| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 1 | - | Astral City: A Spiritual Journey | $2,590,384 | - | 437 | - | $5,927 | $9,184,721 | 2 | 20th Century Fox International | false | false |
| 2 | 1 | The Karate Kid | $1,174,408 | -28.3% | 375 | - | $3,131 | $7,633,268 | 3 | Sony Pictures Releasing | false | false |
| 3 | - | Cats & Dogs: The Revenge of Kitty Galore | $720,776 | - | 189 | - | $3,813 | $2,861,548 | 2 | Warner Bros. | false | false |
| 4 | - | Going the Distance | $567,955 | - | 119 | - | $4,772 | $567,955 | 1 | Warner Bros. | true | false |
| 5 | - | The Last Airbender | $518,522 | - | 198 | - | $2,618 | $8,328,888 | 4 | Paramount Pictures International | false | false |
| 6 | - | Despicable Me | $411,497 | - | 290 | - | $1,418 | $12,237,715 | 6 | Universal Pictures International (UPI) | false | false |
| 7 | - | Inception | $401,233 | - | 208 | - | $1,929 | $9,270,731 | 6 | Warner Bros. | false | false |
| 8 | - | Killers | $313,710 | - | 116 | - | $2,704 | $2,005,842 | 3 | N/A | false | false |
| 9 | - | Solomon Kane | $252,636 | - | 69 | - | $3,661 | $252,636 | 1 | Paris Filmes | true | false |
| 10 | - | Hot Tub Time Machine | $246,463 | - | 62 | - | $3,975 | $246,463 | 1 | N/A | true | false |
| 11 | - | The Expendables | $222,969 | - | 142 | - | $1,570 | $5,093,477 | 5 | N/A | false | false |
| 12 | 2 | The Sorcerer's Apprentice | $155,068 | -37.6% | 147 | -32 | $1,054 | $4,550,812 | 5 | Walt Disney Pictures | false | false |
| 13 | 3 | 5 x Favela, Now by Ourselves | $95,531 | -20.1% | 34 | -5 | $2,809 | $564,683 | 3 | Sony Pictures Releasing | false | false |
| 14 | 4 | The Well Beloved One | $44,491 | -30.7% | 90 | +2 | $494 | $4,625,534 | 8 | Walt Disney Pictures | false | false |
| 15 | - | [Rec]² | $38,652 | - | 37 | - | $1,044 | $292,306 | 2 | PlayArte Pictures | false | false |
| 16 | - | Battle for Terra | $28,775 | - | 62 | - | $464 | $28,775 | 1 | PlayArte Pictures | true | false |
| 17 | 5 | Salt | $23,099 | -54.7% | 57 | -40 | $405 | $7,346,371 | 7 | Sony Pictures Releasing | false | false |
| 18 | - | Then She Found Me | $19,476 | - | 8 | - | $2,434 | $168,419 | 6 | Europa Filmes | false | false |
| 19 | - | Coco Chanel & Igor Stravinsky | $19,143 | - | 15 | - | $1,276 | $228,930 | 4 | N/A | false | false |
| 20 | - | The Merry Widow | $16,324 | - | 9 | - | $1,813 | $64,180 | 2 | Pandora Filmes | false | false |
| 21 | - | Shrek Forever After | $16,183 | - | 48 | - | $337 | $40,037,374 | 10 | Paramount Pictures International | false | false |
| 22 | - | Little Nicholas | $15,045 | - | 10 | - | $1,504 | $685,281 | 11 | N/A | false | false |
| 23 | - | 400 Against 1: A History of Organized Crime | $13,334 | - | 46 | - | $289 | $579,655 | 6 | PlayArte Pictures | false | false |
| 24 | 6 | Toy Story 3 | $7,247 | -23.5% | 35 | -7 | $207 | $24,125,206 | 13 | Walt Disney Pictures | false | false |
| 25 | 7 | A Prophet | $1,533 | -55.3% | 6 | - | $255 | $159,768 | 13 | Sony Pictures Releasing | false | false |
| 26 | 11 | Prince of Persia: The Sands of Time | $1,340 | +176.9% | 1 | -1 | $1,340 | $10,124,446 | 15 | Walt Disney Pictures | false | false |
| 27 | 8 | Dear John | $718 | -42% | 2 | -2 | $359 | $258,261 | 19 | Sony Pictures Releasing | false | false |
| 28 | 9 | The Back-up Plan | $678 | -41.2% | 1 | -3 | $678 | $3,373,151 | 14 | Sony Pictures Releasing | false | false |
| 29 | 13 | Chico Xavier | $646 | +421% | 7 | +6 | $92 | $17,229,064 | 24 | Sony Pictures Releasing | false | false |
| 30 | - | The Last Song | $342 | - | 3 | - | $114 | $102,140 | 14 | Walt Disney Pictures | false | false |
| 31 | 12 | The Two Deaths of Quincas Wateryell | $328 | +38.4% | 6 | +2 | $54 | $1,211,994 | 17 | Walt Disney Pictures | false | false |
| 32 | 10 | The Imaginarium of Doctor Parnassus | $34 | -93.6% | 1 | -1 | $34 | $157,575 | 19 | Sony Pictures Releasing | false | false |
| 33 | 14 | Alice in Wonderland | $22 | -51.1% | 1 | - | $22 | $27,445,461 | 21 | Walt Disney Pictures | false | false |
