 | - | 45 | - | $3,408 | $153,361 | 1 | Sony Pictures Releasing | true | false |
| 3 | 1 | Resident Evil: Afterlife | $115,485 | -65.5% | 96 | -2 | $1,202 | $1,556,447 | 3 | Sony Pictures Releasing | false | false |
| 4 | - | Wall Street: Money Never Sleeps | $113,058 | - | 33 | - | $3,426 | $113,058 | 1 | 20th Century Fox International | true | false |
| 5 | 2 | The Edge | $71,284 | -3.1% | 45 | - | $1,584 | $183,273 | 2 | N/A | false | false |
| 6 | 5 | Going the Distance | $23,106 | -36% | 42 | -2 | $550 | $292,834 | 4 | Warner Bros. | false | false |
| 7 | 4 | Sea Rex 3D: Journey to a Prehistoric World | $18,532 | -55.6% | 32 | - | $579 | $68,667 | 2 | N/A | false | false |
| 8 | 3 | Alpha and Omega | $8,630 | -81.3% | 13 | -32 | $663 | $145,494 | 3 | N/A | false | false |
| 9 | 7 | A Yakuza's Daughter Never Cries | $7,309 | -59.7% | 17 | - | $429 | $56,622 | 2 | N/A | false | false |
| 10 | 9 | The Joneses | $7,032 | -29.9% | 6 | -5 | $1,172 | $78,614 | 5 | N/A | false | false |
| 11 | 8 | Inception | $5,186 | -59.5% | 7 | -6 | $740 | $1,472,881 | 11 | Warner Bros. | false | false |
| 12 | 11 | Avatar | $3,842 | -3.9% | 3 | - | $1,280 | $8,418,865 | 42 | 20th Century Fox International | false | false |
| 13 | 15 | Grown Ups | $1,227 | +34.8% | 3 | -6 | $409 | $701,606 | 9 | Sony Pictures Releasing | false | false |
| 14 | 12 | The Karate Kid | $1,003 | -33.1% | 9 | -13 | $111 | $317,394 | 7 | Sony Pictures Releasing | false | false |
| 15 | 14 | Cats & Dogs: The Revenge of Kitty Galore | $952 | -16.2% | 2 | -1 | $476 | $514,586 | 10 | Warner Bros. | false | false |
| 16 | 19 | Toy Story 3 | $531 | -16.9% | 3 | -1 | $177 | $664,428 | 15 | Walt Disney Pictures | false | false |
| 17 | 18 | Despicable Me | $303 | -56.3% | 2 | - | $151 | $1,094,387 | 12 | Universal Pictures International (UPI) | false | false |
| 18 | 17 | Step Up 3D | $302 | -61% | 1 | -1 | $302 | $481,097 | 8 | N/A | false | false |
| 19 | 13 | Tinker Bell and the Great Fairy Rescue | $257 | -81.5% | 4 | -4 | $64 | $82,610 | 8 | Walt Disney Pictures | false | false |
| 20 | 16 | Shrek Forever After | $119 | -86.6% | 1 | - | $119 | $4,007,403 | 20 | Paramount Pictures International | false | false |
| 21 | 22 | Salt | $27 | -90.8% | 1 | -1 | $27 | $1,242,676 | 10 | Sony Pictures Releasing | false | false |
