| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | The American | $16,662,333 | - | 2,823 | - | $5,902 | $19,806,118 | 1 | Focus Features | true | false |
| 2 | - | Machete | $14,102,888 | - | 2,670 | - | $5,281 | $14,102,888 | 1 | Twentieth Century Fox | true | false |
| 3 | - | Takers | $13,535,992 | - | 2,206 | - | $6,135 | $39,986,817 | 1 | Screen Gems | true | false |
| 4 | - | The Last Exorcism | $8,750,191 | - | 2,874 | - | $3,044 | $33,522,575 | 1 | Lionsgate | true | false |
| 5 | - | Going the Distance | $8,508,290 | - | 3,030 | - | $2,808 | $8,508,290 | 1 | Warner Bros. | true | false |
| 6 | - | The Expendables | $8,317,824 | - | 3,398 | - | $2,447 | $93,885,594 | - | Lionsgate | - | false |
| 7 | - | The Other Guys | $6,664,628 | - | 2,607 | - | $2,556 | $108,130,839 | - | Sony Pictures Entertainment (SPE) | - | false |
| 8 | - | Eat Pray Love | $6,175,610 | - | 2,663 | - | $2,319 | $70,279,644 | - | Sony Pictures Entertainment (SPE) | - | false |
| 9 | - | Inception | $5,884,355 | - | 1,704 | - | $3,453 | $278,457,609 | - | Warner Bros. | - | false |
| 10 | - | Nanny McPhee Returns | $4,806,685 | - | 2,708 | - | $1,774 | $23,672,660 | - | Universal Pictures | - | false |
| 11 | - | Despicable Me | $4,047,680 | - | 1,600 | - | $2,529 | $241,498,630 | - | Universal Pictures | - | false |
| 12 | - | Vampires Suck | $3,941,945 | - | 2,434 | - | $1,619 | $33,240,602 | - | Twentieth Century Fox | - | false |
| 13 | - | The Switch | $3,917,061 | - | 1,885 | - | $2,078 | $22,292,201 | - | Miramax | - | false |
| 14 | - | Piranha 3D | $3,010,152 | - | 1,789 | - | $1,682 | $23,105,959 | - | - | - | false |
| 15 | - | Avatar 2010 Special Edition | $2,961,801 | - | 812 | - | $3,647 | $8,481,701 | 1 | Twentieth Century Fox | true | false |
| 16 | - | Toy Story 3 | $2,735,035 | - | 1,520 | - | $1,799 | $408,890,408 | - | Walt Disney Studios Motion Pictures | - | false |
| 17 | - | Lottery Ticket | $2,717,275 | - | 1,310 | - | $2,074 | $21,074,972 | - | Warner Bros. | - | false |
| 18 | - | Scott Pilgrim vs. the World | $1,985,220 | - | 807 | - | $2,460 | $29,267,130 | - | Universal Pictures | - | false |
| 19 | - | Salt | $1,600,665 | - | 705 | - | $2,270 | $115,561,662 | - | Sony Pictures Entertainment (SPE) | - | false |
| 20 | - | Get Low | $1,561,454 | - | 560 | - | $2,788 | $5,760,386 | - | Sony Pictures Classics | - | false |
| 21 | - | Dinner for Schmucks | $1,275,303 | - | 804 | - | $1,586 | $71,166,816 | - | DreamWorks | - | false |
| 22 | - | Step Up 3D | $995,485 | - | 434 | - | $2,293 | $41,284,397 | - | Walt Disney Studios Motion Pictures | - | false |
| 23 | - | Grown Ups | $747,050 | - | 383 | - | $1,950 | $160,191,860 | - | Sony Pictures Entertainment (SPE) | - | false |
| 24 | - | Cats & Dogs: The Revenge of Kitty Galore | $643,127 | - | 455 | - | $1,413 | $42,209,323 | - | Warner Bros. | - | false |
| 25 | - | The Sorcerer's Apprentice | $600,448 | - | 357 | - | $1,681 | $61,776,459 | - | Walt Disney Studios Motion Pictures | - | false |
| 26 | - | The Twilight Saga: Eclipse | $545,245 | - | 396 | - | $1,376 | $298,798,466 | - | Summit Entertainment | - | false |
| 27 | - | The Kids Are All Right | $494,036 | - | 239 | - | $2,067 | $19,891,258 | - | Focus Features | - | false |
| 28 | - | Mao's Last Dancer | $444,200 | - | 95 | - | $4,675 | $1,782,210 | - | The Samuel Goldwyn Company | - | false |
| 29 | - | The Last Airbender | $420,220 | - | 248 | - | $1,694 | $131,157,151 | - | Paramount Pictures | - | false |
| 30 | - | Hubble 3D | $387,366 | - | 123 | - | $3,149 | $15,110,422 | - | Warner Bros. | - | false |
| 31 | - | Ramona and Beezus | $366,799 | - | 305 | - | $1,202 | $25,306,200 | - | Twentieth Century Fox | - | false |
| 32 | - | We Are Family | $366,354 | - | 78 | - | $4,696 | $366,354 | 1 | UTV Motion Pictures | true | false |
| 33 | - | The Karate Kid | $316,839 | - | 227 | - | $1,395 | $176,308,872 | - | Sony Pictures Entertainment (SPE) | - | false |
| 34 | - | The Girl Who Played with Fire | $301,856 | - | 157 | - | $1,922 | $6,643,255 | - | Music Box Films | - | false |
| 35 | - | Shrek Forever After | $248,302 | - | 145 | - | $1,712 | $238,371,987 | - | DreamWorks | - | false |
| 36 | - | Cairo Time | $222,075 | - | 55 | - | $4,037 | $905,576 | - | IFC Films | - | false |
| 37 | - | Charlie St. Cloud | $189,220 | - | 220 | - | $860 | $31,001,010 | - | Universal Pictures | - | false |
| 38 | - | The Tillman Story | $179,480 | - | 24 | - | $7,478 | $303,560 | - | The Weinstein Company | - | false |
| 39 | - | Knight and Day 2010 Re-release | $164,150 | - | 142 | - | $1,155 | $76,231,739 | - | Twentieth Century Fox | - | false |
| 40 | - | Animal Kingdom | $149,868 | - | 56 | - | $2,676 | $574,789 | - | Sony Pictures Classics | - | false |
| 41 | - | Winter's Bone | $148,801 | - | 90 | - | $1,653 | $5,640,006 | - | Roadside Attractions | - | false |
| 42 | - | What If... | $146,272 | - | 71 | - | $2,060 | $328,956 | - | Five & Two Pictures | - | false |
| 43 | - | Mesrine: Killer Instinct 2010 Re-release | $120,299 | - | 34 | - | $3,538 | $336,376 | 1 | Music Box Films | true | false |
| 44 | - | Predators | $113,825 | - | 111 | - | $1,025 | $51,788,833 | - | Twentieth Century Fox | - | false |
| 45 | - | Mesrine: Public Enemy No. 1 2010 Re-release | $100,242 | - | 31 | - | $3,233 | $100,242 | 1 | Music Box Films | true | false |
| 46 | - | I Am Love | $86,772 | - | 49 | - | $1,770 | $4,696,290 | - | Magnolia Pictures | - | false |
| 47 | - | Under the Sea 3D | $84,253 | - | 16 | - | $5,265 | $24,110,954 | - | Warner Bros. | - | false |
| 48 | - | Prince of Persia: The Sands of Time | $70,422 | - | 93 | - | $757 | $90,702,019 | - | Walt Disney Studios Motion Pictures | - | false |
| 49 | - | Flipped | $69,995 | - | 28 | - | $2,499 | $770,136 | - | Warner Bros. | - | false |
| 50 | - | The A-Team | $66,915 | - | 54 | - | $1,239 | $77,187,334 | - | Twentieth Century Fox | - | false |
| 51 | - | The Concert | $59,170 | - | 20 | - | $2,958 | $453,417 | - | The Weinstein Company | - | false |
| 52 | - | Soul Kitchen | $53,761 | - | 15 | - | $3,584 | $121,709 | - | IFC Films | - | false |
| 53 | - | The Wildest Dream | $48,697 | - | 18 | - | $2,705 | $424,239 | - | National Geographic Entertainment | - | false |
| 54 | - | Marmaduke | $47,065 | - | 45 | - | $1,045 | $33,630,347 | - | Twentieth Century Fox | - | false |
| 55 | - | Lebanon | $40,619 | - | 17 | - | $2,389 | $201,420 | - | Sony Pictures Classics | - | false |
| 56 | - | Restrepo | $37,243 | - | 33 | - | $1,128 | $1,180,303 | - | National Geographic Entertainment | - | false |
| 57 | - | Centurion | $37,174 | - | 19 | - | $1,956 | $99,204 | 1 | Magnolia Pictures | true | false |
| 58 | - | Peepli [Live] | $36,403 | - | 26 | - | $1,400 | $754,837 | - | UTV Motion Pictures | - | false |
| 59 | - | A Woman, a Gun and a Noodle Shop | $35,033 | - | 5 | - | $7,006 | $35,033 | 1 | Sony Pictures Classics | true | false |
| 60 | - | The Extra Man | $30,001 | - | 28 | - | $1,071 | $375,758 | - | Magnolia Pictures | - | false |
| 61 | - | Last Train Home | $24,207 | - | 1 | - | $24,207 | $24,207 | 1 | Zeitgeist Films | true | false |
| 62 | - | The Girl with the Dragon Tattoo | $22,563 | - | 23 | - | $981 | $10,019,207 | - | Music Box Films | - | false |
| 63 | - | Coco Chanel & Igor Stravinsky | $19,972 | - | 24 | - | $832 | $1,519,306 | - | Sony Pictures Classics | - | false |
| 64 | - | Magnificent Desolation: Walking on the Moon 3D | $18,476 | - | 1 | - | $18,476 | $34,004,523 | - | IMAX | - | false |
| 65 | - | A Film Unfinished | $18,164 | - | 5 | - | $3,632 | $123,641 | - | Oscilloscope | - | false |
| 66 | - | Cyrus | $17,524 | - | 26 | - | $674 | $7,381,108 | - | Fox Searchlight Pictures | - | false |
| 67 | - | Agora | $16,063 | - | 6 | - | $2,677 | $577,823 | - | Newmarket Films | - | false |
| 68 | - | Micmacs | $15,703 | - | 22 | - | $713 | $1,209,645 | - | Sony Pictures Classics | - | false |
| 69 | - | Deep Sea | $15,323 | - | 2 | - | $7,661 | $43,664,511 | - | Warner Bros. | - | false |
| 70 | - | My Dog Tulip | $14,718 | - | 1 | - | $14,718 | $19,590 | 1 | New Yorker Films | true | false |
| 71 | - | Exit Through the Gift Shop | $14,540 | - | 5 | - | $2,908 | $3,218,649 | - | - | - | false |
| 72 | - | Jean-Michel Basquiat: The Radiant Child | $13,452 | - | 7 | - | $1,921 | $194,806 | - | Arthouse Films | - | false |
| 73 | - | Solitary Man | $12,990 | - | 24 | - | $541 | $4,340,136 | - | Anchor Bay Films | - | false |
| 74 | - | Change of Plans | $12,027 | - | 2 | - | $6,013 | $36,086 | 1 | IFC Films | true | false |
| 75 | - | The Disappearance of Alice Creed | $11,540 | - | 6 | - | $1,923 | $147,072 | - | Anchor Bay Films | - | false |
| 76 | - | La soga | $11,140 | - | 5 | - | $2,228 | $161,832 | - | 7-57 Releasing | - | false |
| 77 | - | Joan Rivers: A Piece of Work | $10,161 | - | 16 | - | $635 | $2,921,181 | - | IFC Films | - | false |
| 78 | - | The Secret in Their Eyes | $9,615 | - | 17 | - | $565 | $6,348,641 | - | Sony Pictures Classics | - | false |
| 79 | - | Life During Wartime | $7,802 | - | 8 | - | $975 | $257,538 | - | IFC Films | - | false |
| 80 | - | The Cremaster Cycle 2010 Re-release | $7,373 | - | 1 | - | $7,373 | $104,931 | - | International Film Circuit | - | false |
| 81 | - | Date Night | $7,159 | - | 11 | - | $650 | $98,711,404 | - | Twentieth Century Fox | - | false |
| 82 | - | Ondine | $7,104 | - | 3 | - | $2,368 | $541,170 | - | Magnolia Pictures | - | false |
| 83 | - | White Wedding 2010 Re-release | $7,004 | - | 4 | - | $1,751 | $7,004 | 1 | Dada Films | true | false |
| 84 | - | Wild Grass | $6,287 | - | 9 | - | $698 | $362,886 | - | Sony Pictures Classics | - | false |
| 85 | - | Winnebago Man | $5,606 | - | 7 | - | $800 | $139,753 | - | Kino International | - | false |
| 86 | - | The People I've Slept With | $5,172 | - | 2 | - | $2,586 | $17,611 | - | - | - | false |
| 87 | - | Army of Crime | $4,518 | - | 2 | - | $2,259 | $25,535 | - | Lorber Films | - | false |
| 88 | - | Metropolis 2010 Re-release | $4,301 | - | 3 | - | $1,433 | $365,538 | - | Kino International | - | false |
| 89 | - | Dogtooth | $3,633 | - | 2 | - | $1,816 | $51,429 | - | Kino International | - | false |
| 90 | - | Princess Kaiulani | $3,395 | - | 3 | - | $1,131 | $876,304 | - | Roadside Attractions | - | false |
| 91 | - | Mademoiselle Chambon | $3,320 | - | 5 | - | $664 | $314,336 | - | Lorber Films | - | false |
| 92 | - | Spoken Word | $3,022 | - | 2 | - | $1,511 | $27,098 | - | Variance Films | - | false |
| 93 | - | The Milk of Sorrow | $3,022 | - | 2 | - | $1,511 | $6,416 | 1 | Olive Films | true | false |
| 94 | - | Please Give | $2,887 | - | 13 | - | $222 | $4,021,688 | - | Sony Pictures Classics | - | false |
| 95 | - | The Nature of Existence | $2,863 | - | 2 | - | $1,431 | $47,311 | - | Walking Shadows | - | false |
| 96 | - | Ran 2010 Re-release | $2,816 | - | 1 | - | $2,816 | $113,948 | - | Rialto Pictures | - | false |
| 97 | - | Mid-August Lunch | $2,414 | - | 1 | - | $2,414 | $673,721 | - | Zeitgeist Films | - | false |
| 98 | - | Two in the Wave | $1,644 | - | 1 | - | $1,644 | $28,179 | - | Lorber Films | - | false |
| 99 | - | Sea Monsters: A Prehistoric Adventure | $1,574 | - | 1 | - | $1,574 | $23,294,160 | - | National Geographic Entertainment | - | false |
| 100 | - | Countdown to Zero | $1,444 | - | 5 | - | $288 | $253,823 | - | Magnolia Pictures | - | false |
| 101 | - | Mother and Child | $1,214 | - | 2 | - | $607 | $1,100,501 | - | Sony Pictures Classics | - | false |
| 102 | - | Le combat dans l'île | $1,113 | - | 1 | - | $1,113 | $48,575 | - | The Film Desk | - | false |
| 103 | - | John Rabe | $1,109 | - | 1 | - | $1,109 | $56,716 | - | Strand Releasing | - | false |
| 104 | - | The Sicilian Girl 2010 Re-release | $1,057 | - | 2 | - | $528 | $23,942 | - | Music Box Films | - | false |
| 105 | - | Mississippi Mermaid | $1,005 | - | 1 | - | $1,005 | $23,842 | - | The Film Desk | - | false |
| 106 | - | Circle | $977 | - | 1 | - | $977 | $6,517 | 1 | Indican Pictures | true | false |
| 107 | - | Space Station 3D | $544 | - | 1 | - | $544 | $81,971,042 | - | IMAX | - | false |
| 108 | - | Rosencrantz and Guildenstern Are Undead | $450 | - | 1 | - | $450 | $67,765 | - | Indican Pictures | - | false |
| 109 | - | Everyone Else | $415 | - | 1 | - | $415 | $93,702 | - | The Cinema Guild | - | false |
| 110 | - | Promised Lands | $196 | - | 1 | - | $196 | $3,983 | - | The Film Desk | - | false |
| 111 | - | Neshoba | $88 | - | 1 | - | $88 | $12,510 | - | First Run | - | false |
