| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | 1 | Resident Evil: Afterlife | $1,738,570 | -40.2% | 417 | -8 | $4,169 | $5,979,853 | 2 | Sony Pictures Releasing | false | false |
| 2 | 2 | Astral City: A Spiritual Journey | $1,537,321 | -37.6% | 406 | -11 | $3,786 | $16,129,059 | 4 | 20th Century Fox International | false | false |
| 3 | - | Grown Ups | $1,273,954 | - | 175 | - | $7,279 | $1,273,954 | 1 | Sony Pictures Releasing | true | false |
| 4 | - | Wall Street: Money Never Sleeps | $774,959 | - | 154 | - | $5,032 | $774,959 | 1 | 20th Century Fox International | true | false |
| 5 | - | The Last Exorcism | $656,767 | - | 182 | - | $3,608 | $656,767 | 1 | PlayArte Pictures | true | false |
| 6 | 4 | The Switch | $397,089 | -31.3% | 83 | -2 | $4,784 | $1,180,485 | 2 | N/A | false | false |
| 7 | 3 | The Karate Kid | $387,955 | -51.1% | 260 | -90 | $1,492 | $9,494,847 | 5 | Sony Pictures Releasing | false | false |
| 8 | 7 | Despicable Me | $163,633 | -28.4% | 194 | -34 | $843 | $12,834,927 | 8 | Universal Pictures International (UPI) | false | false |
| 9 | 6 | Nanny McPhee Returns | $141,616 | -39.3% | 50 | - | $2,832 | $425,448 | 2 | Universal Pictures International (UPI) | false | false |
| 10 | 5 | Going the Distance | $114,038 | -68.3% | 81 | -38 | $1,407 | $1,363,339 | 3 | Warner Bros. | false | false |
| 11 | 10 | The Last Airbender | $112,057 | -41.2% | 115 | -21 | $974 | $8,945,102 | 6 | Paramount Pictures International | false | false |
| 12 | 8 | Inception | $98,151 | -54.7% | 91 | -46 | $1,078 | $9,885,849 | 8 | Warner Bros. | false | false |
| 13 | 11 | Killers | $56,314 | -61.9% | 71 | -25 | $793 | $2,369,681 | 5 | N/A | false | false |
| 14 | 9 | Cats & Dogs: The Revenge of Kitty Galore | $54,097 | -71.9% | 51 | -63 | $1,060 | $3,392,050 | 4 | Warner Bros. | false | false |
| 15 | 15 | The Sorcerer's Apprentice | $38,096 | -54% | 71 | -46 | $536 | $4,766,777 | 7 | Walt Disney Pictures | false | false |
| 16 | 12 | Hot Tub Time Machine | $35,515 | -75.9% | 28 | -32 | $1,268 | $568,913 | 3 | N/A | false | false |
| 17 | 13 | The Expendables | $33,623 | -67.8% | 60 | -56 | $560 | $5,409,031 | 7 | N/A | false | false |
| 18 | 17 | The Well Beloved One | $25,729 | -55.2% | 54 | -37 | $476 | $4,756,408 | 10 | Walt Disney Pictures | false | false |
| 19 | 18 | Baaria | $24,338 | -40.2% | 10 | - | $2,433 | $80,852 | 2 | Paris Filmes | false | false |
| 20 | 14 | Solomon Kane | $20,793 | -80% | 30 | -35 | $693 | $550,809 | 3 | Paris Filmes | false | false |
| 21 | 16 | 5 x Favela, Now by Ourselves | $19,045 | -67.3% | 23 | -7 | $828 | $712,708 | 5 | Sony Pictures Releasing | false | false |
| 22 | 21 | Little Nicholas | $9,459 | -23.2% | 8 | -3 | $1,182 | $724,494 | 13 | N/A | false | false |
| 23 | 22 | 400 Against 1: A History of Organized Crime | $3,459 | -68.1% | 27 | -13 | $128 | $606,641 | 8 | PlayArte Pictures | false | false |
| 24 | 23 | Salt | $3,416 | -55.3% | 10 | -11 | $341 | $7,371,629 | 9 | Sony Pictures Releasing | false | false |
| 25 | 19 | [Rec]² | $3,353 | -87.2% | 9 | -21 | $372 | $365,392 | 4 | PlayArte Pictures | false | false |
| 26 | 24 | Toy Story 3 | $3,285 | -35.2% | 13 | -7 | $252 | $24,133,557 | 15 | Walt Disney Pictures | false | false |
| 27 | 27 | The Back-up Plan | $1,410 | -19.8% | 2 | -1 | $705 | $3,377,721 | 16 | Sony Pictures Releasing | false | false |
| 28 | 25 | The Last Song | $508 | -76.4% | 3 | -2 | $169 | $107,330 | 16 | Walt Disney Pictures | false | false |
| 29 | 28 | The Imaginarium of Doctor Parnassus | $440 | -45.5% | 1 | -3 | $440 | $159,639 | 21 | Sony Pictures Releasing | false | false |
| 30 | 29 | A Prophet | $82 | -72% | 1 | -1 | $82 | $160,982 | 15 | Sony Pictures Releasing | false | false |
