| Rank | LW | Release
| Gross | %± LW | Theaters | Change | Average | Total Gross | Weeks | Distributor
| New This Week
| Estimated
|
|---|
| 8 | 16 | Avatar | $33,308 | +5,056% | 6 | +4 | $5,551 | $8,224,441 | 37 | 20th Century Fox International | false | false |
| 19 | 14 | Shrek Forever After | $994 | -40.8% | 2 | +1 | $497 | $4,023,017 | 15 | Paramount Pictures International | false | false |
| 18 | 12 | The Last Airbender | $1,035 | -78% | 10 | -16 | $103 | $1,749,534 | 8 | Paramount Pictures International | false | false |
| 16 | 15 | The Twilight Saga: Eclipse | $1,942 | +86% | 4 | -1 | $485 | $1,679,522 | 8 | N/A | false | false |
| 6 | 4 | Inception | $44,543 | -37.6% | 36 | -11 | $1,237 | $1,319,576 | 6 | Warner Bros. | false | false |
| 11 | 7 | Salt | $21,781 | -35.3% | 60 | -10 | $363 | $1,219,587 | 5 | Sony Pictures Releasing | false | false |
| 14 | 9 | The Sorcerer's Apprentice | $8,527 | -45.9% | 40 | -12 | $213 | $1,218,778 | 6 | Walt Disney Pictures | false | false |
| 15 | 11 | Despicable Me | $4,323 | -64.6% | 19 | -10 | $227 | $1,090,389 | 7 | Universal Pictures International (UPI) | false | false |
| 21 | - | Sex and the City 2 | $582 | - | 1 | - | $582 | $922,909 | 13 | Warner Bros. | false | false |
| 3 | 1 | The Expendables | $91,733 | -49.8% | 65 | - | $1,411 | $908,779 | 3 | N/A | false | false |
| 23 | 19 | Toy Story 3 | $68 | +54.5% | 1 | - | $68 | $665,744 | 10 | Walt Disney Pictures | false | false |
| 9 | 6 | Grown Ups | $31,174 | -42.9% | 44 | -4 | $708 | $649,268 | 4 | Sony Pictures Releasing | false | false |
| 24 | 18 | Knight and Day 2010 Re-release | $6 | -94.3% | 1 | -1 | $6 | $604,716 | 10 | 20th Century Fox International | false | false |
| 12 | 8 | Cats & Dogs: The Revenge of Kitty Galore | $11,837 | -29.7% | 28 | -24 | $422 | $490,617 | 5 | Warner Bros. | false | false |
| 17 | 13 | Predators | $1,071 | -43.4% | 3 | -5 | $357 | $395,837 | 8 | 20th Century Fox International | false | false |
| 7 | 2 | Step Up 3D | $41,291 | -56.7% | 33 | -3 | $1,251 | $388,939 | 3 | N/A | false | false |
| 5 | 3 | The Karate Kid | $51,562 | -37.4% | 47 | -1 | $1,097 | $242,156 | 2 | Sony Pictures Releasing | false | false |
| 1 | - | Piranha 3D | $215,738 | - | 49 | - | $4,402 | $215,738 | 1 | N/A | true | false |
| 4 | 5 | A Turtle's Tale: Sammy's Adventures | $58,183 | -13.9% | 40 | - | $1,454 | $184,573 | 2 | N/A | false | false |
| 20 | 17 | Get Him to the Greek | $679 | +177.1% | 2 | +1 | $339 | $161,368 | 11 | Universal Pictures International (UPI) | false | false |
| 22 | - | The Alien Girl | $201 | - | 1 | - | $201 | $117,410 | 9 | N/A | false | false |
| 2 | - | The Switch | $114,890 | - | 40 | - | $2,872 | $114,890 | 1 | N/A | true | false |
| 13 | 10 | Tinker Bell and the Great Fairy Rescue | $8,970 | -31.8% | 34 | -1 | $263 | $65,471 | 3 | Walt Disney Pictures | false | false |
| 10 | - | I Come with the Rain | $21,837 | - | 21 | - | $1,039 | $21,837 | 1 | - | true | false |
